Publicaciones
Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance
Most bNAbs from chronically HCV-infected people use the VH1-69 gene segment and target the envelope glycoprotein E2 front layer. Ogega et al. isolate bNAbs from an elite neutralizer who spontaneously cleared HCV. These bNAbs use a variety of VH genes a…
Aerobic glycolysis enables the effector differentiation potential of stem-like CD4<sup>+</sup> T cells to combat cancer
Cellular & Molecular Immunology, Published online: 21 March 2024; doi:10.1038/s41423-024-01154-wAerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer
Therapeutic efficacy and safety of JAK inhibitors in treating polymyositis/dermatomyositis: a single-arm systemic meta-analysis
IntroductionWe performed a single-arm meta-analysis to evaluate the efficacy and safety of JAK inhibitors in the treatment of dermatomyositis (DM)/ polymyositis (PM).MethodsRelevant studies from four databases were systematically searched until April 2…
Advancements in γδT cell engineering: paving the way for enhanced cancer immunotherapy
Comprising only 1-10% of the circulating T cell population, γδT cells play a pivotal role in cancer immunotherapy due to their unique amalgamation of innate and adaptive immune features. These cells can secrete cytokines, including interferon-γ (IFN-γ)…
Circulating T cells: a promising biomarker of anti-PD-(L)1 therapy
Anti-PD-(L)1 therapy has shown great efficacy in some patients with cancer. However, a significant proportion of patients with cancer do not respond to it. Another unmet clinical need for anti-PD-(L)1 therapy is the dynamic monitoring of treatment effe…
Identification of B cell subsets based on antigen receptor sequences using deep learning
B cell receptors (BCRs) denote antigen specificity, while corresponding cell subsets indicate B cell functionality. Since each B cell uniquely encodes this combination, physical isolation and subsequent processing of individual B cells become indispens…
Prevalence and duration of SARS-CoV-2 fecal shedding in breastfeeding dyads following maternal COVID-19 diagnosis
BackgroundThere is a paucity of data on the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in feces of lactating women with coronavirus disease 2019 (COVID-19) and their breastfed infants as well as associations between fecal …
Reduced serum IgG galactosylation is associated with increased inflammation during relapses of neuromyelitis optica spectrum disorders
Background and ObjectivePost-translational modifications of antibodies, with a specific focus on galactosylation, have garnered increasing attention in the context of understanding the pathogenesis and therapeutic implications of autoimmune diseases. H…
Identification of a new genetic variant (G231N, E232T, N235D) of peptidylarginine deiminase from P. gingivalis in advanced periodontitis
Chronic periodontitis (CP), an inflammatory disease of periodontal tissues driven by a dysbiotic subgingival bacterial biofilm, is also associated with several systemic diseases, including rheumatoid arthritis (RA). Porphyromonas gingivalis, one of the…