Trends in Immunology

Trends Immunol. 2024 Nov 12:S1471-4906(24)00248-5. doi: 10.1016/j.it.2024.10.002. Online ahead of print. ABSTRACT Peripheral immune cells play an important role in the pathology of Alzheimer’s disease (AD), impacting processes such as amyloid and tau protein aggregation, glial activation, neuronal integrity, and cognitive decline. Here, we examine cutting-edge strategies – encompassing animal and cellular models – used … Read more

Trends Immunol. 2024 Oct 22:S1471-4906(24)00218-7. doi: 10.1016/j.it.2024.09.010. Online ahead of print. ABSTRACT Brain metastasis poses formidable clinical challenges due to its intricate interactions with the brain’s unique immune environment, often resulting in poor prognoses. This review delves into systems immunology’s role in uncovering the dynamic interplay between metastatic cancer cells and brain immunity. Leveraging spatial … Read more

Trends Immunol. 2024 Oct 21:S1471-4906(24)00219-9. doi: 10.1016/j.it.2024.09.011. Online ahead of print. ABSTRACT The respiratory tract is exposed to infection from inhaled pathogens, including viruses, bacteria, and fungi. So far, a comprehensive assessment that integrates common and distinct aspects of the immune response along different areas of the respiratory tract has been lacking. Here, we discuss … Read more

Trends Immunol. 2024 Oct 21:S1471-4906(24)00220-5. doi: 10.1016/j.it.2024.09.012. Online ahead of print. ABSTRACT Immune cell fate decisions are regulated, at least in part, by nuclear architecture. Here, we outline how nuclear architecture instructs mammalian polymorphonuclear cell differentiation. We discuss how in neutrophils loop extrusion mechanisms regulate the expression of genes involved in phagocytosis and shape nuclear … Read more

Trends Immunol. 2024 Oct 17:S1471-4906(24)00221-7. doi: 10.1016/j.it.2024.09.013. Online ahead of print. ABSTRACT Cholesterol metabolites, particularly oxidized forms known as oxysterols, play crucial roles in modulating immune and metabolic processes across various tissues. Concentrations of local cholesterol and its metabolites influence tissue-specific immune responses by shaping the metabolic and spatial organization of immune cells in barrier … Read more

Trends Immunol. 2024 Oct 11:S1471-4906(24)00247-3. doi: 10.1016/j.it.2024.10.001. Online ahead of print. ABSTRACT Gao, Kim, and colleagues recently reported that clonal populations of CD4+ T cells could be detected in mice that underwent spinal cord injury (SCI). A subset of clones mediated enhanced motor recovery and suppressed inflammation. Further studies may point towards novel cell therapies … Read more

Trends Immunol. 2024 Oct 10:S1471-4906(24)00217-5. doi: 10.1016/j.it.2024.09.009. Online ahead of print. ABSTRACT The development of mammalian adaptive (i.e., B and T cell-mediated) immune responses is tightly controlled at transcriptional, epigenetic, and metabolic levels. Signals derived from the extracellular milieu are crucial regulators of adaptive immunity. Beyond the traditionally studied cytokines and chemokines, many other extracellular … Read more

Trends Immunol. 2024 Oct 1:S1471-4906(24)00188-1. doi: 10.1016/j.it.2024.08.002. Online ahead of print. ABSTRACT Reciprocal communication between the brain and the immune system is essential for maintaining lifelong brain function. This interaction is mediated, at least in part, by immune cells recruited from both the circulation and niches at the borders of the brain. Here, we describe … Read more

Trends Immunol. 2024 Sep 24:S1471-4906(24)00210-2. doi: 10.1016/j.it.2024.09.002. Online ahead of print. ABSTRACT Circulating immune cells contribute to the pathogenesis of Alzheimer’s disease (AD), but their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin (IL)-17+ neutrophils that inhibit neuroprotective microglia in female APOE4 carriers. Blockade of IL-17 signaling or APOE4 deletion … Read more

Trends Immunol. 2024 Sep 24:S1471-4906(24)00189-3. doi: 10.1016/j.it.2024.08.003. Online ahead of print. ABSTRACT Neural cells in our central nervous system (CNS) have long been thought to be mere targets of neuroinflammatory events in neurodegenerative diseases such as multiple sclerosis (MS) or Alzheimer’s disease. While glial populations such as microglia and astrocytes emerged as active responders and … Read more