The Journal of Immunology

J Immunol. 2024 Sep 20:ji2400196. doi: 10.4049/jimmunol.2400196. Online ahead of print. ABSTRACT Pre-eclampsia (PE) affects 5-8% of pregnancies and has detrimental effects on maternal-fetal health. PE is characterized by de novo hypertension after 20 wk of gestation and end-organ damage. Systemic inflammatory imbalance has been associated with PE, but its contribution to the pathology is … Read more

J Immunol. 2024 Sep 20:ji2400331. doi: 10.4049/jimmunol.2400331. Online ahead of print. ABSTRACT Expression of IL-15 on the surface of human graft endothelial cells (ECs) bound to the IL-15Rα subunit can increase the activation of CTLs, potentiating allograft rejection. Our previous work showed that surface expression of this protein complex could be induced by alloantibody-mediated complement … Read more

J Immunol. 2024 Sep 20:ji2400146. doi: 10.4049/jimmunol.2400146. Online ahead of print. ABSTRACT Alemtuzumab induction with belatacept/rapamycin-based maintenance immunotherapy (ABR) prevents kidney allograft rejection and specifically limits early costimulation blockade-resistant rejection (CoBRR). To evaluate the mechanisms by which this regimen alters CoBRR, we characterized the phenotype and functional response of preexisting memory cells to allogeneic endothelial … Read more

J Immunol. 2024 Sep 18:ji2400035. doi: 10.4049/jimmunol.2400035. Online ahead of print. ABSTRACT Innate immune responses such as phagocytosis are critically linked to the generation of adaptive immune responses against the neoantigens in cancer and the efferocytosis that is essential for homeostasis in diseases characterized by lung injury, inflammation, and remodeling as in chronic obstructive pulmonary … Read more