Trends Immunol. 2026 Aug 19:S1471-4906(26)00193-6. doi: 10.1016/j.it.2026.07.014. Online ahead of print. ABSTRACT Maternal milk antibodies are garnering increasing interest. While IgA dominates the milk antibody literature, IgG is emerging as a critical source of protection for the hyporesponsive neonate against life-threatening infections and as an important factor in instructing developing immunity. In this forum article, … Read more
Trends Immunol. 2026 Aug 18:S1471-4906(26)00214-0. doi: 10.1016/j.it.2026.08.001. Online ahead of print. ABSTRACT Exercise reshapes host physiology and immunity, yet the mechanisms linking physical activity to disease protection remain incompletely defined. Emerging evidence indicates that exercise remodels the gut microbiome, producing compositional and metabolic adaptations that can regulate immune function. In this Review, we discuss how … Read more
Trends Immunol. 2026 Aug 18:S1471-4906(26)00192-4. doi: 10.1016/j.it.2026.07.013. Online ahead of print. ABSTRACT Mitochondrial complex II, succinate dehydrogenase (SDH), links the tricarboxylic acid cycle to the electron transport chain by oxidizing succinate to fumarate and reducing ubiquinone. This unusual position gives Complex II control over bioenergetics, redox state, succinate signaling, and chromatin regulation. In immune cells, … Read more
Trends Immunol. 2026 Aug 18:S1471-4906(26)00190-0. doi: 10.1016/j.it.2026.07.011. Online ahead of print. NO ABSTRACT PMID:42608258 | DOI:10.1016/j.it.2026.07.011
Trends Immunol. 2026 Aug 14:S1471-4906(26)00188-2. doi: 10.1016/j.it.2026.07.009. Online ahead of print. ABSTRACT A recent report by Fan et al. identifies trans-vaccenic acid, a maternal diet-derived lipid transferred through breast milk, as a key regulator of neonatal T-cell development. Beyond identifying a single bioactive metabolite, this study positions breast milk as a source of developmental signals … Read more
Trends Immunol. 2026 Aug 13:S1471-4906(26)00186-9. doi: 10.1016/j.it.2026.07.007. Online ahead of print. ABSTRACT Natural killer (NK) cells are effectors of innate antitumor immunity, yet their therapeutic potential in solid tumors remains largely unrealized. Breast cancer exemplifies this paradox: NK cells are present in circulation and detectable within tumors, but their cytotoxic activity is limited. Recent advances … Read more
Trends Immunol. 2026 Aug 7:S1471-4906(26)00185-7. doi: 10.1016/j.it.2026.07.006. Online ahead of print. ABSTRACT Immune surveillance of the central nervous system (CNS) is regulated by the brain barriers. Antigen presentation at the blood-brain barrier (BBB) has been proposed to promote antigen-specific T-cell entry into the CNS, largely based on in vitro studies. Recent in vivo and transcriptomic … Read more
Trends Immunol. 2026 Aug 5:S1471-4906(26)00183-3. doi: 10.1016/j.it.2026.07.004. Online ahead of print. ABSTRACT Emerging evidence now points to innate tissue immunity as a critical orchestrator of both local tissue adaptation and long-range hematopoietic reprogramming, including the amplification of emergency granulopoiesis through bone marrow progenitor remodeling. These findings position the intestine as an instructive niche capable of … Read more
Trends Immunol. 2026 Aug 1:S1471-4906(26)00184-5. doi: 10.1016/j.it.2026.07.005. Online ahead of print. NO ABSTRACT PMID:42542412 | DOI:10.1016/j.it.2026.07.005
Trends Immunol. 2026 Aug 1:S1471-4906(26)00187-0. doi: 10.1016/j.it.2026.07.008. Online ahead of print. ABSTRACT Spatial multi-omics of aging human lymph nodes by Fan and colleagues reveals that immunosenescence manifests as focal B cell coalescence into ‘SenSpots’ within germinal centers, where concerted epigenetic, transcriptional, proteomic, and metabolic reprogramming spatially orchestrates the decline of humoral immunity. PMID:42538165 | DOI:10.1016/j.it.2026.07.008
