The Journal of Immunology

J Immunol. 2025 Aug 7:vkaf184. doi: 10.1093/jimmun/vkaf184. Online ahead of print. ABSTRACT Human macrophages differ from their mouse counterparts in multiple metabolic pathways, surface protein expression, and transcription factor biology. Monocyte-derived macrophages (MDMs) from blood are generally used to study human macrophage biology in vitro. However, the use of MDMs as a human macrophage model … Read more

J Immunol. 2025 Aug 1:vkaf094. doi: 10.1093/jimmun/vkaf094. Online ahead of print. ABSTRACT T cells play a pivotal role in the immune system, relying on their somatically rearranged T cell receptor (TCR) to recognize peptide-MHC complexes. A comprehensive and extensively used set of monoclonal antibodies (mAbs) against TCR variable regions was generated in the previous century. … Read more

J Immunol. 2025 Aug 1:vkaf112. doi: 10.1093/jimmun/vkaf112. Online ahead of print. ABSTRACT Total joint arthroplasty is the optimal method for end-stage osteoarticular diseases, but aseptic loosening reduces long-term success. Our prior research demonstrated that wear particles released from loosened prostheses activate macrophages to secrete proinflammatory cytokines, thereby promoting osteoclast formation and osteolysis. Gasdermin D (GSDMD), … Read more

J Immunol. 2025 Aug 1:vkaf151. doi: 10.1093/jimmun/vkaf151. Online ahead of print. ABSTRACT CD47 is an antiphagocytic (“don’t eat me”) signal expressed on all cells that inhibits programmed cell removal of self, and loss of this molecule by aging erythrocytes is associated with increased susceptibility to clearance by macrophages. Previously, we have demonstrated that absence of … Read more

J Immunol. 2025 Jul 1;214(7):1439-1440. doi: 10.1093/jimmun/vkaf145. NO ABSTRACT PMID:40740035 | DOI:10.1093/jimmun/vkaf145

J Immunol. 2025 Jul 29:vkaf172. doi: 10.1093/jimmun/vkaf172. Online ahead of print. ABSTRACT As we age, it becomes increasingly important to reduce the consumption of fatty foods. In mice, we also find that after consuming a high-fat diet, older mice develop insulin resistance more easily than young mice. But how aging renders both humans and mice … Read more

J Immunol. 2025 Jul 28:vkaf153. doi: 10.1093/jimmun/vkaf153. Online ahead of print. ABSTRACT Uterine natural killer cells have been thought to be critical for reproductive success, and their developmental origins remain unclear. Here, we demonstrate that Eomesodermin is a key transcription factor determining the lineage of tissue-resident NK cells within the uterus both at steady state … Read more

J Immunol. 2025 Jul 25:vkaf159. doi: 10.1093/jimmun/vkaf159. Online ahead of print. ABSTRACT In this study, monoclonal antibodies (mAbs) specific for sole immunoglobulin M (IgM) were generated, which allowed us to evaluate the kinetics of IgM+ B cell responses, assess the recruitment of these cells to the peritoneum following vaccination, and compare the dynamics of antigen-specific … Read more

J Immunol. 2025 Jul 26:vkaf143. doi: 10.1093/jimmun/vkaf143. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells recognize conserved microbial antigens presented by the non-polymorphic MR1 molecules and play important roles in barrier immunity. Enterotoxigenic E. coli (ETEC) is a major cause of diarrheal disease in children in lower-income countries and among travelers. Here we … Read more

J Immunol. 2025 Jul 26:vkaf144. doi: 10.1093/jimmun/vkaf144. Online ahead of print. ABSTRACT Infection with influenza virus remains a significant global health concern due to its ability to acquire mutations at key antigenic sites to escape antibody recognition. While germinal center (GC) and memory B cells have been well studied following influenza infection, the clonal dynamics … Read more