Trends in Immunology

Trends Immunol. 2026 Mar 31:S1471-4906(26)00037-2. doi: 10.1016/j.it.2026.02.006. Online ahead of print. ABSTRACT THEMIS (thymocyte-expressed molecule involved in selection) is the founding member of a family of metazoan proteins distinguished by the presence of a novel structural element designated the cysteine-containing all-beta-in-THEMIS (CABIT) module. Several studies have confirmed a critical role for THEMIS in T cell … Read more

Trends Immunol. 2026 Mar 31:S1471-4906(26)00041-4. doi: 10.1016/j.it.2026.03.001. Online ahead of print. ABSTRACT Endothelial cells (ECs), which form the monolayer lining the vasculature, serve as critical gatekeepers of vascular homeostasis. They actively coordinate immune cell recruitment, adhesion, migration, and activation. Through tightly controlled expression and secretion of chemokines, cytokines, adhesion molecules, and immunomodulatory proteins, ECs locally … Read more

Trends Immunol. 2026 Mar 27:S1471-4906(26)00012-8. doi: 10.1016/j.it.2026.01.009. Online ahead of print. ABSTRACT Natural killer (NK) cells are innate lymphocytes uniquely equipped with stochastically expressed activating and inhibitory receptors that shape their cytotoxic potential. Although traditionally viewed as rapid and potent innate effectors against infected or transformed cells, we now appreciate that NK cells possess adaptive … Read more

Trends Immunol. 2026 Mar 28:S1471-4906(26)00063-3. doi: 10.1016/j.it.2026.03.004. Online ahead of print. ABSTRACT Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a large family of intracellular pattern recognition receptors primarily involved in innate immunity. Although canonical inflammasome-forming NLRs, such as NLRP3 and NLRC4, and microbial sensors, including NOD1 and NOD2, are well-characterized, the functions of many other … Read more

Trends Immunol. 2026 Mar 27:S1471-4906(26)00040-2. doi: 10.1016/j.it.2026.02.009. Online ahead of print. ABSTRACT The importance of γδ T cells in cancer, as defenders against tumorigenesis, was established more than 2 decades ago. Since that time, research using mouse models of cancer has brought to light a nonuniform view of tumor-associated γδ T cells by providing granularity … Read more

Trends Immunol. 2026 Mar 26:S1471-4906(26)00008-6. doi: 10.1016/j.it.2026.01.005. Online ahead of print. ABSTRACT Endometriosis is increasingly recognized as a systemic disorder involving complex interactions between nerves and immune cells, driving chronic pain and inflammation beyond the initial theories. Recent breakthroughs highlight aberrant sensory nerve growth and dysfunctional immune responses as key events in lesion development and … Read more

Trends Immunol. 2026 Mar 25:S1471-4906(26)00061-X. doi: 10.1016/j.it.2026.03.002. Online ahead of print. ABSTRACT Group 3 innate lymphoid cells (ILC3s) promote gastrointestinal health, dynamically interface with diet and microbes, and become impaired during chronic inflammation or metabolic syndrome. Torrico and colleagues uncover a key pathway rapidly disrupting ILC3 homeostasis in the intestines of humans and mice following … Read more

Trends Immunol. 2026 Mar 19:S1471-4906(26)00001-3. doi: 10.1016/j.it.2026.01.001. Online ahead of print. ABSTRACT Adjuvants are critical to improving the magnitude, breadth, functionality, and durability of vaccine immunogenicity. Despite advances in vaccinology, long-term immunity, variant cross-protection, and robust mucosal responses remain unmet goals. These challenges underscore the need for novel, safe, and effective adjuvants. This review explores … Read more

Trends Immunol. 2026 Mar 19:S1471-4906(26)00007-4. doi: 10.1016/j.it.2026.01.004. Online ahead of print. NO ABSTRACT PMID:41862359 | DOI:10.1016/j.it.2026.01.004

Trends Immunol. 2026 Mar;47(3):171-172. doi: 10.1016/j.it.2026.02.001. NO ABSTRACT PMID:41861783 | DOI:10.1016/j.it.2026.02.001