Sepsis is a syndrome of inflammatory response syndrome (SIRS) triggered when the host is exposed to bacterial, viruses, and other infectious agents. The resulting inflammation compromises intestinal integrity, and this gut injury subsequently amplifies…
Non-alcoholic fatty liver disease (NAFLD) is a widespread chronic liver disorder, affecting nearly a quarter of the global population. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular …
Research in the field of Liquid-liquid phase separation (LLPS) breaks through the classical theory of gene mutation in the mechanism of tumorigenesis and provides a new perspective for comprehending tumors from a network regulation standpoint. Although…
Glioblastoma (GB) is the most aggressive tumor of the central nervous system (CNS), accounting for almost 80% of all primary brain tumors. Despite standard-of-care consisting of surgical resection, when possible, adjuvant radiotherapy (RT) and chemothe…
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques, tau hyperphosphorylation, and chronic neuroinflammation. While neuroinflammation—mediated by microglial and astrocyte activation—has long b…
COVID-19 and seasonal influenza have taken a huge toll on the global economy and global health. Given the potential of COVID-19 to transform into a chronic epidemic akin to seasonal influenza, the influenza virus and SARS-CoV-2 will continue to be a si…
RNA-Sequencing (RNA-Seq) studies using bovine samples from Mycobacterium avium subsp. paratuberculosis (MAP)-infected animals have identified a range of differentially expressed mRNAs with potential as biomarkers for MAP infection. As bioinformatic too…
Around 10% of the Western population is diagnosed with asthma, and this percentage is only expected to increase in the coming years. Allergic asthma often develops during early infancy and is characterized by chronic pulmonary type 2 inflammation and a…
Metabolic dysfunction-Associated Steatohepatitis (MASH), a progressive liver disease characterized by disturbances of lipid metabolism and chronic inflammation response in liver has become the most prevalent chronic liver diseases worldwide. Recent sin…
Urothelial carcinoma (UC) represents the most common pathological type of bladder cancer. For patients with locally advanced or metastatic UC (la/m UC), the standard of care with platinum-based chemotherapy as the cornerstone has greatly improved the s…
