Seminars in Immunology

Semin Immunol. 2025 Sep 23;80:101994. doi: 10.1016/j.smim.2025.101994. Online ahead of print. ABSTRACT Oncolytic virotherapy (OVT) is a novel approach to cancer treatment that utilizes viruses to infect and destroy tumor cells selectively. Beyond direct oncolysis, OVT significantly reshapes the tumor microenvironment (TME), activating the adaptive immune system to generate robust and durable anti-tumor immunity. This … Read more

Semin Immunol. 2025 Aug 30;80:101984. doi: 10.1016/j.smim.2025.101984. Online ahead of print. ABSTRACT The intestinal mucosa employs a diverse set of defense mechanisms-from mucosal barrier regulation to immunoregulatory pathways-to maintain homeostasis despite constant exposure to microbial and dietary antigens. Failure to establish immune tolerance to food antigens can lead to pathological conditions such as celiac disease … Read more

Semin Immunol. 2025 Aug 28;79:101983. doi: 10.1016/j.smim.2025.101983. Online ahead of print. ABSTRACT In Type 1 diabetes (T1D), pancreatic β cells are progressively lost, resulting in insulin insufficiency. Although exogenous insulin is essential for disease management, it is not a cure, and inadequate glycemic control continues to result in long-term complications. Thus, there is a need … Read more

Semin Immunol. 2025 Aug 14;79:101981. doi: 10.1016/j.smim.2025.101981. Online ahead of print. ABSTRACT Neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) occur in more than half of patients with SLE, with symptoms including fatigue, anxiety, depression, pain, psychosis, and cognitive dysfunction. These symptoms are often present at the time of diagnosis of SLE and can be insidious. … Read more

Semin Immunol. 2025 Aug 7;79:101982. doi: 10.1016/j.smim.2025.101982. Online ahead of print. ABSTRACT Approximately 20 % of the global population reports adverse reactions to foods, with food allergy and celiac disease being the most well-characterized conditions. Although they involve distinct pathological mechanisms, both are recognized as antigen-driven immune disorders and potentially sharing unidentified genetic and environmental … Read more

Semin Immunol. 2025 Jul 29;79:101980. doi: 10.1016/j.smim.2025.101980. Online ahead of print. ABSTRACT Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor and is currently a major cause of cancer-related mortality worldwide. The arrival of immune checkpoint inhibitors (ICI), and their combination with anti-VEGF/VEGFR antibodies, has transformed the treatment of patients with advanced HCC. Still, … Read more

Semin Immunol. 2025 Jul 21;79:101979. doi: 10.1016/j.smim.2025.101979. Online ahead of print. ABSTRACT Early studies on T helper (Th) 9 cells and their specific cytokine IL-9 mainly focused on the field of allergic diseases. In addition to pathological studies, IL-9 can also affect the normal development and various functions of T cells and B cells. In … Read more

Semin Immunol. 2025 Jul 18;79:101978. doi: 10.1016/j.smim.2025.101978. Online ahead of print. ABSTRACT All known life forms feature a dense ensemble of cell surface and extracellular glycans. In vertebrates this includes a high density of sialic acids (Sias), a family of acidic sugars typically capping glycans of cell surface or secreted glycoproteins and glycolipids. Since Sia … Read more

Semin Immunol. 2025 Jun 25;79:101977. doi: 10.1016/j.smim.2025.101977. Online ahead of print. ABSTRACT Oncolytic viruses have played a pioneering role in establishing immunotherapies as the next generation of anti-cancer medicines. Recent works have highlighted the impact the tumour microenvironment has on the efficacy of immunotherapies like oncolytic viruses, as well as the ability of oncolytic viruses … Read more

Semin Immunol. 2025 Jun 24;79:101976. doi: 10.1016/j.smim.2025.101976. Online ahead of print. ABSTRACT The complement system, a key component of innate immunity, has a paradoxical role in cancer, acting both as a tumor suppressor and a promoter. While traditionally recognized for its extracellular immune functions, recent discoveries highlight non-canonical, intracellular roles in tumor progression. These findings … Read more