Mucosal Immunology

Mucosal Immunol. 2026 Jun 25:100369. doi: 10.1016/j.mucimm.2026.100369. Online ahead of print. ABSTRACT CD4+ T helper (Th) cell responses to commensal microbiota are linked to Inflammatory Bowel Disease (IBD), yet how Th programs coexist and evolve in human tissues remains poorly defined. Here, we profiled CD4+ memory T cells in intestinal biopsies using immunological and histological … Read more

Mucosal Immunol. 2026 Jun 25:100370. doi: 10.1016/j.mucimm.2026.100370. Online ahead of print. ABSTRACT GPR15 is a colon homing receptor, but its pattern of expression among gut intestinal intraepithelial lymphocytes and its role on intestinal intraepithelial lymphocyte and epithelial homeostasis, as well as systemic metabolism and hormones remain unknown. GPR15L is the only ligand for GPR15 described … Read more

Mucosal Immunol. 2026 Jun 25:100368. doi: 10.1016/j.mucimm.2026.100368. Online ahead of print. ABSTRACT Dysregulation of regulatory T cells (Tregs) is a hallmark of immune imbalance in ulcerative colitis (UC), in which their suppressive function relies heavily on post-translational modifications and the stabilization of the transcription factor Foxp3. However, the upstream regulatory mechanisms remain poorly understood. Here, … Read more

Mucosal Immunol. 2026 Jun 24:100366. doi: 10.1016/j.mucimm.2026.100366. Online ahead of print. ABSTRACT Pregnancy comes with complex immune adaptations to support the specific needs of each pregnancy stage. Infections during pregnancy pose an additional challenge in keeping the fine balance between protective and detrimental immune activation. Whether mucosal immunity adapts to different pregnancy stages is poorly … Read more

Mucosal Immunol. 2026 Jun 24:100367. doi: 10.1016/j.mucimm.2026.100367. Online ahead of print. ABSTRACT Hookworms migrate through the lung as part of their lifecycle, causing significant tissue damage that activates tissue-resident populations such as ILC2s. These drive type 2 immune responses critical for wound healing and the development of protective immunity. Monocyte-derived macrophages that seed the lung … Read more

Mucosal Immunol. 2026 Jun 22:100365. doi: 10.1016/j.mucimm.2026.100365. Online ahead of print. ABSTRACT Adaptive immune responses, including B and T cell responses, play important roles in establishing and maintaining the mutualistic relationship between the host and intestinal microbiota. Host-microbiota mutualism is disrupted in various immune-mediated inflammatory diseases, including Crohn’s disease (CD). Aberrant inflammatory memory CD4+ T … Read more

Mucosal Immunol. 2026 Jun 21:100364. doi: 10.1016/j.mucimm.2026.100364. Online ahead of print. ABSTRACT The development and progression of respiratory diseases are influenced by both the local pulmonary microenvironment and the intestinal ecosystem. Research on the gut-lung axis has shown that diverse small-molecule metabolites produced or modified by the gut microbiota can cross the intestinal barrier and … Read more

Mucosal Immunol. 2026 Jun 17:100363. doi: 10.1016/j.mucimm.2026.100363. Online ahead of print. ABSTRACT Barrier tissues are sites of constant environmental exposure and require tightly coordinated mechanisms to maintain immune homeostasis while preserving tissue integrity. Emerging evidence supports the concept of a neuro-epithelial unit, in which neurons and epithelial cells function as integrated regulatory modules. In this … Read more

Mucosal Immunol. 2026 Jun 11:100362. doi: 10.1016/j.mucimm.2026.100362. Online ahead of print. ABSTRACT BACKGROUND: Durable protection against viral infections relies on tissue-resident memory T (TRM) cells at pathogen entry sites. The oral cavity is a critical mucosal barrier frequently exposed to viral pathogens; however, the phenotypic characteristics and spatial organization of virus-specific T cells in the … Read more

Mucosal Immunol. 2026 Jun 11:100361. doi: 10.1016/j.mucimm.2026.100361. Online ahead of print. ABSTRACT Ulcerative colitis (UC) is characterized by chronic mucosal inflammation, recurrent epithelial injury, and impaired colonic mucosal wound healing. While WNT/β-catenin dysregulation has been reported in UC, the mechanisms of such abnormalities remain unclear. To investigate epithelial intrinsic alterations associated with UC, we performed … Read more