Mucosal Immunology

Mucosal Immunol. 2025 Apr 19:S1933-0219(25)00044-3. doi: 10.1016/j.mucimm.2025.04.006. Online ahead of print. ABSTRACT Protein arginine deiminase 4 (PAD4) has emerged as a potential therapeutic target for various diseases due to its role in promoting neutrophil extracellular trap (NET) formation. NETs, composed of DNA and antimicrobial proteins, serve as a defense mechanism against pathogens but can also … Read more

Mucosal Immunol. 2025 Apr 17:S1933-0219(25)00042-X. doi: 10.1016/j.mucimm.2025.04.004. Online ahead of print. ABSTRACT Promoting intestinal regeneration and enhancing mucosal healing have emerged as promising therapeutic alternatives for treating intestinal disorders that compromise epithelial barrier integrity and function. However, the cellular and molecular mechanisms underlying these processes remain poorly understood. This knowledge gap is partly due to … Read more

Mucosal Immunol. 2025 Apr 13:S1933-0219(25)00041-8. doi: 10.1016/j.mucimm.2025.04.003. Online ahead of print. ABSTRACT The colonic mucus layer acts as a physicochemical barrier to pathogen invasion and as a habitat for mucus-associated microbes. This mucosal microbiome plays a crucial role in moderating mucus production, maintaining barrier integrity, and shaping the host immune response. However, unchecked mucin foraging … Read more

Mucosal Immunol. 2025 Apr 11:S1933-0219(25)00040-6. doi: 10.1016/j.mucimm.2025.04.002. Online ahead of print. ABSTRACT Roux-en-Y gastric bypass (GBP) surgery is an effective treatment for reducing body weight and correcting metabolic dysfunction in individuals with severe obesity. Herein, we characterize the differences between very low energy diet (VLED) and GBP induced weight loss by multi-omic analyses of microbiome … Read more

Mucosal Immunol. 2025 Apr 10:S1933-0219(25)00039-X. doi: 10.1016/j.mucimm.2025.04.001. Online ahead of print. ABSTRACT Humans breathe thousands of litres of non-sterile air each day containing bacteria, viruses, and fungi, as well as pollutants, allergens, and other particles. The continual exposure to foreign particles is juxtaposed with the vast surface area of the blood-air-barrier which becomes extremely thin … Read more

Mucosal Immunol. 2025 Apr 1:S1933-0219(25)00032-7. doi: 10.1016/j.mucimm.2025.03.006. Online ahead of print. ABSTRACT Intranasal vaccines potentially offer superior protection against viral infections compared with injectable vaccines. The immunogenicity of intranasal vaccines including adenovirus vector (AdV), has room for improvement, while few options are available for safe execution. In this study, we demonstrate that modifying a basic … Read more

Mucosal Immunol. 2025 Mar 29:S1933-0219(25)00033-9. doi: 10.1016/j.mucimm.2025.03.007. Online ahead of print. ABSTRACT Alterations in goblet cell biology constitute one of the most effective host responses against enteric parasites. In the gastrointestinal (GI) tract, millions of bacteria influence these goblet cell responses by binding to pattern recognition receptors such as toll-like receptors (TLRs). Studies suggest that … Read more

Mucosal Immunol. 2025 Mar 28:S1933-0219(25)00030-3. doi: 10.1016/j.mucimm.2025.03.004. Online ahead of print. ABSTRACT Adult skin varies across regions, with differences in chemical, physical, microbiota, and immune barriers. However, data on topographical immune differences in other age groups are limited. This study aimed to explore the chronological maturation of the immune barrier in various skin regions. A … Read more

Mucosal Immunol. 2025 Mar 28:S1933-0219(25)00031-5. doi: 10.1016/j.mucimm.2025.03.005. Online ahead of print. ABSTRACT Heatstroke (HS) is typically considered a sepsis-like syndrome caused by hyperthermia, often accompanied by multiple organ dysfunctions (MODS). To explore the mechanisms of MODS, we established a mouse model of HS by exposing mice to a hyperthermic and high-humidity environment. Then, we utilized … Read more

Mucosal Immunol. 2025 Mar 26:S1933-0219(25)00029-7. doi: 10.1016/j.mucimm.2025.03.003. Online ahead of print. ABSTRACT Our understanding of the airway epithelium’s role in driving asthma pathogenesis has evolved over time. From being regarded primarily as a physical barrier that could be damaged via inflammation, the epithelium is now known to actively contribute to asthma development through interactions with … Read more