Seminars in Immunology

Semin Immunol. 2024 Oct 25;74-75:101900. doi: 10.1016/j.smim.2024.101900. Online ahead of print. ABSTRACT Dendritic cells (DCs) are crucial for initiating immune responses against tumours by presenting antigens to T cells. Glycosylation, particularly sialylation, plays a significant role in regulating cell functions, by modulating protein folding and signalling. This review aimed to provide a comprehensive overview of … Read more

Semin Immunol. 2024 Oct 19;74-75:101893. doi: 10.1016/j.smim.2024.101893. Online ahead of print. ABSTRACT Immunotherapy, including immune checkpoint inhibition, has transformed cancer therapy in recent years, providing new and potentially curative options for patients with even advanced disease. However, only a minority of patients achieve long-lasting remissions, and resistance to immune checkpoint inhibition is common. Recently, the … Read more

Semin Immunol. 2024 Oct 14;74-75:101889. doi: 10.1016/j.smim.2024.101889. Online ahead of print. ABSTRACT Hematopoiesis- the formation of blood cell components- continually replenishes the blood system during embryonic development and postnatal lifespans. This coordinated process requires the synchronized action of a broad range of cell surface associated proteins and soluble mediators, including growth factors, cytokines and lectins. … Read more

Semin Immunol. 2024 Oct 14;74-75:101892. doi: 10.1016/j.smim.2024.101892. Online ahead of print. ABSTRACT ABO blood group antigens, which are complex carbohydrate moieties, and the first human polymorphisms identified, are critical in transfusion medicine and transplantation. Despite their discovery over a century ago, significant questions remain about the development of anti-ABO antibodies and the structural features of … Read more

Semin Immunol. 2024 Oct 9;73:101891. doi: 10.1016/j.smim.2024.101891. Online ahead of print. ABSTRACT The human gut microbiota is home to a diverse collection of microorganisms that has co-evolved with the host immune system in which host-microbiota interactions are essential to preserve health and homeostasis. Evidence suggests that the perturbation of this symbiotic host-microbiome relationship contributes to … Read more

Semin Immunol. 2024 Oct 8;73:101890. doi: 10.1016/j.smim.2024.101890. Online ahead of print. ABSTRACT As the global population ages at an unprecedented rate, the prevalence of age-related diseases is increasing, making inflammaging – a phenomenon characterized by a chronic, low-grade inflammatory state that follows aging – a significant concern. Understanding the mechanisms of inflammaging and its impact … Read more

Semin Immunol. 2024 Oct 1;73:101887. doi: 10.1016/j.smim.2024.101887. Online ahead of print. ABSTRACT The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors expressed widely on cells of the hematopoietic system. Siglecs recognize terminal sialic acid residues on glycans and often initiate intracellular signaling upon ligation. Cells can express several Siglec family members concurrently with … Read more

Semin Immunol. 2024 Mar;72:101866. doi: 10.1016/j.smim.2024.101866. Epub 2024 Mar 5. NO ABSTRACT PMID:38442534 | DOI:10.1016/j.smim.2024.101866

Semin Immunol. 2024 Mar;72:101864. doi: 10.1016/j.smim.2024.101864. Epub 2024 Jan 31. ABSTRACT Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor – in distinct cancers, subcohorts and individual patients – is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute … Read more

Semin Immunol. 2024 Sep 27;73:101888. doi: 10.1016/j.smim.2024.101888. Online ahead of print. NO ABSTRACT PMID:39340930 | DOI:10.1016/j.smim.2024.101888