Trends in Immunology

Trends Immunol. 2026 Jun 23:S1471-4906(26)00138-9. doi: 10.1016/j.it.2026.06.001. Online ahead of print. ABSTRACT Growing evidence indicates that gut microbiota-derived metabolites are key regulators of immunometabolism in inflammatory bowel disease (IBD). Intestinal epithelial cells and immune cells exhibit profound metabolic alterations in IBD. Microbial metabolites act as intermediates in host-microbe communication, reshaping mitochondrial functions and cellular metabolic … Read more

Trends Immunol. 2026 Jun 19:S1471-4906(26)00139-0. doi: 10.1016/j.it.2026.06.002. Online ahead of print. ABSTRACT Inflammation is a metabolically intensive and tightly regulated process, driven primarily by innate immune cells. Cellular metabolism actively instructs immune signaling and cell fate decisions. Bioenergetic pathways, including glycolysis, mitochondrial respiration, and the tricarboxylic acid cycle, reshape cytokine production and regulate inflammatory cell … Read more

Trends Immunol. 2026 Jun 17:S1471-4906(26)00136-5. doi: 10.1016/j.it.2026.05.011. Online ahead of print. NO ABSTRACT PMID:42309886 | DOI:10.1016/j.it.2026.05.011

Trends Immunol. 2026 Jun 16:S1471-4906(26)00105-5. doi: 10.1016/j.it.2026.05.001. Online ahead of print. ABSTRACT The epithelial, microbial, and immune components of the intestinal barrier coexist in harmony to prevent undesirable inflammatory outcomes and ensure homeostasis in the host. In this review, we outline molecular mechanisms by which T cells regulate intestinal homeostasis and how the ageing-associated dysfunction … Read more

Trends Immunol. 2026 Jun 15:S1471-4906(26)00156-0. doi: 10.1016/j.it.2026.06.004. Online ahead of print. ABSTRACT While androgen deprivation is widely used in urological oncology to restrain tumor growth and prevent T cell exhaustion, Lee et al. reveal a striking reversal in glioblastoma. In glioblastoma, androgen loss triggers microglial cytokines, activates the hypothalamic-pituitary-adrenal axis, and induces glucocorticoid-dependent T cell … Read more

Trends Immunol. 2026 Jun 13:S1471-4906(26)00133-X. doi: 10.1016/j.it.2026.05.008. Online ahead of print. NO ABSTRACT PMID:42285831 | DOI:10.1016/j.it.2026.05.008

Trends Immunol. 2026 Jun 12:S1471-4906(26)00134-1. doi: 10.1016/j.it.2026.05.009. Online ahead of print. NO ABSTRACT PMID:42285830 | DOI:10.1016/j.it.2026.05.009

Trends Immunol. 2026 Jun 12:S1471-4906(26)00135-3. doi: 10.1016/j.it.2026.05.010. Online ahead of print. NO ABSTRACT PMID:42285829 | DOI:10.1016/j.it.2026.05.010

Trends Immunol. 2026 Jun 10:S1471-4906(26)00130-4. doi: 10.1016/j.it.2026.05.005. Online ahead of print. ABSTRACT Bioelectric signaling may represent an emerging layer of macrophage communication. This forum discusses how membrane-potential dynamics, ion fluxes, and context-dependent intercellular coupling may coordinate macrophage responses within tissues, highlighting a potential new dimension of immune regulation with broad implications for tissue-level immunity. PMID:42270522 … Read more

Trends Immunol. 2026 Jun 9:S1471-4906(26)00129-8. doi: 10.1016/j.it.2026.05.004. Online ahead of print. ABSTRACT Immune-mediated inflammatory disorders, such as inflammatory bowel diseases, are characterized by chronic inflammation and damage to the intestinal barrier. Several of the current therapeutic strategies for inflammatory diseases attempt to decrease inflammation but cause side effects in a significant fraction of patients without … Read more