Protective effect and possible mechanisms of resveratrol in animal models of spinal cord injury: a preclinical systematic review and meta-analysis

BackgroundResveratrol has shown potential neuroprotective effects in experimental spinal cord injury (SCI), but its overall efficacy has not been systematically evaluated. This study aimed to assess the effects of resveratrol on locomotor recovery and …

Efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic agents in advanced cervical cancer: a systematic review and meta-analysis

BackgroundAdvanced cervical cancer (aCC) is associated with a poor prognosis for patients. While immune checkpoint inhibitors (ICIs) have demonstrated potential therapeutic benefits, their effectiveness can be hindered by inherent resistance mechanisms…

Efficacy and safety of upadacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis

BackgroundRheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovial inflammation, leading to progressive joint destruction and functional impairment. Although conventional synthetic disease-modifying antirh…

Research landscape, thematic evolution, and translational insights of immune checkpoint inhibitor-induced colitis: a bibliometric analysis (2006-2025)

BackgroundIn recent years, immune checkpoint inhibitors have been widely adopted in cancer therapy. However, their use is frequently associated with the development of colitis. This study employs bibliometric methods to analyze the knowledge structure …

First-line immunotherapy for advanced hepatocellular carcinoma: a network meta-analysis of randomized trials with overall and HBV/HCV-stratified efficacy and safety

BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized the front-line treatment of advanced hepatocellular carcinoma (HCC). However, the comparative efficacy and safety of different ICI-based regimens—and their consistency across etiologic s…

Studies on allergic diseases and B cells in the past 20 years: a bibliometric analysis via CiteSpace and VOSviewer

BackgroundAllergic diseases represent a growing global health burden, and B cells have emerged as central yet incompletely defined regulators of IgE-mediated immunity and tolerance. There is currently a lack of bibliometric research on allergic disease…

Induction immunochemotherapy followed by concurrent chemoradiotherapy improves survival in unresectable esophageal cancer: a systematic review, meta-analysis, and network meta-analysis

BackgroundConcurrent chemoradiotherapy (CCRT) remains the standard treatment for unresectable esophageal cancer (EC). However, the clinical benefits of combining immunotherapy with CCRT for unresectable EC remain controversial. Therefore, we conducted …

Systematic review and network meta-analysis of performance of the Sapporo criteria, the revised Sapporo criteria, and the 2023 ACR/EULAR APS classification criteria for patients with antiphospholipid syndrome

BackgroundAntiphospholipid syndrome (APS) lacks systematic comparative evidence for the diagnostic performance of its three classification criteria, namely the 1999 Sapporo criteria, 2006 Revised criteria, and 2023 ACR criteria. This study aimed to com…

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