Trends in Immunology

Trends Immunol. 2026 Jun 16:S1471-4906(26)00105-5. doi: 10.1016/j.it.2026.05.001. Online ahead of print. ABSTRACT The epithelial, microbial, and immune components of the intestinal barrier coexist in harmony to prevent undesirable inflammatory outcomes and ensure homeostasis in the host. In this review, we outline molecular mechanisms by which T cells regulate intestinal homeostasis and how the ageing-associated dysfunction … Read more

Trends Immunol. 2026 Jun 15:S1471-4906(26)00156-0. doi: 10.1016/j.it.2026.06.004. Online ahead of print. ABSTRACT While androgen deprivation is widely used in urological oncology to restrain tumor growth and prevent T cell exhaustion, Lee et al. reveal a striking reversal in glioblastoma. In glioblastoma, androgen loss triggers microglial cytokines, activates the hypothalamic-pituitary-adrenal axis, and induces glucocorticoid-dependent T cell … Read more

Trends Immunol. 2026 Jun 13:S1471-4906(26)00133-X. doi: 10.1016/j.it.2026.05.008. Online ahead of print. NO ABSTRACT PMID:42285831 | DOI:10.1016/j.it.2026.05.008

Trends Immunol. 2026 Jun 12:S1471-4906(26)00134-1. doi: 10.1016/j.it.2026.05.009. Online ahead of print. NO ABSTRACT PMID:42285830 | DOI:10.1016/j.it.2026.05.009

Trends Immunol. 2026 Jun 12:S1471-4906(26)00135-3. doi: 10.1016/j.it.2026.05.010. Online ahead of print. NO ABSTRACT PMID:42285829 | DOI:10.1016/j.it.2026.05.010

Trends Immunol. 2026 Jun 10:S1471-4906(26)00130-4. doi: 10.1016/j.it.2026.05.005. Online ahead of print. ABSTRACT Bioelectric signaling may represent an emerging layer of macrophage communication. This forum discusses how membrane-potential dynamics, ion fluxes, and context-dependent intercellular coupling may coordinate macrophage responses within tissues, highlighting a potential new dimension of immune regulation with broad implications for tissue-level immunity. PMID:42270522 … Read more

Trends Immunol. 2026 Jun 9:S1471-4906(26)00129-8. doi: 10.1016/j.it.2026.05.004. Online ahead of print. ABSTRACT Immune-mediated inflammatory disorders, such as inflammatory bowel diseases, are characterized by chronic inflammation and damage to the intestinal barrier. Several of the current therapeutic strategies for inflammatory diseases attempt to decrease inflammation but cause side effects in a significant fraction of patients without … Read more

Trends Immunol. 2026 Jun 9:S1471-4906(26)00131-6. doi: 10.1016/j.it.2026.05.006. Online ahead of print. ABSTRACT Immunity and metabolism are deeply intertwined in maintaining homeostasis. With the recognition of cytosolic dsDNA sensing as an initiator of immune responses, its interface with metabolic rewiring has emerged as a key area of investigation. Focusing on the stimulator of interferon genes adaptor … Read more

Trends Immunol. 2026 Jun 9:S1471-4906(26)00132-8. doi: 10.1016/j.it.2026.05.007. Online ahead of print. ABSTRACT Pancreatic cancer is a deadly disease defined by an immunosuppressive microenvironment refractory to therapy. Kiemen et al. applied 3D histology, imaging mass cytometry, and spatially resolved DNA sequencing to human pancreata containing early precursors of the disease, revealing heterogeneous and mutation-specific inflammatory niches … Read more

Trends Immunol. 2026 Jun 9:S1471-4906(26)00128-6. doi: 10.1016/j.it.2026.05.003. Online ahead of print. ABSTRACT Tissue-resident macrophages exhibit remarkable plasticity, dynamically adapting to their local environment and adopting tissue-specific phenotypes that support organ homeostasis. The underlying identity-determining transcriptional programs are instructed by microenvironmental cues. Transforming growth factor-β (TGF-β), which has long been recognized for its role in immunosuppression, … Read more