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J Immunol. 2024 Oct 15;213(8):1047. doi: 10.4049/jimmunol.2490014. NO ABSTRACT PMID:39374467 | DOI:10.4049/jimmunol.2490014
The Journal of Immunology
Immunometabolic Mechanisms of LANCL2 in CD4+ T Cells and Phagocytes Provide Protection from Systemic Lupus Erythematosus
J Immunol. 2024 Oct 4:ji2400127. doi: 10.4049/jimmunol.2400127. Online ahead of print. ABSTRACT Lanthionine synthetase C-like 2 (LANCL2) is an immunoregulatory therapeutic target for autoimmune diseases. NIM-1324 is an investigational new drug aimed at addressing the unmet clinical needs of patients with systemic lupus erythematosus (SLE) by targeting the LANCL2 immunometabolic pathway. In R848 and bm12 … Read more
Microbe-binding Antibodies in the Female Genital Tract: Associations with the Vaginal Microbiome and Genital Immunology
J Immunol. 2024 Sep 30:ji2400233. doi: 10.4049/jimmunol.2400233. Online ahead of print. ABSTRACT Bacteria-Ig interactions maintain homeostasis in the gut through the clearance of pathogenic bacteria and the development of immune tolerance to inflammatory bacteria; whether similar interactions modulate inflammation and bacterial colonization in the female genital tract is uncertain. In this study, we used a … Read more
Tim-3 Is Required for Regulatory T Cell-Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection
J Immunol. 2024 Sep 30:ji2400119. doi: 10.4049/jimmunol.2400119. Online ahead of print. ABSTRACT Expression of T cell Ig and mucin domain-containing protein 3 (Tim-3) is upregulated on regulatory T cells (Tregs) during chronic viral infections. In several murine and human chronic infections, the expression of Tim-3 is associated with poor control of viral burden and impaired … Read more
Integrins α5β1 and αvβ3 Differentially Participate in the Recruitment and Reprogramming of Tumor-associated Macrophages in the In Vitro and In Vivo Models of Breast Tumor
J Immunol. 2024 Sep 27:ji2400180. doi: 10.4049/jimmunol.2400180. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) drive the protumorigenic responses and facilitate tumor progression via matrix remodeling, angiogenesis, and immunosuppression by interacting with extracellular matrix proteins via integrins. However, the expression dynamics of integrin and its correlation with TAM functional programming in the tumors remain unexplored. … Read more
Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesis
J Immunol. 2024 Sep 25:ji2400292. doi: 10.4049/jimmunol.2400292. Online ahead of print. ABSTRACT Vitamin D status, the vitamin D receptor (VDR), and the ability to produce active vitamin D [1,25(OH)2D, regulated by Cyp27b1] regulate fetal and adult hematopoiesis. Transgenic reporter mice that express the tdTomato RFP as an indication of Vdr expression were used to identify … Read more
The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migration
J Immunol. 2024 Sep 25:ji2400228. doi: 10.4049/jimmunol.2400228. Online ahead of print. ABSTRACT G protein-coupled receptors (GPCRs) represent the largest family of surface receptors and are responsible for key physiological functions, including cell growth, neurotransmission, hormone release, and cell migration. The GPCR 56 (GPR56), encoded by ADGRG1, is an adhesion GPCR found on diverse cell types, … Read more
Intravenous Bacillus Calmette-Guérin (BCG) Induces a More Potent Airway and Lung Immune Response than Intradermal BCG in Simian Immunodeficiency Virus-infected Macaques
J Immunol. 2024 Sep 23:ji2400417. doi: 10.4049/jimmunol.2400417. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the leading causes of death due to an infectious agent. Coinfection with HIV exacerbates M. tuberculosis infection outcomes in people living with HIV. Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, is effective in … Read more
MARCH8 Mediates K27-Linked Polyubiquitination of IL-7 Receptor α to Negatively Regulate IL-7-Triggered T Cell Homeostasis
J Immunol. 2024 Sep 23:ji2400253. doi: 10.4049/jimmunol.2400253. Online ahead of print. ABSTRACT IL-7 is a cytokine produced by stromal cells, which binds to IL-7Rα and plays an important role for homeostasis of T lymphocytes. Excessive activities of IL-7-triggered signaling pathways causes autoimmune diseases. How IL-7-triggered signaling and immune effects are regulated is not fully understood. … Read more
Type I IFN Induces TCR-dependent and -independent Antimicrobial Responses in γδ Intraepithelial Lymphocytes
J Immunol. 2024 Sep 23:ji2400138. doi: 10.4049/jimmunol.2400138. Online ahead of print. ABSTRACT Intraepithelial lymphocytes (IELs) expressing the TCRγδ survey the intestinal epithelium to limit the invasion of microbial pathogens. The production of type I IFN is a central component of an antiviral immune response, yet how these proinflammatory cytokines contribute to γδ IEL effector function … Read more