Mucosal Immunology

Lung basement membranes are compositionally and structurally altered following resolution of influenza infection. Oliver Brand

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Mucosal Immunol. 2025 Nov 11:S1933-0219(25)00122-9. doi: 10.1016/j.mucimm.2025.11.005. Online ahead of print. ABSTRACT Identification of pathways preventing timely recovery from acute respiratory viral infection is under-studied but essential for long-term health. Using unbiased proteomics, we reveal an unexpected, reduction in lung basement membrane proteins 21 days after influenza infection when mice had symptomatically recovered. Basement membrane … Read more

Pantothenic acid alleviates endometrial injury induced by vagotomy in mice. Chongshan Yuan

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Mucosal Immunol. 2025 Nov 10:S1933-0219(25)00120-5. doi: 10.1016/j.mucimm.2025.11.003. Online ahead of print. ABSTRACT Endometrial injury triggers inflammation responses, and persistent inflammation is a recognized cause of infertility. Emerging evidence underscores the critical role of the vagus nerve in modulating immunity. Although vagotomy is known to induce systemic inflammation, the specific mechanism by which the vagus nerve … Read more

Placental intervillous blood harbors NK cells with distinct tissue-resident characteristics. Sara Vikberg

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Mucosal Immunol. 2025 Nov 4:S1933-0219(25)00117-5. doi: 10.1016/j.mucimm.2025.11.001. Online ahead of print. ABSTRACT The placental intervillous space is a unique immunological niche where circulating maternal immune cells come into direct contact with the fetal syncytiotrophoblast. While adaptations in immune cell composition are known to occur in the maternal decidua throughout pregnancy, it remains unclear whether similar … Read more

Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages. Andrew W Simonson

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Mucosal Immunol. 2025 Nov 2:S1933-0219(25)00115-1. doi: 10.1016/j.mucimm.2025.10.010. Online ahead of print. ABSTRACT Immunological memory elicited either through previous or ongoing M. tuberculosis (Mtb) infection provides a critical mechanism by which hosts protect against re-infection and disease progression upon Mtb re-exposure. Conversely, the uneven competition between distinct Mtb strains suggest certain bacterial clades have enhanced ability … Read more

IFN-γ- GranzymeB + Natural killer cells are induced by IV BCG vaccination and associated with protection against tuberculosis in rhesus macaques. Mohau S Makatsa

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Mucosal Immunol. 2025 Nov 1:S1933-0219(25)00116-3. doi: 10.1016/j.mucimm.2025.10.011. Online ahead of print. ABSTRACT Intravenous (IV) vaccination with Bacillus Calmette-Guerin (BCG) mediates sterilizing immunity against Mycobacterium tuberculosis (Mtb) in rhesus macaques but the cellular mechanisms underlying protection are undefined. We used mass cytometry (CyTOF) to broadly profile pulmonary immunity induced by IV BCG and observed an expansion … Read more

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity. Nabina Pun

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Mucosal Immunol. 2025 Oct 24:S1933-0219(25)00113-8. doi: 10.1016/j.mucimm.2025.10.008. Online ahead of print. ABSTRACT Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is known to help regulate tissue damage, immune mechanisms involved in RT-induced … Read more

Acsbg1 maintains intestinal immune homeostasis and controls inflammation by regulating ST2+ Tregs. Martina Palatella

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Mucosal Immunol. 2025 Oct 26:S1933-0219(25)00114-X. doi: 10.1016/j.mucimm.2025.10.009. Online ahead of print. ABSTRACT The immune balance in mucosal tissues depends on a delicate interplay between inflammatory T helper 17 (Th17) cells and immunosuppressive regulatory T cells (Tregs). But what happens when this balance is disturbed? In this study, we uncovered a critical role for acyl-CoA synthetase … Read more

Cytochrome P450 Cyp2s1 regulation of the intestinal metabolome and microbiome. Sara Dylgjeri

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Mucosal Immunol. 2025 Oct 19:S1933-0219(25)00112-6. doi: 10.1016/j.mucimm.2025.10.007. Online ahead of print. ABSTRACT Xenobiotics and environmental factors implicated in inflammatory bowel disease (IBD) are metabolized by cytochrome P450 enzymes. Cyp2s1, an orphan member of this family, is highly expressed in the intestine, yet its role remains unclear. Here, we investigated the function of Cyp2s1 in intestinal … Read more

T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease. Faith I Uwadiae

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Mucosal Immunol. 2025 Oct 15:S1933-0219(25)00107-2. doi: 10.1016/j.mucimm.2025.10.005. Online ahead of print. ABSTRACT T follicular helper cells (TFH) play a central role in orchestrating antibody mediated immunity. Despite the importance of antibody responses, especially allergen-specific IgE, in allergic airway diseases (AAD) such as asthma, the precise role TFH play in AADs has remained elusive. Using a … Read more

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