J Immunol. 2025 Aug 1;214(8):1881-1888. doi: 10.1093/jimmun/vkaf128. ABSTRACT Programmed cell death is an integral arm of immunity, especially in response to intracellular pathogen infection, for the release of inflammatory mediators, and the clearance of pathogen-infected cells. In the central nervous system, cell death as a form of immunity may seem paradoxical; neuronal health is critical … Read more
J Immunol. 2025 Aug 1;214(8):1863-1871. doi: 10.1093/jimmun/vkaf116. ABSTRACT The lymphatics are a system of vessels that traffic lymph and immune cells throughout the body to maintain fluid balance and aid in the response to infection and injury. Although the lymphatics are often thought of as a passive conduit, this review will demonstrate that the lymphatics … Read more
J Immunol. 2025 Aug 28:vkaf208. doi: 10.1093/jimmun/vkaf208. Online ahead of print. ABSTRACT The main limitations of cancer treatment with high doses of recombinant interleukin 2 (IL-2) are high toxicity and the undesired expansion of regulatory T cells. The generation of IL-2 mutated variants (muteins) with changes in the affinity for different chains of the IL-2 … Read more
J Immunol. 2025 Aug 28:vkaf177. doi: 10.1093/jimmun/vkaf177. Online ahead of print. ABSTRACT Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is required for appropriate cytokine expression in female but not male T helper 2 (Th2) cells. Malat1 deficiency impairs in vitro Th2 differentiation of … Read more
J Immunol. 2025 Aug 25:vkaf194. doi: 10.1093/jimmun/vkaf194. Online ahead of print. ABSTRACT As a result of the growing use of nuclear energy and radiation in medical interventions within the last decade, the potential for radiation exposure among the general public has increased. Exposure to high doses of radiation severely impairs the immune system, including CD8 … Read more
J Immunol. 2025 Aug 25:vkaf209. doi: 10.1093/jimmun/vkaf209. Online ahead of print. ABSTRACT Natural killer (NK) cells are innate immune lymphocytes important for host viral and tumor immunity. We investigated the requirement for ATP citrate lyase (ACLY) in NK cell function using an inducible genetic mouse model. ACLY regulates the citrate-malate shuttle, generating cytosolic acetyl-coenzyme A … Read more
J Immunol. 2025 Aug 24:vkaf187. doi: 10.1093/jimmun/vkaf187. Online ahead of print. ABSTRACT CD39 (encoded by ENTPD1) has emerged as a target for oncologic therapies. Inhibition of CD39 preserves extracellular adenosine triphosphate (eATP) and decreases extracellular adenosine (eADO) formation, thereby increasing the eATP/eADO ratio and promoting immune stimulation. RNA expression profiling of eATPases across all solid … Read more
J Immunol. 2025 Aug 24:vkaf211. doi: 10.1093/jimmun/vkaf211. Online ahead of print. ABSTRACT Sjögren syndrome-related interstitial lung disease (SS-ILD) is a severe complication associated with significant morbidity and mortality. Despite its clinical importance, the underlying pathogenesis remains poorly understood, and effective therapeutic strategies are limited. The development of a reliable animal model for SS-ILD is crucial … Read more
J Immunol. 2025 Aug 24:vkaf199. doi: 10.1093/jimmun/vkaf199. Online ahead of print. ABSTRACT Chimeric antigen receptor (CAR) T-cell therapy has proven to be a promising treatment for multiple types of cancer. Yet, the mechanisms regulating CAR T-cell function as well as the side effects remain an area of active research. The formation of the immunological synapse … Read more
J Immunol. 2025 Aug 24:vkaf207. doi: 10.1093/jimmun/vkaf207. Online ahead of print. ABSTRACT Allergic rhinitis (AR) is a respiratory airway disorder characterized by inflammation and barrier dysfunction. The transcription factor specificity protein 1 (SP1), a member of the Sp/Krüppel-like factor family, is known to be associated with inflammation. This study aimed to explore the impacts of … Read more
