Mucosal Immunology

Antibiotic-Induced dysbiosis of the ocular microbiome affects corneal circadian rhythmic activity in mice. Xinwei Jiao

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Mucosal Immunol. 2025 Feb 5:S1933-0219(25)00010-8. doi: 10.1016/j.mucimm.2025.01.010. Online ahead of print. ABSTRACT The ocular surface microbiota plays a critical role in maintaining corneal homeostasis, but its disruption and subsequent effects on corneal functions remain poorly understood. This study investigates how antibiotic-induced microbial depletion affects the corneal circadian transcriptome in C57BL/6J mice. Dysbiosis was induced using … Read more

Mitochondrial damage-associated molecular patterns: New perspectives for mitochondria and inflammatory bowel diseases. Zhijie Wang

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Mucosal Immunol. 2025 Feb 5:S1933-0219(25)00013-3. doi: 10.1016/j.mucimm.2025.01.013. Online ahead of print. ABSTRACT Mitochondria are key regulators of inflammatory responses and mitochondrial dysfunction is closely linked to various inflammatory diseases. Increasing genetic and experimental evidence suggests that mitochondria play a critical role in inflammatory bowel disease (IBD). In the complex environment of the intestinal tract, intestinal … Read more

There’s no place like home: How local tissue microenvironments shape the function of innate lymphoid cells. Luke B Roberts

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Mucosal Immunol. 2025 Feb 1:S1933-0219(25)00012-1. doi: 10.1016/j.mucimm.2025.01.012. Online ahead of print. ABSTRACT Innate lymphoid cells (ILC) have emerged as critical immune effectors with key roles in orchestrating the wider immune response. While ILC are relatively rare cells they are found enriched within discrete microenvironments, predominantly within barrier tissues. An emerging body of evidence implicates complex … Read more

Tear duct M cells exacerbate allergic conjunctivitis by facilitating germinal-center reactions. Yuki Oya

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Mucosal Immunol. 2025 Feb 1:S1933-0219(25)00009-1. doi: 10.1016/j.mucimm.2025.01.009. Online ahead of print. ABSTRACT The ocular mucosal surface regularly encounters external materials in the air and tear fluids. Microfold (M) cells, specialized epithelial cells for antigen uptake, are present in tear duct-associated lymphoid tissue (TALT) within the nasolacrimal sac; however, their immunological significance is unclear. We generated … Read more

Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections. Clarissa Santos Rocha

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Mucosal Immunol. 2025 Jan 31:S1933-0219(25)00011-X. doi: 10.1016/j.mucimm.2025.01.011. Online ahead of print. ABSTRACT Gut inflammatory diseases cause microbial dysbiosis. Human immunodeficiency virus-1 (HIV) infection disrupts intestinal integrity, subverts repair/renewal pathways, impairs mucosal immunity and propels microbial dysbiosis. However, microbial metabolic mechanisms driving repair mechanisms in virally inflamed gut are not well understood. We investigated the capability … Read more

Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection. Jooyoung Kim

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Mucosal Immunol. 2025 Jan 28:S1933-0219(25)00008-X. doi: 10.1016/j.mucimm.2025.01.008. Online ahead of print. ABSTRACT Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the … Read more

Maternal obesity associates with altered humoral immunity in blood and colostrum. Erick S Sánchez-Salguero

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Mucosal Immunol. 2025 Jan 25:S1933-0219(25)00007-8. doi: 10.1016/j.mucimm.2025.01.007. Online ahead of print. ABSTRACT Maternal obesity is a condition with increasing prevalence worldwide, that correlates with negative infant outcomes. Here we performed an observational cross-sectional study, where peripheral blood and colostrum samples from 37 mothers with BMI between 18.5-25 or > 30 kg/m2 (21 and 16 mothers, … Read more

Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age. Julia A Brown

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Mucosal Immunol. 2025 Jan 23:S1933-0219(25)00006-6. doi: 10.1016/j.mucimm.2025.01.006. Online ahead of print. ABSTRACT Our immune system and gut microbiota are intricately coupled from birth, both going through maturation during early life and senescence during aging almost in a synchronized fashion. The symbiotic relationship between the human host and microbiota is critically dependent on a healthy immune … Read more

TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice. Lena Erkert

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Mucosal Immunol. 2025 Jan 20:S1933-0219(25)00003-0. doi: 10.1016/j.mucimm.2025.01.003. Online ahead of print. ABSTRACT Intestinal immune homeostasis relies on intestinal epithelial cells (IECs), which provide an efficient barrier, and warrant a state of tolerance between the microbiome and the mucosal immune system. Thus, proper epithelial microbial sensing and handling of microbes is key to preventing excessive immunity, … Read more

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