Mucosal Immunol. 2025 May 30:S1933-0219(25)00054-6. doi: 10.1016/j.mucimm.2025.05.007. Online ahead of print. ABSTRACT A principal reason for the high global morbidity and mortality of tuberculosis (TB) is the lack of efficacy of the only licensed TB vaccine, Bacillus Calmette-Guérin (BCG), as intradermal BCG does not induce local pulmonary immune memory. Animal studies have shown that inhalation … Read more

Mucosal Immunol. 2025 May 25:S1933-0219(25)00053-4. doi: 10.1016/j.mucimm.2025.05.006. Online ahead of print. ABSTRACT IL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucosal-Associated-Invariant-T-cells (MAIT), a subset of innate-like T cells with features of both Th1 and Th17 lineages, are increasingly recognized for their roles in mucosal immunity. … Read more

Mucosal Immunol. 2025 May 23:S1933-0219(25)00052-2. doi: 10.1016/j.mucimm.2025.05.005. Online ahead of print. ABSTRACT Inflammatory chemokine receptors CCR1/2/3/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here we utilise an influenza A virus (IAV) challenge to investigate the combinatorial roles of the iCCRs … Read more

Mucosal Immunol. 2025 May 19:S1933-0219(25)00050-9. doi: 10.1016/j.mucimm.2025.05.003. Online ahead of print. ABSTRACT The REG/Reg gene locus encodes a conserved family of potent antimicrobial but also pancreatitis-associated proteins. Here we investigated whether REG/Reg family members differ in their baseline expression levels and abilities to be regulated in the pancreas and gut upon perturbations. We found, in … Read more

Mucosal Immunol. 2025 May 16:S1933-0219(25)00051-0. doi: 10.1016/j.mucimm.2025.05.004. Online ahead of print. ABSTRACT Helminth infections affect billions of people worldwide and cause substantial morbidity. Intestinal helminth infection provokes Type 2 inflammation orchestrated by CD4+ T helper type 2 (Th2) cells. Th2 cells cooperate with group 2 innate lymphoid cells (ILC2s) to produce interleukin (IL)-4 and IL-13 … Read more

Mucosal Immunol. 2025 May 14:S1933-0219(25)00049-2. doi: 10.1016/j.mucimm.2025.05.002. Online ahead of print. ABSTRACT The parasite Cryptosporidium is a leading cause of diarrhea and death in malnourished children and immunocompromised individuals and an important enteric pathogen of livestock. A mucosal vaccine to mitigate clinical disease and decrease transmission would address the public health impact of this organism, … Read more

Mucosal Immunol. 2025 May 10:S1933-0219(25)00048-0. doi: 10.1016/j.mucimm.2025.05.001. Online ahead of print. ABSTRACT Staphylococcus aureus is a significant cause of pulmonary infections, but existing mouse models fail to recapitulate human-specific responses. In this study, we developed a novel mouse model of S. aureus infection using humanized mice implanted with autologous fetal lung tissue. We show that … Read more

Mucosal Immunol. 2025 May 3:S1933-0219(25)00047-9. doi: 10.1016/j.mucimm.2025.04.009. Online ahead of print. ABSTRACT Dyslipidemia, characterized by altered lipid profiles, influences host immune responses against infections, including Mycobacterium tuberculosis (Mtb). While the effects of dyslipidemia on conventional T cell responses are well documented, its impact on group 1-CD1 restricted T cells, a distinct subset of lipid antigen-specific … Read more

Mucosal Immunol. 2025 May 2:S1933-0219(25)00046-7. doi: 10.1016/j.mucimm.2025.04.008. Online ahead of print. ABSTRACT Influenza A virus (IAV) infections trigger asthma attacks and cause airway hyperresponsiveness (AHR) in murine models. However, the mechanism by which AHR is induced remains to be fully elucidated. Here, we show that targeting the interleukin (IL)-33 suppression of tumorigenicity 2 (ST2) receptor … Read more

Mucosal Immunol. 2025 Apr 25:S1933-0219(25)00043-1. doi: 10.1016/j.mucimm.2025.04.005. Online ahead of print. ABSTRACT Pregnancies rely upon the balance between fetal and maternal immune systems. Employing imaging mass cytometry, this study creates a spatial map landscape to unravel the cellular dynamics within the placental villi (PV). Consistent with previous data we report structural remodeling in PV, highlighted … Read more