BackgroundThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had immense global consequences, leading to widespread illness, deaths, and devastated economies. Despite this, Africa has experienced a high prevalence of asym…
IntroductionUlcerative colitis (UC) is driven by mucosal inflammation and epithelial injury. Single cell RNA sequencing (scRNA-seq) enables high resolution profiling of immune, stromal and epithelial compartments in UC, whilst spatial transcriptomic (S…
ObjectiveThe immunological mechanisms underlying the syphilis serofast remain incompletely elucidated. This systematic review and meta-analysis aims to quantify the association between key immune indicators and serofast.MethodsWe systematically searche…
BackgroundMultiple sclerosis (MS) is a chronic immune-mediated neurodegenerative disorder of the central nervous system and a leading cause of disability among young adults. The disease exhibits considerable heterogeneity in clinical progression, with …
IntroductionThis meta-analysis aimed to evaluate the safety and efficacy of anti-IL-5 monoclonal antibody (anti-IL-5 mAb) as a second-line therapy for chronic rhinosinusitis with nasal polyps (CRSwNP).Materials and methodsFour databases (PubMed, Web of…
BackgroundRheumatoid arthritis (RA) is a heterogeneous autoimmune disease in which serological status, defined by rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), influences disease course. Alterations of the gut microbiome have…
ObjectiveThis study evaluates the dose-response relationships between multiple exercise parameters (volume, duration, and intensity) and inflammatory modulation (C-reactive protein [CRP], interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α], and adipo…
ObjectiveThis study aims to identify and analyze the top 100 most-cited articles in the NLRP3 research field to uncover research trends, key contributors, and collaborative networks, thereby providing insights into the development and future directions…
BackgroundRelapsing-Remitting Multiple Sclerosis (RRMS) is a chronic inflammatory demyelinating disease affecting the central nervous system, characterized by complex pathogenesis and increasing annual incidence rates. Although current clinical interve…
BackgroundAxial spondyloarthritis (axSpA) is a chronic inflammatory disease affecting the spine and sacroiliac joints. Emerging evidence suggests that the gut microbiota may contribute to its pathogenesis, but findings on microbial diversity and compos…
