Asthma is a heterogeneous chronic airway disease characterized by complex inflammation. Pyroptosis, a pro-inflammatory form of programmed cell death mediated by gasdermin (GSDM) family proteins, has recently emerged as a critical amplifier of airway in…
Periodontitis, a chronic inflammatory disease leading to irreversible tissue destruction, is a highly prevalent oral disease. The clinical management of periodontitis is challenging because conventional treatments like mechanical debridement and antibi…
Environmental exposure to heavy metals, such as cadmium, lead, arsenic, and copper, represents a significant yet underappreciated threat to the long-term survival of kidney transplants. Accumulating epidemiological evidence consistently links even low-…
Ferroptosis, recently proposed as a novel type of cell death, is characterized by unique characteristics and recognition functions. It is involved in diverse physiological processes and in the onset and progression of various diseases and is characteri…
Prostate cancer management has long been challenged by the limitations of traditional screening tools like PSA testing, which contribute to significant rates of overdiagnosis and overtreatment. While advanced imaging such as multiparametric MRI (mpMRI)…
Skin cancer is one of the most frequently diagnosed neoplasms in dogs, encompassing a range of malignancies with significant clinical implications. Among them, mast cell tumors (MCTs), melanomas, and squamous cell carcinomas (SCCs) signify the most com…
Synthetic biology is being widely applied in tumor therapy, ranging from attenuating microbial toxicity to constructing synthetic gene circuits and developing CAR-T cells, all of which are reshaping the landscape of cancer immunotherapy. In this review…
Alveolar macrophages (AMs), a type of immune cell, display remarkable plasticity and manifest diverse responses to stimuli by differentiating into distinct subgroups. These phenotypically distinct macrophage subtypes are primarily categorized as either…
BackgroundPediatric Acute-onset Neuropsychiatric Syndromes (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS) are characterized by sudden-onset neuropsychiatric symptoms. Growing evidence indica…
Pulmonary fibrosis is a chronic interstitial lung disease with an incompletely understood pathogenesis, and currently, effective treatment strategies remain elusive. Neutrophils, as pivotal effector cells of the innate immune system, are integral to th…
