Seminars in Immunology

Semin Immunol. 2025 Aug 14;79:101981. doi: 10.1016/j.smim.2025.101981. Online ahead of print. ABSTRACT Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) occur in more than half of patients with SLE, with symptoms including fatigue, anxiety, depression, pain, psychosis, and cognitive dysfunction. These symptoms are often present at the time of diagnosis of SLE and can be insidious. … Read more

Semin Immunol. 2025 Aug 7;79:101982. doi: 10.1016/j.smim.2025.101982. Online ahead of print. ABSTRACT Approximately 20 % of the global population reports adverse reactions to foods, with food allergy and celiac disease being the most well-characterized conditions. Although they involve distinct pathological mechanisms, both are recognized as antigen-driven immune disorders and potentially sharing unidentified genetic and environmental … Read more

Semin Immunol. 2025 Jul 29;79:101980. doi: 10.1016/j.smim.2025.101980. Online ahead of print. ABSTRACT Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor and is currently a major cause of cancer-related mortality worldwide. The arrival of immune checkpoint inhibitors (ICI), and their combination with anti-VEGF/VEGFR antibodies, has transformed the treatment of patients with advanced HCC. Still, … Read more

Semin Immunol. 2025 Jul 21;79:101979. doi: 10.1016/j.smim.2025.101979. Online ahead of print. ABSTRACT Early studies on T helper (Th) 9 cells and their specific cytokine IL-9 mainly focused on the field of allergic diseases. In addition to pathological studies, IL-9 can also affect the normal development and various functions of T cells and B cells. In … Read more

Semin Immunol. 2025 Jul 18;79:101978. doi: 10.1016/j.smim.2025.101978. Online ahead of print. ABSTRACT All known life forms feature a dense ensemble of cell surface and extracellular glycans. In vertebrates this includes a high density of sialic acids (Sias), a family of acidic sugars typically capping glycans of cell surface or secreted glycoproteins and glycolipids. Since Sia … Read more

Semin Immunol. 2025 Jun 25;79:101977. doi: 10.1016/j.smim.2025.101977. Online ahead of print. ABSTRACT Oncolytic viruses have played a pioneering role in establishing immunotherapies as the next generation of anti-cancer medicines. Recent works have highlighted the impact the tumour microenvironment has on the efficacy of immunotherapies like oncolytic viruses, as well as the ability of oncolytic viruses … Read more

Semin Immunol. 2025 Jun 24;79:101976. doi: 10.1016/j.smim.2025.101976. Online ahead of print. ABSTRACT The complement system, a key component of innate immunity, has a paradoxical role in cancer, acting both as a tumor suppressor and a promoter. While traditionally recognized for its extracellular immune functions, recent discoveries highlight non-canonical, intracellular roles in tumor progression. These findings … Read more

Semin Immunol. 2025 Jun 23;79:101975. doi: 10.1016/j.smim.2025.101975. Online ahead of print. ABSTRACT The pivotal involvement of the host immune system in cancer therapy has dramatically reshaped therapeutic paradigms, inaugurating the era of immunotherapy. Nonetheless, antigen-specific immunotherapies encounter substantial hurdles within the highly immunosuppressive microenvironment of glioblastoma (GBM), which thwarts antitumor T-cell immunity. Oncolytic viruses (OVs), … Read more

Semin Immunol. 2025 Jun 16;79:101974. doi: 10.1016/j.smim.2025.101974. Online ahead of print. ABSTRACT Protein-glycan interactions, mediated by lectins, are essential for diverse physiological processes, including glycoprotein processing, cell adhesion, communication, signaling, and immune recognition. Lectins, classified into families like C-type, I-type, F-type, and galectins, recognize specific glycans on macromolecules through their carbohydrate recognition domains (CRDs). Galectins, … Read more

Semin Immunol. 2025 May 20;78:101965. doi: 10.1016/j.smim.2025.101965. Online ahead of print. ABSTRACT Emerging observations at the molecular, cellular, and organismal levels have unveiled critical roles for glycans in regulating a broad range of innate and adaptive immune cell processes. Through interactions with various families of glycan-binding proteins, including galectins, C-type lectins, and siglecs, glycans shape … Read more