J Immunol. 2025 Oct 28:vkaf285. doi: 10.1093/jimmun/vkaf285. Online ahead of print. ABSTRACT The β2-adrenergic receptor (β2AR) signaling suppresses the activation of key inflammatory genes in Toll-like receptor (TLR) stimulated macrophages, but Il1b transcription is activated by β2AR signaling. The β2ARs potently activate protein kinase A and CREB, but other signaling pathways can also be activated, … Read more

J Immunol. 2025 Oct 28:vkaf288. doi: 10.1093/jimmun/vkaf288. Online ahead of print. ABSTRACT The risk of developing melanoma increases with age. Although immune checkpoint blockade (ICB) therapy has shown considerable success, a significant portion of melanoma patients either fail to respond to ICB or eventually develop resistance. This leads to the urgent need for exploring novel … Read more

J Immunol. 2025 Oct 28:vkaf279. doi: 10.1093/jimmun/vkaf279. Online ahead of print. ABSTRACT Natural killer (NK) cells play essential roles in immunity, but their limited infiltration into solid tumors restricts their therapeutic potential. Here, we identify fibroblast activation protein (FAP), previously thought to be largely fibroblast-restricted, as a novel surface-expressed protease on human NK cells. Using … Read more

J Immunol. 2025 Oct 25:vkaf275. doi: 10.1093/jimmun/vkaf275. Online ahead of print. NO ABSTRACT PMID:41139928 | DOI:10.1093/jimmun/vkaf275

J Immunol. 2025 Oct 25:vkaf264. doi: 10.1093/jimmun/vkaf264. Online ahead of print. ABSTRACT The liver contains a diverse repertoire of leukocytes, with liver B cells representing a significant population of hepatic immune cells in both newborns and adults. Despite their importance, these cells remain largely unexplored. In this study, we comprehensively characterized liver B cells from … Read more

J Immunol. 2025 Oct 23:vkaf256. doi: 10.1093/jimmun/vkaf256. Online ahead of print. ABSTRACT Highly immunodeficient BRGSF mice have proven to be suitable for reconstitution with human cord blood cell-derived CD34+ hematopoietic stem cells, enabling the generation of human immune system (HIS) mice. Here, we employ a robust comparative approach utilizing human lung biopsies to characterize the … Read more

J Immunol. 2025 Oct 23:vkaf270. doi: 10.1093/jimmun/vkaf270. Online ahead of print. ABSTRACT Nucleoporin 93 (Nup93), a key component of the nuclear pore complex, is involved in various cellular processes, such as immune signaling pathway. In mammals, Nup93 positively regulates the RLR signaling pathway by targeting TBK1 and IRF3. However, the role of Nup93 in teleost … Read more

J Immunol. 2025 Oct 17:vkaf274. doi: 10.1093/jimmun/vkaf274. Online ahead of print. ABSTRACT Sarcoidosis is a granulomatous systemic inflammatory disease predominantly affecting the lungs. It shares histopathological, clinical, and immune features with tuberculosis (TB). There are currently no diagnostic tests to formally identify sarcoidosis; instead, there is a need first to rule out the presence of … Read more

J Immunol. 2025 Oct 16:vkaf281. doi: 10.1093/jimmun/vkaf281. Online ahead of print. ABSTRACT DDX3 and other DEAD-box RNA helicases regulate nuclear export, translation, splicing, and metabolism of RNA. Perturbation of Ddx3x on the mouse X-chromosome in all hematopoietic cells resulted in a loss of natural killer (NK) cells, yet whether DDX3X is important only in progenitors … Read more

J Immunol. 2025 Oct 16:vkaf278. doi: 10.1093/jimmun/vkaf278. Online ahead of print. ABSTRACT Eukaryotic elongation factor 2 kinase (eEF2K) is a stress-responsive regulator of protein synthesis implicated in melanoma progression, but its role in tumor immune evasion remains poorly defined. We investigated how eEF2K influences programmed death ligand 1 (PD-L1) expression through modulation of Cyclin D1. … Read more