J Immunol. 2025 May 1;214(5):889-902. doi: 10.1093/jimmun/vkae036. ABSTRACT The immune system has long been recognized for its critical role in the elimination of pathogens and the development of autoimmune diseases, but recent evidence demonstrates that it also contributes to noncommunicable diseases associated with biological aging processes, such as cancer, cardiovascular disease, neurodegeneration, and frailty. This … Read more
J Immunol. 2025 May 28:vkaf069. doi: 10.1093/jimmun/vkaf069. Online ahead of print. ABSTRACT Psoriasis is a chronic inflammatory skin disorder characterized by aberrant keratinocyte proliferation and immune cell infiltration with upregulation of inflammatory cytokines. Here, we examined the contribution of HCAR2 encoding for the short-chain fatty acid receptor GPR109A. Human and mouse RNA sequencing public datasets … Read more
J Immunol. 2025 Feb 26:vkaf081. doi: 10.1093/jimmun/vkaf081. Online ahead of print. ABSTRACT Fish lack organized mucosa-associated lymphoid tissues as found in birds and mammals. However, a distinct aggregation of lymphoid cells, the interbranchial lymphoid tissue (ILT), was identified in the gills of the Atlantic salmon (Salmo salar) in 2008. Since then, additional structures of similar … Read more
J Immunol. 2025 Feb 26:vkaf109. doi: 10.1093/jimmun/vkaf109. Online ahead of print. ABSTRACT The inhibitory Fc gamma receptor IIB (FcγRIIB) is a critical determinant of humoral immunity. By providing feedback inhibition, through inhibitory signalling or competition for antibody Fc engagement, it counterbalances and contextualises cellular responses to signals emanating from co-ligated activating receptors, such as the … Read more
J Immunol. 2025 May 27:vkaf050. doi: 10.1093/jimmun/vkaf050. Online ahead of print. ABSTRACT Bovine leukemia virus (BLV) causes enzootic bovine leukosis (EBL), a B-cell lymphoma in cattle. Previous studies have demonstrated that T cells of BLV-infected cattle show increased expression of immune checkpoint molecules, including programmed death-1 (PD-1), lymphocyte-activation gene-3 (LAG-3), cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), and … Read more
J Immunol. 2025 Feb 27:vkaf104. doi: 10.1093/jimmun/vkaf104. Online ahead of print. ABSTRACT Strain 68-1 rhesus CMV (RhCMV) vectors induce immune responses that mediate early, complete replication arrest of SIV infection in ∼60% of vaccinated rhesus macaques (RMs). This unique efficacy depends on the ability of these vectors to elicit effector memory (EM)-biased CD8+ T cells … Read more
J Immunol. 2025 May 25:vkaf106. doi: 10.1093/jimmun/vkaf106. Online ahead of print. NO ABSTRACT PMID:40414619 | DOI:10.1093/jimmun/vkaf106
J Immunol. 2025 May 25:vkaf073. doi: 10.1093/jimmun/vkaf073. Online ahead of print. ABSTRACT The mechanisms through which heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) contributes to innate immune gene regulation are poorly understood. To fill this gap, we generated a myeloid lineage-specific HNRNPA2B1-conditional mouse using LysMCre. In an endotoxic shock model, HNRNPA2B1-deficient mice exhibit dampened expression of inflammatory … Read more
J Immunol. 2025 May 23:vkaf102. doi: 10.1093/jimmun/vkaf102. Online ahead of print. ABSTRACT This study investigates the diagnostic potential of matrix metalloproteinase-9 (MMP-9), IL-8, and myeloperoxidase (MPO) in bronchoalveolar lavage fluid (BALF) as combined biomarkers for post-infectious bronchiolitis obliterans (PIBO) in children. BALF samples from children with PIBO were analyzed using ELISA to quantify MMP-9, IL-8, … Read more
J Immunol. 2025 May 22:vkaf101. doi: 10.1093/jimmun/vkaf101. Online ahead of print. ABSTRACT Higher circulating SARS-CoV-2 IgG titers correlate with SARS-CoV-2 ex vivo viral neutralization, but how well this translates to clinical protection in the real-world setting is unclear. In a prospective cohort study, we enrolled 44 SARS-CoV-2 negative, confirmed SARS-CoV-2 close contacts. Receptor-binding domain (RBD) … Read more
