BackgroundBreast cancer (BC) is the most common malignant tumor among women worldwide. Radiotherapy (RT) is a primary treatment modality; however, local recurrence driven by radioresistance frequently undermines its efficacy.MechanismsGrowing evidence …
BackgroundThis study evaluates the quality of study design, potential biases, and evidence strength for childhood risk factors associated with allergic rhinitis (AR), while summarizing the key identified factors.MethodsThe protocol for this review was …
BackgroundInflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by dysregulated mucosal immunity. Despite major advances in therapies, a high proportion of patients do not achieve or sustain remission. Cellular immunother…
BackgroundLower peripheral lymphocyte counts are associated with mortality in sepsis, but evidence across related adaptive immune-cell compartments has not been systematically quantified.MethodsNine databases were searched from inception through 7 Augu…
BackgroundThere is an increasing number of studies on the protective effects of natural products on the intestinal barrier through multiple targets. However, the landscape of knowledge structure and emerging frontiers remains incompletely characterized…
BackgroundLung cancer remains one of the most common and lethal malignancies worldwide. The advent of immune checkpoint inhibitors (ICIs) has substantially improved survival outcomes in patients with advanced disease; nevertheless, a considerable propo…
BackgroundChildhood adversity is increasingly recognized as an important early-life psychosocial exposure that may shape long-term immune function and contribute to autoimmune diseases through chronic stress, neuroendocrine dysregulation, and inflammat…
BackgroundBispecific antibodies (BsAbs) have emerged as a promising strategy for solid tumor treatment, yet their comparative efficacy and safety versus other antitumor therapies remain unclear.Materials and methodsLiterature was systematically searche…
BackgroundBreast cancer (BC) remains the most common malignant tumor in women worldwide and a leading cause of cancer-related deaths. Despite therapeutic advances, patients with advanced BC, particularly triple-negative breast cancer (TNBC), still face…
Although daratumumab has been reported to significantly improve the prognosis of multiple myeloma (MM), its efficacy in patients with cytogenetically high-risk MM (HRMM) remains unclear. This meta-analysis aims to evaluate the effect of daratumumab on …
