J Immunol. 2025 Mar 17:vkaf044. doi: 10.1093/jimmun/vkaf044. Online ahead of print. NO ABSTRACT PMID:40096641 | DOI:10.1093/jimmun/vkaf044

J Immunol. 2025 Mar 17:vkaf024. doi: 10.1093/jimmun/vkaf024. Online ahead of print. ABSTRACT The prevalence of obesity and metabolic diseases have risen significantly over the past decades. Chronic inflammation in obesity is a link between obesity and secondary disease. While macrophages and monocytes are known to contribute to metabolic disease risk during diet exposure, little is … Read more

J Immunol. 2025 Mar 14:vkaf005. doi: 10.1093/jimmun/vkaf005. Online ahead of print. ABSTRACT Burkitt lymphoma (BL) is characterized by elevated levels of the enzyme activation-induced cytidine deaminase (AID), an enzyme critical for MYC translocation that is the hallmark of BL. Both EBV and Plasmodium falciparum malaria are cofactors in the etiology of BL. However, how these … Read more

J Immunol. 2025 Mar 14:vkae068. doi: 10.1093/jimmun/vkae068. Online ahead of print. ABSTRACT The virtually monomorphic antigen presentation molecule HLA-E can present self- and non-self peptides to the NKG2A/CD94 co-receptor inhibitory complex expressed on natural killer (NK) cells and to T cell receptors (TCRs) expressed on T cells. HLA-E presents self-peptides to NKG2A/CD94 to regulate tissue … Read more

J Immunol. 2025 Mar 13:vkaf001. doi: 10.1093/jimmun/vkaf001. Online ahead of print. ABSTRACT Type 1 innate lymphoid cells (ILC1s) respond to infections and tumors by producing IFN-γ. Although RAR-related orphan receptor α (RORα) is required for ILC2s and some ILC3s, its role in ILC1 development remains controversial. To investigate the role of RORα in ILC1s, we … Read more

J Immunol. 2025 Jan 1;214(1):104-114. doi: 10.1093/jimmun/vkae013. ABSTRACT Current influenza vaccines are not effective in conferring protection against antigenic variants and pandemics. To improve cross-protection of influenza vaccination, we developed a 5xM2e messenger RNA (mRNA) vaccine encoding the tandem repeat conserved ectodomain (M2e) of ion channel protein M2 derived from human, swine, and avian influenza … Read more

J Immunol. 2025 Jan 1;214(1):12-22. doi: 10.1093/jimmun/vkae014. ABSTRACT The CD2-depleting drug alefacept (LFA3-Ig) preserved beta cell function in new-onset type 1 diabetes (T1D) patients. The most promising biomarkers of response were late expansion of exhausted CD8 T cells and rare baseline inflammatory islet-reactive CD4 T cells, neither of which can be used to measure responses … Read more

J Immunol. 2025 Jan 1;214(1):141-152. doi: 10.1093/jimmun/vkae009. ABSTRACT Macrophages are important mediators of immune responses with critical roles in the recognition and clearance of pathogens, as well as in the resolution of inflammation and wound healing. The neuronal guidance cue SLIT2 has been widely studied for its effects on immune cell functions, most notably directional … Read more

J Immunol. 2025 Jan 1;214(1):153-166. doi: 10.1093/jimmun/vkae011. ABSTRACT Obesity is associated with comorbidities including type 2 diabetes, chronic nonhealing wounds, and psoriasis. Normally, skin homeostasis and repair is regulated through the production of cytokines and growth factors derived from skin-resident cells including epidermal γδ T cells. However, epidermal γδ T cells exhibit reduced proliferation and … Read more

J Immunol. 2025 Jan 1;214(1):167-179. doi: 10.1093/jimmun/vkae017. ABSTRACT The von Hippel-Lindau (VHL) tumor suppressor gene VHL is a classic tumor suppressor that has been identified in family members with clear cell renal cell carcinomas, central nervous system and retinal hemangioblastomas, phaeochromocytomas, and pancreatic neuroendocrine tumors. The well-defined function of VHL is to mediate proteasomal degradation … Read more