Trends in Immunology

Trends Immunol. 2026 Mar 26:S1471-4906(26)00008-6. doi: 10.1016/j.it.2026.01.005. Online ahead of print. ABSTRACT Endometriosis is increasingly recognized as a systemic disorder involving complex interactions between nerves and immune cells, driving chronic pain and inflammation beyond the initial theories. Recent breakthroughs highlight aberrant sensory nerve growth and dysfunctional immune responses as key events in lesion development and … Read more

Trends Immunol. 2026 Mar 25:S1471-4906(26)00061-X. doi: 10.1016/j.it.2026.03.002. Online ahead of print. ABSTRACT Group 3 innate lymphoid cells (ILC3s) promote gastrointestinal health, dynamically interface with diet and microbes, and become impaired during chronic inflammation or metabolic syndrome. Torrico and colleagues uncover a key pathway rapidly disrupting ILC3 homeostasis in the intestines of humans and mice following … Read more

Trends Immunol. 2026 Mar 19:S1471-4906(26)00001-3. doi: 10.1016/j.it.2026.01.001. Online ahead of print. ABSTRACT Adjuvants are critical to improving the magnitude, breadth, functionality, and durability of vaccine immunogenicity. Despite advances in vaccinology, long-term immunity, variant cross-protection, and robust mucosal responses remain unmet goals. These challenges underscore the need for novel, safe, and effective adjuvants. This review explores … Read more

Trends Immunol. 2026 Mar 19:S1471-4906(26)00007-4. doi: 10.1016/j.it.2026.01.004. Online ahead of print. NO ABSTRACT PMID:41862359 | DOI:10.1016/j.it.2026.01.004

Trends Immunol. 2026 Mar;47(3):171-172. doi: 10.1016/j.it.2026.02.001. NO ABSTRACT PMID:41861783 | DOI:10.1016/j.it.2026.02.001

Trends Immunol. 2026 Mar 18:S1471-4906(26)00006-2. doi: 10.1016/j.it.2026.01.003. Online ahead of print. ABSTRACT While artificial intelligence (AI) is transforming biological science, its full potential in immunology has yet to be realized due to limited data and the need for extensive experimental validation. This review provides a practical guide for experimental immunologists to actively contribute to AI … Read more

Trends Immunol. 2026 Mar 18:S1471-4906(26)00015-3. doi: 10.1016/j.it.2026.01.012. Online ahead of print. ABSTRACT Deciphering how mRNA vaccines generate humoral immunity could accelerate next-generation vaccine design. Castaño et al. reveal that mRNA-lipid nanoparticle vaccines employ a dual-adjuvant mechanism: nucleoside-modified mRNA triggers type I interferons to mature dendritic cells, while lipid nanoparticles induce a pro-T follicular helper cell … Read more

Trends Immunol. 2026 Mar 18:S1471-4906(26)00011-6. doi: 10.1016/j.it.2026.01.008. Online ahead of print. ABSTRACT Type 2 immunity protects against helminths and venoms, yet its dysregulation drives allergic diseases. Initiation occurs at barrier tissues, where epithelial cells detect perturbations and release alarmins, activating type 2 innate lymphoid cells and conditioning dendritic cells for T helper 2 priming. However, … Read more

Trends Immunol. 2026 Mar 17:S1471-4906(25)00317-5. doi: 10.1016/j.it.2025.12.009. Online ahead of print. ABSTRACT The immunological synapse (IS) formed between cytotoxic CD8+ T lymphocytes (CTLs) and tumor cells represents the critical interface where many immunotherapies act, including therapeutic antibodies and chimeric antigen receptor immunotherapy. However, detailed characterization of the CTL-tumor IS has remained limited, primarily due to … Read more

Trends Immunol. 2026 Mar 17:S1471-4906(26)00034-7. doi: 10.1016/j.it.2026.02.003. Online ahead of print. ABSTRACT Cheng et al.’s recent study identifies the Cullin3-RING E3 ubiquitin ligase complexes (CRL3) adaptor protein Kelch-like protein 6 (KLHL6) as a proteostasis regulator whose downregulation in chronically stimulated T cells leads to the accumulation of thymocyte selection-associated high mobility group box protein and … Read more