Seminars in Immunology

Semin Immunol. 2025 Jan 17;77:101931. doi: 10.1016/j.smim.2025.101931. Online ahead of print. ABSTRACT Cancer remains a formidable global health challenge requiring the continued exploration of innovative therapeutic approaches. While traditional treatment strategies including surgery, chemotherapy, and radiation therapy have had some success, primarily in early-stage disease, the quest for more targeted, personalized, safer, and effective therapies … Read more

Semin Immunol. 2025 Jan 10;77:101928. doi: 10.1016/j.smim.2024.101928. Online ahead of print. ABSTRACT Once regarded as distinct systems, the nervous system and the immune system are now recognized for their complex interactions within the barrier tissues. The neuroimmune circuitry comprises a dual-network system that detects external and internal disturbances, providing critical information to tailor a context-specific … Read more

Semin Immunol. 2025 Jan 10;77:101932. doi: 10.1016/j.smim.2025.101932. Online ahead of print. NO ABSTRACT PMID:39798210 | DOI:10.1016/j.smim.2025.101932

Semin Immunol. 2025 Jan 9;77:101930. doi: 10.1016/j.smim.2025.101930. Online ahead of print. ABSTRACT In recent years, wheat- and gluten-free diets have increased in demand due to reported increases in various conditions reported to be driven by ingredients of these food products. Celiac disease, wheat allergy and non-celiac wheat sensitivity constitute the three main categories of wheat-related … Read more

Semin Immunol. 2025 Jan 9;77:101929. doi: 10.1016/j.smim.2025.101929. Online ahead of print. ABSTRACT Ground-breaking awareness has been reached about the intricate and dynamic connection between developing tumors and the host immune system. Being a powerful arm of innate immunity and a functional bridge with adaptive immunity, the complement system (C) has also emerged as a pivotal … Read more

Semin Immunol. 2025 Jan 6;77:101927. doi: 10.1016/j.smim.2024.101927. Online ahead of print. ABSTRACT The complement system is increasingly recognised as a key player in tumour progression and response to cancer treatment. Cytotoxic therapies, including chemo- and radiotherapy are standard-of-care for the majority of cancer patients. Cytotoxics have been found to alter the expression of complement system … Read more

Semin Immunol. 2024 Dec 31;77:101922. doi: 10.1016/j.smim.2024.101922. Online ahead of print. ABSTRACT The complement system plays an integral role in both innate and adaptive immune responses. Beyond its protective function against infections, complement is also known to influence tumor immunity, where its activation can either promote tumor progression or mediate tumor cell destruction, depending on … Read more

Semin Immunol. 2024 Dec 24;77:101926. doi: 10.1016/j.smim.2024.101926. Online ahead of print. ABSTRACT In this review, we aim to explore the multifaceted roles of galectins in host defense from a broader perspective, particularly regarding their functions when host integrity is compromised. Numerous comprehensive reviews on galectin functions in immunity have already been published. For researchers new … Read more

Semin Immunol. 2024 Dec 19;77:101925. doi: 10.1016/j.smim.2024.101925. Online ahead of print. ABSTRACT Cell surface complex carbohydrates, known as glycans, are positioned to be the first point of contact between two cells. Indeed, interactions between glycans with glycan-binding can modulate cell-cell interactions. This concept is particularly relevant for immune cells, which use an array of glycan-binding … Read more

Semin Immunol. 2024 Dec 18;77:101921. doi: 10.1016/j.smim.2024.101921. Online ahead of print. ABSTRACT The complement system, a key component of innate immunity, is involved in seemingly contradictory aspects of tumor progression and cancer therapy. It can act as an immune effector against cancer and modulate the antitumor activity of certain therapeutic antibodies, but it can also … Read more