The Journal of Immunology

J Immunol. 2025 Jul 3:vkaf136. doi: 10.1093/jimmun/vkaf136. Online ahead of print. ABSTRACT Tissue stromal cells are composed of numerous cell types with phenotypical and functional heterogeneity. Apart from providing structural support, they are emerging as key orchestrators of both activation and repression of immune responses in tissue microenvironment. The underlying mechanisms by which stromal cells … Read more

J Immunol. 2025 Jul 3:vkaf147. doi: 10.1093/jimmun/vkaf147. Online ahead of print. ABSTRACT Type 2 memory B cells (mBC2), identified in mice as IgG1+CD23+IL-4Rα+CD38+ B cells, which require IL-4 for genesis, are precursors for IgE plasma cells (PC) and considered key in allergy. While IL-21 is critical for normal mBC differentiation, its involvement in mBC2 formation … Read more

J Immunol. 2025 Jul 3:vkaf133. doi: 10.1093/jimmun/vkaf133. Online ahead of print. ABSTRACT Borrelia burgdorferi (or Borreliella burgdorferi), the extracellular spirochete responsible for Lyme disease, elicits a type I interferon (IFN-I) response critical for the development of Lyme arthritis. However, the specific pathogen-associated molecular pattern (PAMP) driving this response remains unidentified. Previous studies have reported that … Read more

J Immunol. 2025 Jul 1:vkaf135. doi: 10.1093/jimmun/vkaf135. Online ahead of print. ABSTRACT Macrophages, the central mediators of innate immune responses, can adapt and build nonspecific memory, also known as innate immune memory or trained immunity. Training of macrophages occurs through epigenetic changes and metabolic rewiring, which fuels macrophage responsiveness. In addition to training in response … Read more

J Immunol. 2025 Jun 28:vkaf125. doi: 10.1093/jimmun/vkaf125. Online ahead of print. ABSTRACT T cells are the most important cytotoxic cells involved in antitumor immune responses. After recognizing the major histocompatibility complex (MHC)-peptide complex, cytokines including interferon-γ (IFN-γ) are released to kill tumor cells. However, IFN-γ can also induce tumor cells to express PD-L1. This molecule … Read more

J Immunol. 2025 Mar 1;214(3):472-488. doi: 10.1093/jimmun/vkae060. ABSTRACT The Rels, a class of nuclear factor κB (NF-κB) complexes, regulate diverse physiological processes by modulating the transcription of effector genes. IκBs are the critical proteins that inhibit NF-κB nuclear translocation, thereby disrupting NF-κB-mediated signaling pathways. Despite this, the precise role and underlying molecular mechanisms of Rel … Read more

J Immunol. 2025 Jun 30:vkaf139. doi: 10.1093/jimmun/vkaf139. Online ahead of print. ABSTRACT Neoantigen-specific T cells play a major role in cancer immunotherapy. Mutated proteins derived from non-synonymous mutations in tumor genomic DNA are the major source of neoantigens. It is conceivable that non-synonymous mutations found in tumor mitochondrial DNA (mtDNA) can also generate neoantigens that … Read more

J Immunol. 2025 Jun 30:vkaf130. doi: 10.1093/jimmun/vkaf130. Online ahead of print. ABSTRACT Prostaglandin I2 (PGI2) is a lipid mediator known to inhibit T helper 2 (Th2) immune responses and allergic inflammation, but its role in regulating Th2 cell metabolism remains underexplored. Using the Seahorse assay, we evaluated the effects of PGI2 signaling on Th2 cell … Read more

J Immunol. 2025 Jun 28:vkaf137. doi: 10.1093/jimmun/vkaf137. Online ahead of print. NO ABSTRACT PMID:40587419 | DOI:10.1093/jimmun/vkaf137

J Immunol. 2025 Jun 24:vkaf059. doi: 10.1093/jimmun/vkaf059. Online ahead of print. ABSTRACT Plasma cell survival is influenced by various factors, including soluble mediators, intrinsic and extrinsic signals as well as adhesion molecules defining the bone marrow microenvironment. The role of their induction, turnover and competition dynamics among different antigen-specific bone marrow plasma cell subsets is … Read more