Trends in Immunology

Trends Immunol. 2026 Mar 11:S1471-4906(26)00039-6. doi: 10.1016/j.it.2026.02.008. Online ahead of print. ABSTRACT The rapid development of allogeneic engineered therapeutic cells has intensified the challenge of host immune-mediated rejection. Advances in molecular immunology, genetic engineering, and induced pluripotent stem cell-based multigene editing have enabled the creation of ‘stealth’ allogeneic cells designed to evade immune detection while … Read more

Trends Immunol. 2026 Mar 11:S1471-4906(26)00038-4. doi: 10.1016/j.it.2026.02.007. Online ahead of print. ABSTRACT Li et al. described a tumor-derived neuroimmune mechanism that promotes clearance of established amyloid pathology in Alzheimer’s disease. secreted cystatin C activates TREM2-dependent microglial phagocytosis, reducing plaques and improving cognition. This work introduces a context-dependent neuroimmune-modulatory strategy that shifts Alzheimer’s therapy from broad … Read more

Trends Immunol. 2026 Mar 7:S1471-4906(26)00035-9. doi: 10.1016/j.it.2026.02.004. Online ahead of print. ABSTRACT CD8+ T cell migration is central to host defense, enabling clonal selection, tissue infiltration, and elimination of infected cells. While chemokines guide these cells by activating Rac for F-actin polymerization, recent studies reveal a complementary mechanism through Rho activation. This pathway relies on … Read more

Trends Immunol. 2026 Mar 5:S1471-4906(26)00017-7. doi: 10.1016/j.it.2026.02.002. Online ahead of print. ABSTRACT De Leeuw et al. conducted human observational and murine studies to establish the combined role of parental aeroallergen sensitization and early-life respiratory syncytial virus infection in asthma development. The findings reveal synergistic effects driving immunological, pathological, and physiological changes resembling asthma, advancing the … Read more

Trends Immunol. 2026 Mar 3:S1471-4906(25)00316-3. doi: 10.1016/j.it.2025.12.008. Online ahead of print. ABSTRACT Bile acids are cholesterol derivatives, generated by the coordinated intervention of human and bacterial genes, functioning as endogenous ligands for multiple transcription factors and receptors throughout the body. While only two primary bile acids are generated by the human liver, the intestinal microbiota … Read more

Trends Immunol. 2026 Mar 2:S1471-4906(26)00014-1. doi: 10.1016/j.it.2026.01.011. Online ahead of print. ABSTRACT During pregnancy, complex interactions of maternal immune cells and fetal extravillous trophoblasts (EVTs) orchestrate placentation, immune tolerance, and immune defense. This forum article highlights important discoveries and outstanding questions on how the activation of decidual natural killer and T cells, through recognition of … Read more

Trends Immunol. 2026 Feb 27:S1471-4906(26)00002-5. doi: 10.1016/j.it.2026.01.002. Online ahead of print. ABSTRACT Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation … Read more

Trends Immunol. 2026 Feb 26:S1471-4906(26)00010-4. doi: 10.1016/j.it.2026.01.007. Online ahead of print. ABSTRACT Lactation is increasingly recognized as an immune-regulated process. Immune cells shape mammary gland development, coordinate tissue remodeling, and aid in milk production with lasting consequences for maternal health. Here, we summarize recent advances on the roles and dynamics of T cells in the … Read more

Trends Immunol. 2026 Feb 6:S1471-4906(26)00013-X. doi: 10.1016/j.it.2026.01.010. Online ahead of print. ABSTRACT Dendritic cell (DC) maintenance and positioning are essential for their function in lymph nodes. Wu et al. identify gremlin1 (Grem1)+ fibroblastic reticular cells as critical source of niche-specific Fms-like tyrosine kinase 3 ligand (Flt3L) for conventional DC maintenance in health and disease, highlighting … Read more

Trends Immunol. 2026 Jan 8:S1471-4906(25)00315-1. doi: 10.1016/j.it.2025.12.007. Online ahead of print. ABSTRACT The brain is no longer viewed as immunologically isolated but as an organ surrounded by dynamic border compartments that coordinate surveillance, drainage, and communication with the periphery. Key interfaces – including the meninges, blood-brain barrier, choroid plexus (ChP), and skull bone marrow – … Read more