Trends in Immunology

Trends Immunol. 2024 Sep 25:S1471-4906(24)00214-X. doi: 10.1016/j.it.2024.09.006. Online ahead of print. ABSTRACT Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts … Read more

Trends Immunol. 2024 Sep 25:S1471-4906(24)00213-8. doi: 10.1016/j.it.2024.09.005. Online ahead of print. ABSTRACT Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading … Read more

Trends Immunol. 2024 Sep 25:S1471-4906(24)00211-4. doi: 10.1016/j.it.2024.09.003. Online ahead of print. ABSTRACT Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate that the SARS-CoV-2 spike protein interacts with fibrinogen, promoting fibrin polymerization and its inflammatory activity. Targeting the inflammatory fibrin … Read more