The Journal of Immunology

J Immunol. 2025 May 22:vkaf086. doi: 10.1093/jimmun/vkaf086. Online ahead of print. ABSTRACT Memory T helper (Th) cells, generated in response to immunogenic challenges, are crucial in orchestrating adaptive immune responses. Acetylcholine (ACh), a key neurotransmitter of the parasympathetic nervous system, modulates immune function via muscarinic ACh receptors (mAChRs). This study investigates the role of mAChRs, … Read more

J Immunol. 2025 May 23:vkaf080. doi: 10.1093/jimmun/vkaf080. Online ahead of print. ABSTRACT Cancer immunotherapeutic CpG oligodeoxynucleotide (ODN) is an agonist for TLR9 and a potent inducer of inflammatory cytokines and type I interferon. Clinical trials of CpG ODNs highlight the urgent need for effective TLR9 agonist CpG ODNs in humans. Here, we developed a highly … Read more

J Immunol. 2025 May 21:vkaf092. doi: 10.1093/jimmun/vkaf092. Online ahead of print. ABSTRACT Influenza A(H3N2) viruses are currently evolving faster than any other subtype of seasonal influenza. As a result, vaccine efficacy can vary widely from one year to the next, and the wild-type antigens in the seasonal vaccine need to be updated frequently to stay … Read more

J Immunol. 2025 May 20:vkaf108. doi: 10.1093/jimmun/vkaf108. Online ahead of print. NO ABSTRACT PMID:40393776 | DOI:10.1093/jimmun/vkaf108

J Immunol. 2025 May 20:vkaf089. doi: 10.1093/jimmun/vkaf089. Online ahead of print. ABSTRACT Activation of the type I interferon (IFN-I) signaling pathway is crucial for protecting host cells against viral infections. IFN-I production requires the transcription factors IFN regulatory factor 3 (IRF3) and IRF7, and its regulation must be finely tuned to both combat infection effectively … Read more

J Immunol. 2025 May 17:vkaf099. doi: 10.1093/jimmun/vkaf099. Online ahead of print. ABSTRACT We discovered a protective role of G protein-coupled receptor 3 (GPR3) in a mouse model of T cell-mediated autoimmune uveitis. GPR3 is an orphan receptor that maintains Gs-coupling and cyclic AMP production without an exogenous ligand. Consequently, GPR3 deficient (GPR3KO) mice were more … Read more

J Immunol. 2025 May 17:vkaf095. doi: 10.1093/jimmun/vkaf095. Online ahead of print. ABSTRACT Hepatitis B virus (HBV) infection remains a significant global health challenge, characterized by chronic liver inflammation and compromised antiviral immunity. The outcome of HBV infection and associated liver pathogenesis is influenced mainly by the host innate immune and inflammatory responses. Characterizing the mechanisms … Read more

J Immunol. 2025 May 17:vkaf105. doi: 10.1093/jimmun/vkaf105. Online ahead of print. ABSTRACT Immunological memory is a hallmark of the adaptive immune system. However, considerable evidence indicates that the natural killer (NK) cell subset of innate lymphoid cells also mediates specific memory responses to diverse antigens, including peptides. Even though the existence of NK cell memory … Read more

J Immunol. 2025 May 16:vkaf058. doi: 10.1093/jimmun/vkaf058. Online ahead of print. ABSTRACT Toll-interacting protein (Tollip) is an intracellular adaptor protein with diverse functions including regulation of autophagy of mitochondria-mitophagy. Tollip deficiency promotes viral infection, but whether mitophagy is involved remains unclear. We sought to determine if mitophagy and associated signaling such as mitochondrial DNA (mtDNA) … Read more

J Immunol. 2025 May 15:vkaf049. doi: 10.1093/jimmun/vkaf049. Online ahead of print. ABSTRACT Atopic dermatitis (AD) and alopecia areata are highly prevalent inflammatory skin/hair conditions. While previously not fully understood and limited in treatment options, AD is currently undergoing a therapeutic revolution. Our increased understanding of the underlying immunologic and barrier dysregulations and disease heterogeneity across … Read more