The Journal of Immunology

MHC II-restricted presentation of soluble antigen by naïve B cells is impaired upon engagement with membrane-associated antigen: A potential mechanism to mitigate autoreactivity

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J Immunol. 2025 Jun 23:vkaf129. doi: 10.1093/jimmun/vkaf129. Online ahead of print. ABSTRACT T cell tolerance to self can prevent self-reactive B cells from mounting effective autoimmune responses by limiting their available help. However, tolerance may be compromised during infection if small amounts of soluble cross-reactive pathogen antigens containing functional T cell epitopes are released for … Read more

G9a controls plasma cell differentiation through FOXO1 and ETS1 binding site regulatory networks

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J Immunol. 2025 Jun 23:vkaf127. doi: 10.1093/jimmun/vkaf127. Online ahead of print. ABSTRACT B cell differentiation is tightly regulated through coordinated changes in metabolism, division, expression of transcription factors, and epigenetic programming mediated by histone modifying enzymes. Here, we examined the role of an epigenetic writer, the histone H3K9 mono and dimethyltransferase G9a, in B cell … Read more

Cytokine and metabolite networks shape T cell residency and functionality at the term human maternal-fetal interface

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J Immunol. 2025 Jun 23:vkaf093. doi: 10.1093/jimmun/vkaf093. Online ahead of print. ABSTRACT Placentation presents immune conflict between mother and fetus, yet in normal pregnancy maternal immunity against infection is maintained without expense to fetal tolerance. This is believed to result from adaptations at the maternal-fetal interface (MFI), which affect T cell programming, but the identities … Read more

LAG3-MHCII interaction induces a tight cell-cell interface at the immunological synapse

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J Immunol. 2025 Jun 26:vkaf120. doi: 10.1093/jimmun/vkaf120. Online ahead of print. ABSTRACT Lymphocyte activation gene 3 (LAG3), an immune checkpoint, inhibits T cell function by binding to major histocompatibility complex class II (MHCII). Although LAG3 holds significant therapeutic potential for cancer immunotherapy, the molecular mechanisms underlying LAG3-mediated immunosuppression remain poorly characterized. Here, using a reconstituted … Read more

The role of VISTA engagement in limiting neutrophil-mediated inflammation

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J Immunol. 2025 Jun 26:vkaf132. doi: 10.1093/jimmun/vkaf132. Online ahead of print. ABSTRACT A growing body of evidence suggests that the immune checkpoint inhibitory receptor VISTA plays a central role in the regulation of innate immunity in the settings of inflammatory diseases and cancer. Neutrophils are among the cells that have the highest membrane density of … Read more

The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells

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J Immunol. 2025 Jun 16:vkaf124. doi: 10.1093/jimmun/vkaf124. Online ahead of print. ABSTRACT Marginal zone (MZ) B cells bridge innate and adaptive immunity by sensing bloodborne antigens and producing rapid antibody and cytokine responses. When unregulated, MZ B cells are associated with autoimmunity. CD55 is a membrane-bound complement regulator that interferes with complement activation and is … Read more

CD16a pairs form the basal molecular subunit for the NK-cell ADCC lytic synapse

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J Immunol. 2025 Jun 16:vkaf077. doi: 10.1093/jimmun/vkaf077. Online ahead of print. ABSTRACT NK cells utilize effector functions, including antibody-dependent cellular cytotoxicity (ADCC), for the clearance of viral infection and cellular malignancies. While antibody-induced clustering of FcγRIIIa (CD16a) is thought to drive ADCC, the molecular basis for this activity has not been fully described. We used … Read more

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