With the rapid advancement of nanotechnology, the application of nanomedicine has become increasingly widespread, demonstrating remarkable potential for highly precise targeting and efficacious drug delivery. Compared to conventional drug delivery appr…
Advanced endometrial cancer (EC) poses significant therapeutic challenges due to molecular heterogeneity and immune evasion. Immune checkpoint inhibitors (ICIs) show promise, particularly in mismatch repair-deficient (MMRd) and POLE-mutated subtypes, b…
Cancer remains the leading cause of death worldwide. Despite decades of continuous research, limitations persist in existing therapeutic approaches. Conventional strategies such as surgery, chemotherapy, and radiotherapy, though advanced, face challeng…
Cancer remains a leading cause of mortality worldwide, with rising incidence and death rates continuing to rise. While conventional treatments such as surgery, radiotherapy, and chemotherapy form the backbone of cancer care, they are often limited by a…
The gut microbiome critically regulates antitumor immunity through its metabolic byproducts, which serve as pivotal mediators of host-microbe crosstalk in tumor immunotherapy. This review synthesizes cutting-edge evidence on how microbial metabolites—i…
Gouty arthritis (GA), a condition characterized by monosodium urate (MSU) crystal deposition and NLRP3 inflammasome-driven inflammation, is a result of a complex interplay between hyperuricemia and immune dysregulation, which leads to systemic complica…
Follicular helper T cells (Tfh) are a Th cell subset that directly assists B cells in functioning, and their development is regulated by various factors. Among them, the initial regulation leads to phenotypic heterogeneity, while the regulation of thei…
BackgroundChronic Obstructive Pulmonary Disease (COPD) is a leading cause of global mortality, characterized by chronic inflammation and abnormal immune responses in the lower airways. Recent studies have highlighted the critical role of immune functio…
Primary Sjögren’s disease (SjD) is a chronic systemic autoimmune disorder whose pathogenesis remains incompletely understood. Current clinical interventions demonstrate limited efficacy, yielding suboptimal therapeutic outcomes. microRNAs (miRNAs)–crit…
Immunoglobulin G4-related disease (IgG4-RD) is a rare, multisystemic fibro-inflammatory condition affecting various organs, including kidneys, lungs, nasal cavity, pancreas, salivary glands, and orbit. Anti-neutrophil cytoplasmic antibody (ANCA)-associ…
