The Journal of Immunology

J Immunol. 2025 Jul 23:vkaf071. doi: 10.1093/jimmun/vkaf071. Online ahead of print. ABSTRACT Mortality from Pneumocystis pneumonia (PCP) continues to increase among non-human immunodeficiency virus (HIV) patients. Previous studies have reported that a considerable proportion of patients experience deterioration of their disease when glucocorticoids or other immunosuppressants are withdrawn. However, the underlying mechanisms responsible for this … Read more

J Immunol. 2025 Jul 22:vkaf122. doi: 10.1093/jimmun/vkaf122. Online ahead of print. ABSTRACT Cell transfer experiments complement the rigorous investigation of antiviral and antitumor functions of natural killer (NK) cells. Success in these endeavors is enhanced by expansion of small numbers of input NK cells driven by viral antigens or homeostatic proliferation in immunodeficient hosts. In … Read more

J Immunol. 2025 Jul 21:vkaf150. doi: 10.1093/jimmun/vkaf150. Online ahead of print. ABSTRACT Th1 and Th17 cell-mediated autoimmunity is critical for myocarditis induction. Antigen-presenting cell (APCs)-released interleukin (IL)-12 and IL-23 are implicated in the differentiation of Th1 and Th17 lineages. In this study, we utilized cardiac self-antigen myosin heavy chain alpha (α-MyHC)-pulsed bone marrow-derived dendritic cells … Read more

J Immunol. 2025 Jul 14:vkaf148. doi: 10.1093/jimmun/vkaf148. Online ahead of print. ABSTRACT Effective small molecule therapies are a major unmet need in triple-negative breast cancer. Therefore, we examined the mechanism of action of a novel cancer therapeutic target in preclinical mouse models focusing on the α7 nicotinic acetylcholine receptor (CHRNA7). E0771 breast tumor cells were … Read more

J Immunol. 2025 Jul 11:vkaf149. doi: 10.1093/jimmun/vkaf149. Online ahead of print. ABSTRACT Plasma cells (PC) produce antigen-specific antibodies following vaccination or infection, playing a vital role in protective immunity. Not all PC have equal lifespans, yet how lifespans are determined remains unknown. Here, we describe a system for the generation of persistent PC in mice … Read more

J Immunol. 2025 Jul 10:vkaf173. doi: 10.1093/jimmun/vkaf173. Online ahead of print. NO ABSTRACT PMID:40638862 | DOI:10.1093/jimmun/vkaf173

J Immunol. 2025 Jul 10:vkaf138. doi: 10.1093/jimmun/vkaf138. Online ahead of print. ABSTRACT Th2 cells must sense and adapt to the tissue milieu to provide protective host immunity and tissue repair. Here, we examined the mechanisms promoting Th2 cell differentiation and function within the small intestinal lamina propria. Single cell RNA-seq analyses of CD4+ T cells … Read more

J Immunol. 2025 Jul 9:vkaf131. doi: 10.1093/jimmun/vkaf131. Online ahead of print. ABSTRACT The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, a sensor of cytosolic DNA, orchestrates the production of proinflammatory cytokines, chemokines, and type I interferons (IFN-Is), thereby contributing to spontaneous tumor surveillance. Intratumoral delivery of synthetic STING agonists induces IFN-I-dependent tumor regression in … Read more

J Immunol. 2025 Jul 7:vkaf097. doi: 10.1093/jimmun/vkaf097. Online ahead of print. ABSTRACT Acute lung injury (ALI) post-lung transplantation (LT) is a major clinical challenge. This study investigates the role of exosomal miR-124-3p in modulating macrophage polarization and ameliorating ALI. Using male C57BL/6J mice, we established a left lung orthotopic transplantation model. Transcriptomic analysis revealed that … Read more

J Immunol. 2025 Jul 3:vkaf136. doi: 10.1093/jimmun/vkaf136. Online ahead of print. ABSTRACT Tissue stromal cells are composed of numerous cell types with phenotypical and functional heterogeneity. Apart from providing structural support, they are emerging as key orchestrators of both activation and repression of immune responses in tissue microenvironment. The underlying mechanisms by which stromal cells … Read more