BackgroundMacrophages are plastic innate immune cells that couple inflammatory signaling with microvascular injury and alloimmune responses, thereby shaping rejection phenotypes and chronic allograft dysfunction after kidney transplantation. Yet, the m…
BackgroundMacrophages are plastic innate immune cells that couple inflammatory signaling with microvascular injury and alloimmune responses, thereby shaping rejection phenotypes and chronic allograft dysfunction after kidney transplantation. Yet, the m…
The pathogenesis of gouty arthritis (GA) begins with the deposition of monosodium urate (MSU) crystals in the joints. This crystal deposition triggers a critical inflammatory response by activating the NLRP3 inflammasome, which in turn drives the matur…
The pathogenesis of gouty arthritis (GA) begins with the deposition of monosodium urate (MSU) crystals in the joints. This crystal deposition triggers a critical inflammatory response by activating the NLRP3 inflammasome, which in turn drives the matur…
Crohn’s disease (CD) is a chronic, relapsing inflammatory bowel disease characterized by transmural inflammation. Its clinical presentation and disease course are highly heterogeneous across individuals, and the global disease burden continues to rise….
BackgroundPsoriatic arthritis (PsA) is a heterogeneous, immune-mediated disease affecting joints, entheses, the axial skeleton, and skin. Although many targeted therapies have emerged, unmet needs remain in musculoskeletal control, comorbidity manageme…
Periodontitis is a chronic oral infectious inflammatory disease caused by dental plaque, affecting approximately 35% – 50% of adults globally. Far from a localized oral condition, it exerts systemic pathogenic effects through multiple biological condui…
Small cell lung cancer (SCLC) remains one of the most aggressive malignancies, characterized by limited therapeutic options and persistently poor survival outcomes. This review summarizes recent advances in understanding the immunosuppressive tumor mic…
Dyslipidemia and obesity are key risk factors for cardiometabolic diseases and are also linked to osteoporosis and other bone disorders. Evidence shows lipid metabolism influences bone homeostasis largely through immune regulation. This review first ex…
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an autoimmune peripheral neuropathy primarily characterized by macrophage-mediated demyelination. Studies have identified that some patients possess autoantibodies against contactin-1 (CNTN1),…
