The Journal of Immunology

J Immunol. 2025 Jun 16:vkaf107. doi: 10.1093/jimmun/vkaf107. Online ahead of print. ABSTRACT CD8+ T cells are key effectors in immune control of Trypanosoma cruzi infection. Within C57BL/6 mice, the T. cruzi-specific CD8+ T cell response is largely comprised of T cells recognizing trans-sialidase (TS)- and mucin-encoded epitopes. Despite their immunodominance, these epitope-specific CD8+ T cells … Read more

J Immunol. 2025 Jun 16:vkaf117. doi: 10.1093/jimmun/vkaf117. Online ahead of print. ABSTRACT RTA-408, also known as Omaveloxolone, is an FDA-approved drug for treating Friedrich’s Ataxia, a neurological disorder. It is a triterpenoid compound that activates nuclear factor erythroid 2-related factor 2 (NRF2), a key regulator of cellular redox balance. In this study, we explored the … Read more

J Immunol. 2025 Jun 25:vkaf121. doi: 10.1093/jimmun/vkaf121. Online ahead of print. ABSTRACT We previously observed that circulating human neutrophils exposed to epithelial ovarian cancer (OC) ascites fluid supernatants (ASC) and malignant effusions from other tumors acquire T cell suppressor function. Collagen motifs ligate LAIR-1, an inhibitory SHP-1-dependent checkpoint broadly expressed on immune cells. We hypothesized … Read more

J Immunol. 2025 Jun 15:vkaf126. doi: 10.1093/jimmun/vkaf126. Online ahead of print. ABSTRACT Allergic asthma is a chronic inflammatory disease of the airways characterized by a type 2-high adaptive immune response towards common aeroantigens such as dust mite, pollen, and animal dander. Despite the advances made toward translation of various biologics into the clinic, the limited … Read more

J Immunol. 2025 Jun 14:vkaf157. doi: 10.1093/jimmun/vkaf157. Online ahead of print. NO ABSTRACT PMID:40515605 | DOI:10.1093/jimmun/vkaf157

J Immunol. 2025 Jun 13:vkaf161. doi: 10.1093/jimmun/vkaf161. Online ahead of print. NO ABSTRACT PMID:40514038 | DOI:10.1093/jimmun/vkaf161

J Immunol. 2025 Jun 12:vkaf100. doi: 10.1093/jimmun/vkaf100. Online ahead of print. ABSTRACT Modern antiretroviral therapy (ART) regimens have revolutionized the management of human immunodeficiency virus (HIV) and transformed it from a life-threatening disease to a manageable chronic condition. Despite the durable viral suppression associated with ART adherence, people with HIV (PWH) continue to experience chronic … Read more

J Immunol. 2025 Jun 12:vkaf111. doi: 10.1093/jimmun/vkaf111. Online ahead of print. ABSTRACT Colorectal cancer (CRC) progression is closely associated with the dynamic evolution of the tumor microenvironment. As a key component of the tumor microenvironment, tumor-associated neutrophils exhibit protumor properties and dynamically regulate malignant processes by secreting bioactive mediators that coordinate interactions among immune cells. … Read more

J Immunol. 2025 Jun 11:vkaf110. doi: 10.1093/jimmun/vkaf110. Online ahead of print. ABSTRACT Neutrophils are immune cells specialized in producing large amounts of reactive oxygen species (ROS) to kill microbes. However, the mechanisms by which these cells regulate the balance of different ROS species and mitigate oxidative stress remain unclear. Here, we demonstrate that superoxide dismutase … Read more

J Immunol. 2025 Jun 10:vkaf096. doi: 10.1093/jimmun/vkaf096. Online ahead of print. ABSTRACT Disease relapse is a major cause of death in acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The characterization of novel functional T-cell subtypes is critical for predicting clinical responses as well as developing strategies for immunotherapy in leukemia. … Read more