J Immunol. 2025 May 15:vkaf091. doi: 10.1093/jimmun/vkaf091. Online ahead of print. ABSTRACT Secondary lymphoid organs (SLOs) provide a structured environment to facilitate interactions between low frequency antigen-specific B and T cells as well as cognate antigen displayed by antigen presenting cells (APCs), resulting in the initiation of effective adaptive immune responses. The spleen is the … Read more
J Immunol. 2025 May 15:vkaf087. doi: 10.1093/jimmun/vkaf087. Online ahead of print. ABSTRACT Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex heterogeneous multiorgan disease that can have severe impact on individuals’ quality of life. Diagnosis of ME/CFS is based on symptom presentation, and a significant goal for the field is to establish meaningful subtypes. The heterogeneity … Read more
J Immunol. 2025 May 15:vkaf084. doi: 10.1093/jimmun/vkaf084. Online ahead of print. ABSTRACT Genetic modification of T cells to express chimeric antigen receptors (CAR, CAR-T cells) enable them to recognize the specific antigen on tumor surface and then eliminate the tumor. T lymphocyte ion channels such as Kv1.3, KCa3.1 and CRAC influence T cell activation and … Read more
J Immunol. 2025 May 14:vkaf076. doi: 10.1093/jimmun/vkaf076. Online ahead of print. ABSTRACT Human metapneumovirus (HMPV) is a leading cause of respiratory tract infection in pediatric, elderly, and immunocompromised populations. Clearance of HMPV relies primarily on the destruction of infected cells by cytotoxic CD8+ T cells. However, signals provided by CD4+ helper T cells significantly impact … Read more
J Immunol. 2025 May 13:vkaf056. doi: 10.1093/jimmun/vkaf056. Online ahead of print. ABSTRACT Leprosy is a neglected chronic infectious disease caused by Mycobacterium leprae or M. lepromatosis, representing a public health concern in several low-income countries. In Brazil, most patients develop lepromatous leprosy, a clinical form characterized by poor bacillary control due to T helper 2 … Read more
J Immunol. 2025 May 13:vkaf064. doi: 10.1093/jimmun/vkaf064. Online ahead of print. ABSTRACT A balanced IFN response, tightly regulated at multiple levels, is essential for host defense against viral infection. Tripartite motif-containing (TRIM) proteins are a large group of E3 ubiquitin ligases, and have been shown to be involved in the regulation of IFN response. However, … Read more
J Immunol. 2025 May 13:vkaf083. doi: 10.1093/jimmun/vkaf083. Online ahead of print. ABSTRACT TCRγδ+ T cells are a major lymphocyte population of chickens, but their response or contribution to immunity against avian influenza virus (AIV) remains unknown. Here, we report an increase in the proportion and activation state of TCRγδ+CD8α+ T cells in the PBMCs of … Read more
J Immunol. 2025 May 12:vkaf113. doi: 10.1093/jimmun/vkaf113. Online ahead of print. NO ABSTRACT PMID:40356078 | DOI:10.1093/jimmun/vkaf113
J Immunol. 2025 May 12:vkaf078. doi: 10.1093/jimmun/vkaf078. Online ahead of print. ABSTRACT Alcohol use disorder increases sepsis mortality. Acute ethanol exposure impairs pathogen clearance in the macrophages via dampened glycolysis and phagocytosis, exaggerates oxidative stress, and regulates the function of the hypoxia-regulating factor 1α (HIF-1α), a master regulator of glycolysis. Decreased expression of the platelet … Read more
J Immunol. 2025 May 12:vkaf065. doi: 10.1093/jimmun/vkaf065. Online ahead of print. ABSTRACT Factor H controls proximal complement activation, and its dysfunction leads to diseases that often manifest in the kidney. Structural and functional analyses have identified 4 distinct functional segments: an N-terminal regulatory unit, a cell binding unit, a segment with combined low-affinity C3b and … Read more
