Trends in Immunology

Trends Immunol. 2025 Apr 15:S1471-4906(25)00077-8. doi: 10.1016/j.it.2025.03.003. Online ahead of print. ABSTRACT The Molecular Mechanisms of Immune Cell Development and Function (MMICDF) meeting sponsored by the Federation of American Societies of Experimental Biology (FASEB) occupies a special niche because of its focus on the molecular mechanisms that underpin immunological processes. This biennial meeting with small … Read more

Trends Immunol. 2025 Apr 10:S1471-4906(25)00080-8. doi: 10.1016/j.it.2025.03.006. Online ahead of print. ABSTRACT Vaccination campaigns have reshaped infectious disease dynamics, exerting selective pressures on pathogens. While some are controlled, others persist via antigenic variation or reservoirs. This Science & Society explores the evolutionary and ecological impacts of vaccination, highlighting its role in pathogen adaptation and implications … Read more

Trends Immunol. 2025 Apr 11:S1471-4906(25)00058-4. doi: 10.1016/j.it.2025.02.015. Online ahead of print. ABSTRACT In the germinal center (GC), B cells undergo rounds of somatic hypermutation (SHM), proliferation, and positive selection to develop into high-affinity, long-lived plasma cells and memory B cells. It is well established that, upon activation, B cells significantly alter their metabolism, but until … Read more

Trends Immunol. 2025 Mar 31:S1471-4906(25)00059-6. doi: 10.1016/j.it.2025.03.001. Online ahead of print. ABSTRACT While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated macrophages (TAMs). Among these, interleukin (IL)-1β+ TAMs – cells with high levels of expression of inflammatory response and tissue … Read more

Trends Immunol. 2025 Mar 27:S1471-4906(25)00076-6. doi: 10.1016/j.it.2025.03.002. Online ahead of print. ABSTRACT The ongoing evolution of SARS-CoV-2 poses significant challenges to existing neutralizing antibodies and vaccines through immune escape mutations. By leveraging genomic surveillance and antibody deep mutational scanning (DMS) data, Raharinirina and colleagues developed a computational framework to elucidate region-specific SARS-CoV-2 variant dynamics and … Read more

Trends Immunol. 2025 Mar 24:S1471-4906(25)00057-2. doi: 10.1016/j.it.2025.02.014. Online ahead of print. ABSTRACT Cancer is increasingly prevalent worldwide, often coexisting with type 2 diabetes (T2D). Recent breakthroughs reveal the immune system’s pivotal role in eliminating tumors and how the metabolic environment, such as glucose availability, affects antitumor immunity. Diabetes is known to dysregulate both innate and … Read more

Trends Immunol. 2025 Mar 22:S1471-4906(25)00052-3. doi: 10.1016/j.it.2025.02.009. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the leading causes of death worldwide. TB pathogenesis is shaped by a complex interaction between the pathogen and host immune responses, particularly through mechanisms such as oxidative stress and ferroptosis; a form of … Read more

Trends Immunol. 2025 Mar 19:S1471-4906(25)00053-5. doi: 10.1016/j.it.2025.02.010. Online ahead of print. ABSTRACT Various mammalian CD8+ T cell subsets with regulatory properties are either formed through a thymus-dependent mechanism or induced under various experimental protocols and referred to as CD8+ regulatory T cells (Tregs). CD8+ Tregs maintain distinct functions in the presence of CD4+ Tregs. This … Read more

Trends Immunol. 2025 Mar 19:S1471-4906(25)00055-9. doi: 10.1016/j.it.2025.02.012. Online ahead of print. ABSTRACT The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary tool in our fight against respiratory infections. These immunotherapies can activate a wide spectrum of immunological mechanisms, … Read more

Trends Immunol. 2025 Mar 19:S1471-4906(25)00054-7. doi: 10.1016/j.it.2025.02.011. Online ahead of print. ABSTRACT Microglia, key orchestrators of the brain’s immune responses, play a pivotal role in the progression of Alzheimer’s disease (AD). Emerging human models, including stem cell-derived microglia and cerebral organoids, are transforming our understanding of microglial contributions to AD pathology. In this review, we … Read more