Mucosal Immunology

ADP-ribosylation factor 1 sustains regulatory T cell function and mucosal immune homeostasis in ulcerative colitis. Hua-Hua Liu

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Mucosal Immunol. 2026 Jun 25:100368. doi: 10.1016/j.mucimm.2026.100368. Online ahead of print. ABSTRACT Dysregulation of regulatory T cells (Tregs) is a hallmark of immune imbalance in ulcerative colitis (UC), in which their suppressive function relies heavily on post-translational modifications and the stabilization of the transcription factor Foxp3. However, the upstream regulatory mechanisms remain poorly understood. Here, … Read more

Pregnancy stages differentially impact maternal alveolar macrophages’ function and immunity to SARS-CoV-2 infection. Alina Fokina

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Mucosal Immunol. 2026 Jun 24:100366. doi: 10.1016/j.mucimm.2026.100366. Online ahead of print. ABSTRACT Pregnancy comes with complex immune adaptations to support the specific needs of each pregnancy stage. Infections during pregnancy pose an additional challenge in keeping the fine balance between protective and detrimental immune activation. Whether mucosal immunity adapts to different pregnancy stages is poorly … Read more

ILC2s govern imprinting of alveolar macrophage-mediated immune responses upon secondary helminth infection in the lung. Jonathan Pollock

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Mucosal Immunol. 2026 Jun 24:100367. doi: 10.1016/j.mucimm.2026.100367. Online ahead of print. ABSTRACT Hookworms migrate through the lung as part of their lifecycle, causing significant tissue damage that activates tissue-resident populations such as ILC2s. These drive type 2 immune responses critical for wound healing and the development of protective immunity. Monocyte-derived macrophages that seed the lung … Read more

Adaptive immune responses against Lachnospiraceae-derived flagellins and their role in inflammatory bowel disease. Daniëlle M H Barendregt

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Mucosal Immunol. 2026 Jun 22:100365. doi: 10.1016/j.mucimm.2026.100365. Online ahead of print. ABSTRACT Adaptive immune responses, including B and T cell responses, play important roles in establishing and maintaining the mutualistic relationship between the host and intestinal microbiota. Host-microbiota mutualism is disrupted in various immune-mediated inflammatory diseases, including Crohn’s disease (CD). Aberrant inflammatory memory CD4+ T … Read more

From the gut to the lung: microbiota-associated metabolites as regulators of respiratory immunometabolism. Jun-Yan Xiang

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Mucosal Immunol. 2026 Jun 21:100364. doi: 10.1016/j.mucimm.2026.100364. Online ahead of print. ABSTRACT The development and progression of respiratory diseases are influenced by both the local pulmonary microenvironment and the intestinal ecosystem. Research on the gut-lung axis has shown that diverse small-molecule metabolites produced or modified by the gut microbiota can cross the intestinal barrier and … Read more

A neuro-epithelial unit regulates immunohomeostasis at barrier surfaces. Manuel O Jakob

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Mucosal Immunol. 2026 Jun 17:100363. doi: 10.1016/j.mucimm.2026.100363. Online ahead of print. ABSTRACT Barrier tissues are sites of constant environmental exposure and require tightly coordinated mechanisms to maintain immune homeostasis while preserving tissue integrity. Emerging evidence supports the concept of a neuro-epithelial unit, in which neurons and epithelial cells function as integrated regulatory modules. In this … Read more

Virus-specific resident memory T cell networks sustain immunity in human oral mucosa. Florian Winkler

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Mucosal Immunol. 2026 Jun 11:100362. doi: 10.1016/j.mucimm.2026.100362. Online ahead of print. ABSTRACT BACKGROUND: Durable protection against viral infections relies on tissue-resident memory T (TRM) cells at pathogen entry sites. The oral cavity is a critical mucosal barrier frequently exposed to viral pathogens; however, the phenotypic characteristics and spatial organization of virus-specific T cells in the … Read more

RUNX2 promotes chromatin accessibility and WNT signaling in inflamed intestinal epithelial cells. Rodolfo I Cabrera-Silva

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Mucosal Immunol. 2026 Jun 11:100361. doi: 10.1016/j.mucimm.2026.100361. Online ahead of print. ABSTRACT Ulcerative colitis (UC) is characterized by chronic mucosal inflammation, recurrent epithelial injury, and impaired colonic mucosal wound healing. While WNT/β-catenin dysregulation has been reported in UC, the mechanisms of such abnormalities remain unclear. To investigate epithelial intrinsic alterations associated with UC, we performed … Read more

Tuft cells protect against intestinal inflammation through histone deacetylase 3. Emily M Eshleman

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Mucosal Immunol. 2026 Jun 3:100356. doi: 10.1016/j.mucimm.2026.100356. Online ahead of print. ABSTRACT While intestinal tuft cells are well known to promote type 2 immunity, their role in inflammatory bowel disease (IBD) remains unclear. Here, we show that tuft cells are reduced in the distal intestine of pediatric IBD patients and that tuft cell-deficient mice exhibited … Read more

Localization of TCR-expressing natural intraepithelial lymphocytes in the colon epithelium depends on GPR15 and epithelium-derived C10ORF99. Gerald J O’Connor

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Mucosal Immunol. 2026 Jun 1:100355. doi: 10.1016/j.mucimm.2026.100355. Online ahead of print. ABSTRACT Intraepithelial lymphocytes (IELs) are among the largest lymphocyte populations in the body and play a crucial role in maintaining the integrity of epithelial barriers at mucosal sites, which are highly immunostimulatory. Therefore, understanding how these cells are generated, localized within the epithelium, and … Read more

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