Seminars in Immunology

Semin Immunol. 2025 Jan 9;77:101929. doi: 10.1016/j.smim.2025.101929. Online ahead of print. ABSTRACT Ground-breaking awareness has been reached about the intricate and dynamic connection between developing tumors and the host immune system. Being a powerful arm of innate immunity and a functional bridge with adaptive immunity, the complement system (C) has also emerged as a pivotal … Read more

Semin Immunol. 2025 Jan 6;77:101927. doi: 10.1016/j.smim.2024.101927. Online ahead of print. ABSTRACT The complement system is increasingly recognised as a key player in tumour progression and response to cancer treatment. Cytotoxic therapies, including chemo- and radiotherapy are standard-of-care for the majority of cancer patients. Cytotoxics have been found to alter the expression of complement system … Read more

Semin Immunol. 2024 Dec 31;77:101922. doi: 10.1016/j.smim.2024.101922. Online ahead of print. ABSTRACT The complement system plays an integral role in both innate and adaptive immune responses. Beyond its protective function against infections, complement is also known to influence tumor immunity, where its activation can either promote tumor progression or mediate tumor cell destruction, depending on … Read more

Semin Immunol. 2024 Dec 24;77:101926. doi: 10.1016/j.smim.2024.101926. Online ahead of print. ABSTRACT In this review, we aim to explore the multifaceted roles of galectins in host defense from a broader perspective, particularly regarding their functions when host integrity is compromised. Numerous comprehensive reviews on galectin functions in immunity have already been published. For researchers new … Read more

Semin Immunol. 2024 Dec 19;77:101925. doi: 10.1016/j.smim.2024.101925. Online ahead of print. ABSTRACT Cell surface complex carbohydrates, known as glycans, are positioned to be the first point of contact between two cells. Indeed, interactions between glycans with glycan-binding can modulate cell-cell interactions. This concept is particularly relevant for immune cells, which use an array of glycan-binding … Read more

Semin Immunol. 2024 Dec 18;77:101921. doi: 10.1016/j.smim.2024.101921. Online ahead of print. ABSTRACT The complement system, a key component of innate immunity, is involved in seemingly contradictory aspects of tumor progression and cancer therapy. It can act as an immune effector against cancer and modulate the antitumor activity of certain therapeutic antibodies, but it can also … Read more

Semin Immunol. 2024 Nov 26;76:101913. doi: 10.1016/j.smim.2024.101913. Online ahead of print. ABSTRACT The immune system is a complex network of highly specialized microenvironments, denominated niches, which arise from dynamic interactions between immune and parenchymal cells as well as acellular components such as structural elements and local molecular signals. A critical, yet underexplored, layer shaping these … Read more

Semin Immunol. 2024 Nov 23;76:101911. doi: 10.1016/j.smim.2024.101911. Online ahead of print. ABSTRACT Galectins, a family of carbohydrate-binding proteins, play crucial roles in the host-virus interaction landscape. This review explores the multifaceted contributions of endogenous galectins to various stages of the viral lifecycle, including attachment, replication, assembly, and release of progeny virions. Recent studies have indicated … Read more

Semin Immunol. 2024 Nov 22;76:101912. doi: 10.1016/j.smim.2024.101912. Online ahead of print. ABSTRACT The complement system plays crucial roles in both innate and adaptive immune responses, facilitating the elimination of pathogens such as microorganisms and damaged cells, including cancer cells. It is tightly regulated and integrated with cell-mediated immunity. In the tumor microenvironment, the complement system … Read more

Semin Immunol. 2024 Nov 6;74-75:101901. doi: 10.1016/j.smim.2024.101901. Online ahead of print. ABSTRACT Inborn errors of immunity (IEI) encompass a group of disorders with a strong genetic component. Prompt and accurate diagnosis of these disorders is essential for effective clinical management. Next-generation sequencing (NGS) has significantly enhanced the diagnostic process by offering a comprehensive and scalable … Read more