The Journal of Immunology

The Type 1 Diabetes-Associated Single Nucleotide Polymorphism rs1990760 in IFIH1 Is Associated with Increased Basal Type I IFNs and IFN-stimulated Gene Expression

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J Immunol. 2024 Oct 7:ji2400344. doi: 10.4049/jimmunol.2400344. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) is a chronic autoimmune disease that is caused by a combination of genetic and environmental risk factors. In this study, we sought to determine whether a known genetic risk factor, the rs1990760 single nucleotide polymorphism (SNP) (A946T) in IFIH1, … Read more

In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells

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J Immunol. 2024 Oct 7:ji2400213. doi: 10.4049/jimmunol.2400213. Online ahead of print. ABSTRACT CD8+ T cells differentiate into two subpopulations in response to acute viral infection: memory precursor effector cells (MPECs) and short-lived effector cells (SLECs). MPECs and SLECs are epigenetically distinct; however, the epigenetic regulators required for formation of these subpopulations are mostly unknown. In … Read more

High-dimensional Immune Profiles and Machine Learning May Predict Acute Myeloid Leukemia Relapse Early following Transplant

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J Immunol. 2024 Oct 7:ji2300827. doi: 10.4049/jimmunol.2300827. Online ahead of print. ABSTRACT Identification of early immune signatures associated with acute myeloid leukemia (AML) relapse following hematopoietic stem cell transplant (HSCT) is critical for patient outcomes. We analyzed PBMCs from 58 patients with AML undergoing HSCT, focusing on T cell subsets and functional profiles. High-dimensional flow … Read more

IL-17: A Critical Cytokine for Defense against Oral Candidiasis

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J Immunol. 2024 Oct 15;213(8):1049-1051. doi: 10.4049/jimmunol.2400510. ABSTRACT This Pillars of Immunology article is a commentary on “Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis,” a pivotal article written by H. R. Conti, F. Shen, N. Nayyar, E. Stocum, J. N. Sun, M. J. Lindemann, A. W. Ho, … Read more

Immunometabolic Mechanisms of LANCL2 in CD4+ T Cells and Phagocytes Provide Protection from Systemic Lupus Erythematosus

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J Immunol. 2024 Oct 4:ji2400127. doi: 10.4049/jimmunol.2400127. Online ahead of print. ABSTRACT Lanthionine synthetase C-like 2 (LANCL2) is an immunoregulatory therapeutic target for autoimmune diseases. NIM-1324 is an investigational new drug aimed at addressing the unmet clinical needs of patients with systemic lupus erythematosus (SLE) by targeting the LANCL2 immunometabolic pathway. In R848 and bm12 … Read more

Microbe-binding Antibodies in the Female Genital Tract: Associations with the Vaginal Microbiome and Genital Immunology

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J Immunol. 2024 Sep 30:ji2400233. doi: 10.4049/jimmunol.2400233. Online ahead of print. ABSTRACT Bacteria-Ig interactions maintain homeostasis in the gut through the clearance of pathogenic bacteria and the development of immune tolerance to inflammatory bacteria; whether similar interactions modulate inflammation and bacterial colonization in the female genital tract is uncertain. In this study, we used a … Read more

Tim-3 Is Required for Regulatory T Cell-Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection

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J Immunol. 2024 Sep 30:ji2400119. doi: 10.4049/jimmunol.2400119. Online ahead of print. ABSTRACT Expression of T cell Ig and mucin domain-containing protein 3 (Tim-3) is upregulated on regulatory T cells (Tregs) during chronic viral infections. In several murine and human chronic infections, the expression of Tim-3 is associated with poor control of viral burden and impaired … Read more

Integrins α5β1 and αvβ3 Differentially Participate in the Recruitment and Reprogramming of Tumor-associated Macrophages in the In Vitro and In Vivo Models of Breast Tumor

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J Immunol. 2024 Sep 27:ji2400180. doi: 10.4049/jimmunol.2400180. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) drive the protumorigenic responses and facilitate tumor progression via matrix remodeling, angiogenesis, and immunosuppression by interacting with extracellular matrix proteins via integrins. However, the expression dynamics of integrin and its correlation with TAM functional programming in the tumors remain unexplored. … Read more

Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesis

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J Immunol. 2024 Sep 25:ji2400292. doi: 10.4049/jimmunol.2400292. Online ahead of print. ABSTRACT Vitamin D status, the vitamin D receptor (VDR), and the ability to produce active vitamin D [1,25(OH)2D, regulated by Cyp27b1] regulate fetal and adult hematopoiesis. Transgenic reporter mice that express the tdTomato RFP as an indication of Vdr expression were used to identify … Read more

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