Seminars in Immunology

Semin Immunol. 2025 Jun 23;79:101975. doi: 10.1016/j.smim.2025.101975. Online ahead of print. ABSTRACT The pivotal involvement of the host immune system in cancer therapy has dramatically reshaped therapeutic paradigms, inaugurating the era of immunotherapy. Nonetheless, antigen-specific immunotherapies encounter substantial hurdles within the highly immunosuppressive microenvironment of glioblastoma (GBM), which thwarts antitumor T-cell immunity. Oncolytic viruses (OVs), … Read more

Semin Immunol. 2025 Jun 16;79:101974. doi: 10.1016/j.smim.2025.101974. Online ahead of print. ABSTRACT Protein-glycan interactions, mediated by lectins, are essential for diverse physiological processes, including glycoprotein processing, cell adhesion, communication, signaling, and immune recognition. Lectins, classified into families like C-type, I-type, F-type, and galectins, recognize specific glycans on macromolecules through their carbohydrate recognition domains (CRDs). Galectins, … Read more

Semin Immunol. 2025 May 20;78:101965. doi: 10.1016/j.smim.2025.101965. Online ahead of print. ABSTRACT Emerging observations at the molecular, cellular, and organismal levels have unveiled critical roles for glycans in regulating a broad range of innate and adaptive immune cell processes. Through interactions with various families of glycan-binding proteins, including galectins, C-type lectins, and siglecs, glycans shape … Read more

Semin Immunol. 2025 May 15;78:101963. doi: 10.1016/j.smim.2025.101963. Online ahead of print. ABSTRACT The tumor microenvironment (TME) consists of various immune and non-immune cells, along with proteins from different origins, and plays a crucial role in tumor development, treatment response, and patient prognosis. Complement system is a key player in the TME. It is a proteolytic … Read more

Semin Immunol. 2025 May 14;78:101962. doi: 10.1016/j.smim.2025.101962. Online ahead of print. ABSTRACT Narcolepsy type 1 (NT1) is a chronic orphan neurological sleep disorder characterized by the loss of hypocretin-producing neurons in the lateral hypothalamus, which play a crucial role in wakefulness. Given the genetic association with the HLA-DQB1 * 06:02 allele and environmental links with … Read more

Semin Immunol. 2025 May 9;78:101964. doi: 10.1016/j.smim.2025.101964. Online ahead of print. ABSTRACT Vaccines induce quantitively and qualitatively different effector responses between populations but also between individuals within populations. Several factors are known to affect the success of vaccination, including age, gender, co-infections (e.g. HIV), pre-existing inflammatory status and co-morbidities such as type 2 diabetes mellitus … Read more

Semin Immunol. 2025 Apr 28;78:101961. doi: 10.1016/j.smim.2025.101961. Online ahead of print. ABSTRACT Celiac disease and food-allergy are both food-related chronic immune disorders with a common pathogenic link being breakdown in the gut tolerance to otherwise innocuous food antigens. Notwithstanding the similarities, there are significant differences in the pathogenesis of both disorders, which translates to variations … Read more

Semin Immunol. 2025 Apr 27;78:101956. doi: 10.1016/j.smim.2025.101956. Online ahead of print. ABSTRACT Cancer is a leading cause of morbidity and mortality worldwide. The development of immune checkpoint inhibitors (ICI) has revolutionised cancer therapy, and patients who were previously incurable can now have excellent responses. These therapies work by blocking inhibitory immune pathways, like cytotoxic T … Read more

Semin Immunol. 2025 Apr 26;78:101957. doi: 10.1016/j.smim.2025.101957. Online ahead of print. ABSTRACT In response to stress stimuli, cells have evolved various mechanisms to integrate internal and external signals to achieve dynamic homeostasis. Lysine acetyltransferase (KATs) and deacetyltransferase (KDACs) are the key modulators of epigenetic modifications, enabling cells to modulate cellular responses through the acetylation and … Read more

Semin Immunol. 2025 Apr 23;78:101960. doi: 10.1016/j.smim.2025.101960. Online ahead of print. ABSTRACT Coeliac disease and food allergy management primarily relies on the strict avoidance of dietary antigens. This approach is challenging to maintain in real-world settings and in food allergy carries the risk of life-threatening anaphylaxis. Despite their distinct pathogenesis, both disorders are driven by … Read more