Seminars in Immunology

Semin Immunol. 2025 Mar 27;78:101945. doi: 10.1016/j.smim.2025.101945. Online ahead of print. ABSTRACT Ever since the discovery of pathogenic aquaporin 4-specific antibodies in the serum of patients with neuromyelitis optica spectrum disorders current knowledge about clinical observations and diagnosis, and about the underlying pathology and resulting therapies have been put forward in excellent reviews and primary … Read more

Semin Immunol. 2025 Mar 14;78:101944. doi: 10.1016/j.smim.2025.101944. Online ahead of print. ABSTRACT MOG antibody-associated disease (MOGAD), an inflammatory demyelinating pathology, is typically associated with the clinical phenotypes acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), or transverse myelitis (TM). The mainstay of diagnosis is detection of antibodies targeting oligodendrocyte-expressed MOG (MOG-IgG). MOG-IgG-mediated demyelination occurs via complement-dependent … Read more

Semin Immunol. 2025 Mar 13;78:101941. doi: 10.1016/j.smim.2025.101941. Online ahead of print. ABSTRACT In celiac disease (CeD), dietary gluten serves as the driver for a comparatively well characterized small bowel mucosal immune response that generally results in small bowel mucosal villous atrophy and crypt hyperplasia along with a disease-specific transglutaminase 2 (TG2) targeting autoantibody response. Individuals … Read more

Semin Immunol. 2025 Mar 8;78:101933. doi: 10.1016/j.smim.2025.101933. Online ahead of print. ABSTRACT Itch is an unpleasant sensation that is encoded by specific sensory neurons called pruriceptors. Itch is associated with almost all skin diseases. Recent studies revealed that many itchy skin diseases are associated with microbiome dysbiosis. Pathogenic microbes secrete proteases and toxins to invade … Read more

Semin Immunol. 2025 Jan 17;77:101931. doi: 10.1016/j.smim.2025.101931. Online ahead of print. ABSTRACT Cancer remains a formidable global health challenge requiring the continued exploration of innovative therapeutic approaches. While traditional treatment strategies including surgery, chemotherapy, and radiation therapy have had some success, primarily in early-stage disease, the quest for more targeted, personalized, safer, and effective therapies … Read more

Semin Immunol. 2025 Jan 10;77:101928. doi: 10.1016/j.smim.2024.101928. Online ahead of print. ABSTRACT Once regarded as distinct systems, the nervous system and the immune system are now recognized for their complex interactions within the barrier tissues. The neuroimmune circuitry comprises a dual-network system that detects external and internal disturbances, providing critical information to tailor a context-specific … Read more

Semin Immunol. 2025 Jan 10;77:101932. doi: 10.1016/j.smim.2025.101932. Online ahead of print. NO ABSTRACT PMID:39798210 | DOI:10.1016/j.smim.2025.101932

Semin Immunol. 2025 Jan 9;77:101930. doi: 10.1016/j.smim.2025.101930. Online ahead of print. ABSTRACT In recent years, wheat- and gluten-free diets have increased in demand due to reported increases in various conditions reported to be driven by ingredients of these food products. Celiac disease, wheat allergy and non-celiac wheat sensitivity constitute the three main categories of wheat-related … Read more

Semin Immunol. 2025 Jan 9;77:101929. doi: 10.1016/j.smim.2025.101929. Online ahead of print. ABSTRACT Ground-breaking awareness has been reached about the intricate and dynamic connection between developing tumors and the host immune system. Being a powerful arm of innate immunity and a functional bridge with adaptive immunity, the complement system (C) has also emerged as a pivotal … Read more

Semin Immunol. 2025 Jan 6;77:101927. doi: 10.1016/j.smim.2024.101927. Online ahead of print. ABSTRACT The complement system is increasingly recognised as a key player in tumour progression and response to cancer treatment. Cytotoxic therapies, including chemo- and radiotherapy are standard-of-care for the majority of cancer patients. Cytotoxics have been found to alter the expression of complement system … Read more