As an immune checkpoint molecule, Tim-3 is expressed on T cells and other immune cells, and is crucial for maintaining immune homeostasis and preventing excessive inflammation. This article reviews the changes in expression, mechanism of action, and cl…
BackgroundThe neuroimmune axis plays a crucial role in maintaining pulmonary homeostasis and influencing disease outcomes. Although significant progress has been made in this interdisciplinary field, the research remains scattered, and a unified unders…
BackgroundPrimary Antiphospholipid Syndrome (PAPS) is a systemic autoimmune disorder characterized by arterial and/or venous thrombosis and obstetric morbidity. Arterial thrombosis, although less frequent than venous events, is associated with substant…
ObjectiveImmune checkpoint inhibitor-induced bullous pemphigoid (ICI-BP) is a rare and complex cutaneous immune-related adverse event (cirAE) that often impacts the continuation of ICI therapy. Currently, there are no prospective clinical studies addre…
BackgroundMetastatic castration-resistant prostate cancer (mCRPC) remains a clinically aggressive and lethal disease. Circulating tumor DNA (ctDNA), as a minimally invasive biomarker, has shown prognostic utility in several solid tumors. However, its c…
AimIn proficient mismatch repair (pMMR) non metastatic rectal cancer, standard neoadjuvant chemoradiotherapy (nCRT) yields low pathological and clinical complete response rates. Early randomized trials suggest adding PD 1 inhibitors may increase respon…
ObjectiveAmid acknowledged sex-based disparities in immune system response, the effect of patients’ sex on the efficacy of immune checkpoint inhibitors (ICIs) treatment remains inconsistent across cancers, and even inconclusive in esophageal squamous-c…
BackgroundHepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is the leading cause of cancer-related deaths worldwide. The majority of patients with HCC are diagnosed at an advanced stage, resulting in limited treatment o…
IntroductionThis study aimed to explore the efficacy and safety of neoadjuvant immunotherapy combination regimens in locally advanced resectable esophageal squamous cell carcinoma (ESCC), and evaluate the pros and cons of different regimens and their i…
BackgroundCervical cancer is one of the most common cancers among women worldwide. For patients with recurrent or metastatic cervical cancer (R/MCC) after surgery or radiotherapy, drug therapy is the primary treatment modality. Currently, head-to-head …
