Glioblastoma (GBM) remains one of the most lethal and treatment-refractory brain tumors, characterized by rapid recurrence and profound resistance to conventional therapies. The mechanisms underlying GBM resilience converge on two interdependent axes: …
Cellular senescence constitutes the core biological basis of body aging. It not only directly drives the occurrence and progression of multiple age-related diseases, but also establishes and maintains a chronic inflammatory microenvironment through the…
PRDM1 is a key transcriptional repressor that plays a vital role in B- and T-cell differentiation, immune regulation, and tumor suppression. PRDM1 functions through its C2H2 zinc finger domains and proline-rich region, which mediate transcriptional rep…
Chronic rhinosinusitis with eosinophilia (ECRS) is a refractory sinusitis characterized by eosinophilia in the nasal mucosa and peripheral blood. In ECRS, multiple nasal polyps are present in the ethmoid sinuses, and the disease is often accompanied by…
Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease with an increasing incidence. The complex pathogenesis of AIH poses significant challenges for clinical treatment. In recent years, with the introduction of cutting-edge concepts su…
Skin fibrosis encompasses a spectrum of disorders, including hypertrophic scars, keloids, systemic sclerosis and lymphedema, that arise from distinct initiating insults but converge on persistent fibroblast activation, immune dysregulation and excessiv…
Influenza viruses remain major global health threats due to their rapid evolution and complex interactions with host regulatory systems. While genetic variation is a key driver of viral pathogenicity and host adaptation, growing evidence indicates that…
Pulmonary gas exchange and host defense depend on the dynamic coordination of resident and recruited macrophage populations. Historically, macrophage functions have often been interpreted through the classic M1/M2 dichotomy; however, this binary framew…
Sepsis is a systemic inflammatory response syndrome triggered by infection, frequently complicated by severe organ dysfunction and high mortality rates. Recent studies of intestinal epithelial function and the gut microbiota have highlighted their pivo…
Renal ischemia-reperfusion injury (IRI) is a major pathological driver of acute kidney injury (AKI), for which effective therapeutic strategies remain lacking. Recently, novel forms of programmed cell death (PCD), including pyroptosis, ferroptosis, cup…
