Trends in Immunology

Trends Immunol. 2026 Mar 17:S1471-4906(26)00034-7. doi: 10.1016/j.it.2026.02.003. Online ahead of print. ABSTRACT Cheng et al.’s recent study identifies the Cullin3-RING E3 ubiquitin ligase complexes (CRL3) adaptor protein Kelch-like protein 6 (KLHL6) as a proteostasis regulator whose downregulation in chronically stimulated T cells leads to the accumulation of thymocyte selection-associated high mobility group box protein and … Read more

Trends Immunol. 2026 Mar 17:S1471-4906(26)00009-8. doi: 10.1016/j.it.2026.01.006. Online ahead of print. ABSTRACT IgE contributes to allergy, but its cellular sources are rare and hard to identify. Genetic fate mapping and single-cell sequencing approaches have now revealed that two cell populations maintain IgE: long-lived IgE plasma cells (PCs) and ‘type 2’ memory B cells. This forum … Read more

Trends Immunol. 2026 Mar 12:S1471-4906(26)00036-0. doi: 10.1016/j.it.2026.02.005. Online ahead of print. ABSTRACT Psoriatic arthritis (PsA) is a chronic inflammatory disease that primarily affects the skin, joints, and entheses. Growing evidence implicates alterations at the gut and skin barriers in PsA pathogenesis. These sites play a crucial role in tissue homeostasis, and their disruption can contribute … Read more

Trends Immunol. 2026 Mar 11:S1471-4906(26)00039-6. doi: 10.1016/j.it.2026.02.008. Online ahead of print. ABSTRACT The rapid development of allogeneic engineered therapeutic cells has intensified the challenge of host immune-mediated rejection. Advances in molecular immunology, genetic engineering, and induced pluripotent stem cell-based multigene editing have enabled the creation of ‘stealth’ allogeneic cells designed to evade immune detection while … Read more

Trends Immunol. 2026 Mar 11:S1471-4906(26)00038-4. doi: 10.1016/j.it.2026.02.007. Online ahead of print. ABSTRACT Li et al. described a tumor-derived neuroimmune mechanism that promotes clearance of established amyloid pathology in Alzheimer’s disease. secreted cystatin C activates TREM2-dependent microglial phagocytosis, reducing plaques and improving cognition. This work introduces a context-dependent neuroimmune-modulatory strategy that shifts Alzheimer’s therapy from broad … Read more

Trends Immunol. 2026 Mar 7:S1471-4906(26)00035-9. doi: 10.1016/j.it.2026.02.004. Online ahead of print. ABSTRACT CD8+ T cell migration is central to host defense, enabling clonal selection, tissue infiltration, and elimination of infected cells. While chemokines guide these cells by activating Rac for F-actin polymerization, recent studies reveal a complementary mechanism through Rho activation. This pathway relies on … Read more

Trends Immunol. 2026 Mar 5:S1471-4906(26)00017-7. doi: 10.1016/j.it.2026.02.002. Online ahead of print. ABSTRACT De Leeuw et al. conducted human observational and murine studies to establish the combined role of parental aeroallergen sensitization and early-life respiratory syncytial virus infection in asthma development. The findings reveal synergistic effects driving immunological, pathological, and physiological changes resembling asthma, advancing the … Read more

Trends Immunol. 2026 Mar 3:S1471-4906(25)00316-3. doi: 10.1016/j.it.2025.12.008. Online ahead of print. ABSTRACT Bile acids are cholesterol derivatives, generated by the coordinated intervention of human and bacterial genes, functioning as endogenous ligands for multiple transcription factors and receptors throughout the body. While only two primary bile acids are generated by the human liver, the intestinal microbiota … Read more

Trends Immunol. 2026 Mar 2:S1471-4906(26)00014-1. doi: 10.1016/j.it.2026.01.011. Online ahead of print. ABSTRACT During pregnancy, complex interactions of maternal immune cells and fetal extravillous trophoblasts (EVTs) orchestrate placentation, immune tolerance, and immune defense. This forum article highlights important discoveries and outstanding questions on how the activation of decidual natural killer and T cells, through recognition of … Read more

Trends Immunol. 2026 Feb 27:S1471-4906(26)00002-5. doi: 10.1016/j.it.2026.01.002. Online ahead of print. ABSTRACT Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation … Read more