Mucosal Immunology

Specialized pro-resolving mediators regulate in vitro human airway epithelial resistance to Aspergillus fumigatus. Khadeeja Adam Sy

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Mucosal Immunol. 2026 Jul 7:100379. doi: 10.1016/j.mucimm.2026.100379. Online ahead of print. ABSTRACT Cystic fibrosis (CF) is caused by mutations in the CFTR gene resulting in alterations in the immune functions of the airway epithelium, including reduced biosynthesis of the specialized pro-resolving lipid mediators (SPMs). Aspergillus fumigatus is the most isolated filamentous fungus in patients with … Read more

Beyond pathogen recognition: C-type lectin receptors in microbiota regulation. Morgan Greenewood

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Mucosal Immunol. 2026 Jul 5:100376. doi: 10.1016/j.mucimm.2026.100376. Online ahead of print. ABSTRACT A central challenge faced by the immune system is not simply detecting microbes but determining how to respond to them. In the intestine, where commensals and pathogens coexist, this decision is neither binary nor dictated by a single receptor. Instead, it emerges from … Read more

Mucin degradation by Akkermansia muciniphila promotes Alistipes-dependent tryptophan metabolism and Th17-driven autoimmunity. Xun Lin

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Mucosal Immunol. 2026 Jul 4:100377. doi: 10.1016/j.mucimm.2026.100377. Online ahead of print. ABSTRACT Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system associated with alterations in gut commensals, including Akkermansia muciniphila (A. muciniphila). However, its role in MS remains unclear. Here, we report elevated serum lipopolysaccharide (LPS) and anti-LPS IgG levels in patients … Read more

Bioinformatics roadmap for characterizing the gut microbiome to study its interactions and associations with the gut mucosal immune system. Muhammad Zohaib Anwar

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Mucosal Immunol. 2026 Jul 2:100375. doi: 10.1016/j.mucimm.2026.100375. Online ahead of print. ABSTRACT Cataloging the gut microbiome and understanding its interactions and association with the host immune system remains relevant to identify potential treatments for complex chronic diseases, including cancer. Studying the gut microbiome is more accessible than ever, thanks to the dramatic cost reduction of … Read more

Helminths hijack the TGFβ receptor to promote a pro-regenerative program in the intestinal stem cell compartment. Danielle Karo-Atar

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Mucosal Immunol. 2026 Jul 2:100372. doi: 10.1016/j.mucimm.2026.100372. Online ahead of print. ABSTRACT The intestine is a multifunctional tissue relying on multipotent stem cells to establish a repertoire of epithelial cell lineages. We have previously shown that the enteric parasitic nematode Heligmosomoides polygyrus bakeri (Hpb) directly regulates the intestinal stem cell compartment, tuning the epithelium to … Read more

4-1BBL on monocyte lineage cells rather than on classical dendritic cells drives CD8+ T cell accumulation in the respiratory tract and protects from severe respiratory influenza infection. Karen K M Yeung

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Mucosal Immunol. 2026 Jul 1:100374. doi: 10.1016/j.mucimm.2026.100374. Online ahead of print. ABSTRACT Seasonal epidemics and the persistent threat of a pandemic provide a strong impetus to understand mechanisms of protection against influenza infection. T cell intrinsic signaling through the TNFR superfamily member 4-1BB is critical for the accumulation of antigen-specific CD8+ effector and memory T … Read more

BAMBI: A novel regulator of intestinal epithelial integrity in the control of colitis and colon cancer progression. Marta Muñoz

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Mucosal Immunol. 2026 Jun 30:100373. doi: 10.1016/j.mucimm.2026.100373. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease affects approximately 7 million individuals worldwide. Its pathogenesis involves genetic susceptibility, alterations in the gut microbiota, and immune system imbalance, with both innate and adaptive components contributing through aberrant cytokine signaling. The … Read more

Postbiotic Lactobacillus sakei CVL-001 promotes mucosal tolerance via NOD2-dependent programming of tolerogenic CD11c+ antigen-presenting cells. Dong-Yeon Kim

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Mucosal Immunol. 2026 Jun 27:100371. doi: 10.1016/j.mucimm.2026.100371. Online ahead of print. ABSTRACT Postbiotics offer improved safety and stability over live probiotics for modulating intestinal immunity, yet the receptor-mediated mechanisms underlying mucosal tolerance remain unclear. Nucleotide-binding oligomerization domain 2 (NOD2), a cytosolic sensor of bacterial cell wall components and a major genetic risk factor for inflammatory … Read more

Tissue-embedded CD4+ plasticity defines mucosal immunity in inflammatory bowel disease. Qinyue Jiang

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Mucosal Immunol. 2026 Jun 25:100369. doi: 10.1016/j.mucimm.2026.100369. Online ahead of print. ABSTRACT CD4+ T helper (Th) cell responses to commensal microbiota are linked to Inflammatory Bowel Disease (IBD), yet how Th programs coexist and evolve in human tissues remains poorly defined. Here, we profiled CD4+ memory T cells in intestinal biopsies using immunological and histological … Read more

GPR15-GPR15L axis controls colon unconventional TCRαβ cells residency and enteroendocrine cell homeostasis to calibrate metabolism. Borja Ocón

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Mucosal Immunol. 2026 Jun 25:100370. doi: 10.1016/j.mucimm.2026.100370. Online ahead of print. ABSTRACT GPR15 is a colon homing receptor, but its pattern of expression among gut intestinal intraepithelial lymphocytes and its role on intestinal intraepithelial lymphocyte and epithelial homeostasis, as well as systemic metabolism and hormones remain unknown. GPR15L is the only ligand for GPR15 described … Read more

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