The Journal of Immunology

Gene-specific regulation of inflammation via TLR-induced chromatin modifications

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J Immunol. 2025 Jun 9:vkaf115. doi: 10.1093/jimmun/vkaf115. Online ahead of print. ABSTRACT This Pillars of Immunology article revisits the landmark 2007 study by Foster, Hargreaves, and Medzhitov-the first to uncover the mechanistic basis of memory in the innate immune system. This pivotal study marks a fundamental shift in our understanding of innate immunity, revealing an … Read more

Cutting edge: Extrinsic and intrinsic sex effects differentially regulate pulmonary ILC2 numbers, phenotype, and function

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J Immunol. 2025 Jun 9:vkaf114. doi: 10.1093/jimmun/vkaf114. Online ahead of print. ABSTRACT Pulmonary type 2 innate lymphocytes (ILC2s) show sex dimorphism in numbers, phenotype, and function. We used a novel strategy of competitive, mixed male-female donor bone marrow chimeras to determine if sex differences in murine ILC2s result from extrinsic factors in the recipient environment … Read more

Effect of statins on IL-10 signaling and production by chronic lymphocytic leukemia cells

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J Immunol. 2025 Jun 2:vkaf103. doi: 10.1093/jimmun/vkaf103. Online ahead of print. ABSTRACT The cytokine-signaling inhibitor ruxolitinib causes disease flares of chronic lymphocytic leukemia (CLL). This tumor-promoting activity correlates with its ability to inhibit interleukin (IL)-10 production by CLL B cells that have been activated with IL-2 and the Toll-like receptor 7 (TLR7) agonist resiquimod (called … Read more

Chemokine (C-X-C motif) ligand 11 is a crucial antiviral modulator that affects viral replication, the IFN-γ response, and T-cell functions during respiratory syncytial virus infection

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J Immunol. 2025 May 30:vkaf098. doi: 10.1093/jimmun/vkaf098. Online ahead of print. ABSTRACT Respiratory syncytial virus (RSV) is the leading cause of childhood respiratory infections worldwide. However, no vaccine is available for children, and treatment options are limited. Identification of host factors pivotal to viral replication or immune-inflammatory regulation may inform the development of novel therapies, … Read more

Mallard ILF2 negatively regulates type I IFN production through autophagy-lysosome-dependent degradation of IRF7

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J Immunol. 2025 May 30:vkaf118. doi: 10.1093/jimmun/vkaf118. Online ahead of print. ABSTRACT Interleukin enhancer-binding factor 2 (ILF2) has been reported to act as either a positive or negative regulator of viral infection by directly affecting viral RNA replication. In this study, mallard ILF2 was found to impair type I IFN production, thereby facilitating the replication … Read more

Defining key parameters of therapeutic activity using mouse cancer neoepitopes

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J Immunol. 2025 May 30:vkaf090. doi: 10.1093/jimmun/vkaf090. Online ahead of print. ABSTRACT Cancer neoepitopes have emerged as strong candidates as cancer vaccines. Mouse models of cancer neoepitopes often test their activity in models of prophylaxis, while the human setting is always in therapy of preexisting disease. We have previously identified 7 MHC I-presented cancer neoepitopes … Read more

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