Mucosal Immunology – Page 6

Corrigendum to “Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection” [Mucosal. Immun. 17 (2024) 1242-1255]. Amanpreet Singh Chawla

8 de August de 2025 by inmunoadmin

Mucosal Immunol. 2025 Aug;18(4):1003. doi: 10.1016/j.mucimm.2025.06.003. Epub 2025 Aug 5. NO ABSTRACT PMID:40774771 | DOI:10.1016/j.mucimm.2025.06.003

Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells. Samuel Alvarez-Arguedas

29 de July de 2025 by inmunoadmin

Mucosal Immunol. 2025 Jul 26:S1933-0219(25)00077-7. doi: 10.1016/j.mucimm.2025.07.006. Online ahead of print. ABSTRACT The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While mucosal surfaces can function as both entry points and barriers to infection, mucosa-associated lymphoid tissues (MALT) facilitate early immune responses to … Read more

Dynamics of virus-specific CD8+ T cells in the human nasal cavity. Joey Ming Er Lim

25 de July de 2025 by inmunoadmin

Mucosal Immunol. 2025 Jul 22:S1933-0219(25)00078-9. doi: 10.1016/j.mucimm.2025.07.007. Online ahead of print. ABSTRACT The nasal cavity is the entry site for respiratory viruses. Understanding how the nasal cavity sustains memory CD8+ T cell is essential for improving respiratory virus management and vaccine development. Here, we sampled CD8+ T cells from the upper nasal turbinate and peripheral … Read more

Microbial dysbiosis sculpts a systemic ILC3/IL-17 axis governing lung inflammatory responses. Ahmed Kabil

23 de July de 2025 by inmunoadmin

Mucosal Immunol. 2025 Jul 20:S1933-0219(25)00073-X. doi: 10.1016/j.mucimm.2025.07.002. Online ahead of print. ABSTRACT Advancements in vaccination and sanitation have significantly reduced the prevalence and burden of infectious diseases; however, these benefits have coincided with a marked rise in autoimmune and allergic disorders. Recent studies have investigated these linked trends through the lens of host-microbiome alterations, proposing … Read more

M2 macrophage-derived Apolipoprotein E promotes fibroblast MMPs expression via LRP1-ERK signaling in chronic rhinosinusitis with nasal polyps. Ying Zhu

22 de July de 2025 by inmunoadmin

Mucosal Immunol. 2025 Jul 19:S1933-0219(25)00075-3. doi: 10.1016/j.mucimm.2025.07.004. Online ahead of print. ABSTRACT Apolipoprotein E (APOE) expressed by macrophages modulates allergic inflammation and remodeling of the lower airway. However, its expression and functions in chronic rhinosinusitis with nasal polyps (CRSwNP) remain unclear. We sought to investigate the involvement of macrophage derived APOE in the pathogenesis of … Read more

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling. Sara Alonso

20 de July de 2025 by inmunoadmin

Mucosal Immunol. 2025 Jul 17:S1933-0219(25)00076-5. doi: 10.1016/j.mucimm.2025.07.005. Online ahead of print. ABSTRACT Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferative γδ IEL (γδHYP) phenotype also upregulate the expression of the ectonucleotidase CD39, a marker of regulatory γδ T … Read more

TRIM33 prevents the exacerbation of allergic asthma by restricting the overactivation of alveolar macrophages. Jiaoyan Lv

19 de July de 2025 by inmunoadmin

Mucosal Immunol. 2025 Jul 16:S1933-0219(25)00074-1. doi: 10.1016/j.mucimm.2025.07.003. Online ahead of print. ABSTRACT Alveolar macrophages (AMs) and dendritic cells (DCs) are the two major types of primary innate immune cells in allergic asthma and their functions were elaborately regulated during the progression of asthma. Tripartite motif-containing protein 33 (TRIM33) is a multifunctional protein that regulates differentiation … Read more

Type-I interferons in Vulvovaginal Candidiasis: Mechanism of epithelial early defense and immune regulation against Candida albicans. Emilse Rodriguez

13 de July de 2025 by inmunoadmin

Mucosal Immunol. 2025 Jul 10:S1933-0219(25)00072-8. doi: 10.1016/j.mucimm.2025.07.001. Online ahead of print. ABSTRACT Vulvovaginal candidiasis (VVC) is a mucosal infection predominantly caused by Candida albicans, affecting over three-quarters of immunocompetent women worldwide. While the female genital tract mucosa is the primary defense against the fungus, the specific immune mechanisms involved in this host-pathogen interaction remain largely … Read more

Tofacitinib ameliorates Campylobacter-induced intestinal pathology by suppressing IFNγ producing ILCs and T cells. Anna A Korchagina

5 de July de 2025 by inmunoadmin

Mucosal Immunol. 2025 Jul 2:S1933-0219(25)00070-4. doi: 10.1016/j.mucimm.2025.06.010. Online ahead of print. ABSTRACT Patients with autoimmune diseases are more susceptible to foodborne infections, which can be exacerbated by immunosuppressive therapy. Tofacitinib, a JAK/STAT pathway inhibitor, was recently approved for the treatment of ulcerative colitis, yet its effects on the pathogenesis of intestinal infections remain unclear. Here, … Read more

Fibroblast-derived CSF1 maintains colonization of gut mucosal macrophage to resist bacterial infection. Daichi Nonaka

4 de July de 2025 by inmunoadmin

Mucosal Immunol. 2025 Jul 1:S1933-0219(25)00071-6. doi: 10.1016/j.mucimm.2025.06.011. Online ahead of print. ABSTRACT Macrophages play essential roles in immune defense and tissue homeostasis, but the mechanisms underlying their colonization in the gut mucosa remain incompletely understood. Here, we identify CSF1, primarily derived from fibroblasts, as the dominant factor maintaining mucosal macrophage colonization, whereas IL-34 deficiency alone … Read more

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