Seminars in Immunology

Semin Immunol. 2025 Aug 7;79:101982. doi: 10.1016/j.smim.2025.101982. Online ahead of print. ABSTRACT Approximately 20 % of the global population reports adverse reactions to foods, with food allergy and celiac disease being the most well-characterized conditions. Although they involve distinct pathological mechanisms, both are recognized as antigen-driven immune disorders and potentially sharing unidentified genetic and environmental … Read more

Semin Immunol. 2025 Jul 29;79:101980. doi: 10.1016/j.smim.2025.101980. Online ahead of print. ABSTRACT Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor and is currently a major cause of cancer-related mortality worldwide. The arrival of immune checkpoint inhibitors (ICI), and their combination with anti-VEGF/VEGFR antibodies, has transformed the treatment of patients with advanced HCC. Still, … Read more

Semin Immunol. 2025 Jul 21;79:101979. doi: 10.1016/j.smim.2025.101979. Online ahead of print. ABSTRACT Early studies on T helper (Th) 9 cells and their specific cytokine IL-9 mainly focused on the field of allergic diseases. In addition to pathological studies, IL-9 can also affect the normal development and various functions of T cells and B cells. In … Read more

Semin Immunol. 2025 Jul 18;79:101978. doi: 10.1016/j.smim.2025.101978. Online ahead of print. ABSTRACT All known life forms feature a dense ensemble of cell surface and extracellular glycans. In vertebrates this includes a high density of sialic acids (Sias), a family of acidic sugars typically capping glycans of cell surface or secreted glycoproteins and glycolipids. Since Sia … Read more

Semin Immunol. 2025 Jun 25;79:101977. doi: 10.1016/j.smim.2025.101977. Online ahead of print. ABSTRACT Oncolytic viruses have played a pioneering role in establishing immunotherapies as the next generation of anti-cancer medicines. Recent works have highlighted the impact the tumour microenvironment has on the efficacy of immunotherapies like oncolytic viruses, as well as the ability of oncolytic viruses … Read more

Semin Immunol. 2025 Jun 24;79:101976. doi: 10.1016/j.smim.2025.101976. Online ahead of print. ABSTRACT The complement system, a key component of innate immunity, has a paradoxical role in cancer, acting both as a tumor suppressor and a promoter. While traditionally recognized for its extracellular immune functions, recent discoveries highlight non-canonical, intracellular roles in tumor progression. These findings … Read more

Semin Immunol. 2025 Jun 23;79:101975. doi: 10.1016/j.smim.2025.101975. Online ahead of print. ABSTRACT The pivotal involvement of the host immune system in cancer therapy has dramatically reshaped therapeutic paradigms, inaugurating the era of immunotherapy. Nonetheless, antigen-specific immunotherapies encounter substantial hurdles within the highly immunosuppressive microenvironment of glioblastoma (GBM), which thwarts antitumor T-cell immunity. Oncolytic viruses (OVs), … Read more

Semin Immunol. 2025 Jun 16;79:101974. doi: 10.1016/j.smim.2025.101974. Online ahead of print. ABSTRACT Protein-glycan interactions, mediated by lectins, are essential for diverse physiological processes, including glycoprotein processing, cell adhesion, communication, signaling, and immune recognition. Lectins, classified into families like C-type, I-type, F-type, and galectins, recognize specific glycans on macromolecules through their carbohydrate recognition domains (CRDs). Galectins, … Read more

Semin Immunol. 2025 May 20;78:101965. doi: 10.1016/j.smim.2025.101965. Online ahead of print. ABSTRACT Emerging observations at the molecular, cellular, and organismal levels have unveiled critical roles for glycans in regulating a broad range of innate and adaptive immune cell processes. Through interactions with various families of glycan-binding proteins, including galectins, C-type lectins, and siglecs, glycans shape … Read more

Semin Immunol. 2025 May 15;78:101963. doi: 10.1016/j.smim.2025.101963. Online ahead of print. ABSTRACT The tumor microenvironment (TME) consists of various immune and non-immune cells, along with proteins from different origins, and plays a crucial role in tumor development, treatment response, and patient prognosis. Complement system is a key player in the TME. It is a proteolytic … Read more