Complement response to burn injury: systematic review and meta-analysis of patient and animal studies

BackgroundBurns often induce a profound inflammatory response that contributes to immune dysfunction, tissue damage, and adverse clinical outcomes. Activation of the complement system plays a crucial role in this response, yet findings across different…

The efficacy and safety of disitamab vedotin plus immunotherapy in locally advanced or metastatic solid tumors: a systematic review and meta-analysis

BackgroundThe combination of disitamab vedotin (DV), a novel human epidermal growth factor receptor 2 (HER2)-targeting antibody-drug conjugate, with immunotherapy represents a promising strategy for locally advanced or metastatic solid tumors. However,…

Relationship between COVID-19 and “three inflammations and one deafness”: a systematic review and meta-analysis

BackgroundThe relationship between “three inflammations and one deafness” (allergic rhinitis, pharyngitis, otitis media, tinnitus, and deafness) and coronavirus disease 2019 (COVID-19) is currently unclear, and this study aims to investigate their corr…

Controlling nutritional status score predicts clinical outcome in cancer patients treated with immune checkpoint inhibitor: a systematic review and meta-analysis

BackgroundTo investigate the association between pretreatment controlling nutritional status (CONUT) score and clinical outcomes for cancer patients treated with immune checkpoint inhibitors (ICIs).MethodsWe conducted a comprehensive literature search …

Radiotherapy plus immune checkpoint inhibitors versus immune checkpoint inhibitors alone for non-small cell lung cancer with bone metastases: a systematic review and meta-analysis of comparative cohort studies

BackgroundBone metastases are a frequent and clinically consequential complication of advanced non-small cell lung cancer (NSCLC), associated with substantial morbidity and poor survival. Whether adding radiotherapy (RT) to immune checkpoint inhibitors…

Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials

IntroductionCreatine supplementation is widely recognized for its ergogenic effects on strength and body composition. Recent studies have explored its potential anti-inflammatory properties, particularly in exercise-induced stress and aging-related chr…

Efficacy and safety of cadonilimab combined with chemotherapy for gastric or gastroesophageal junction adenocarcinoma: a single-arm meta-analysis

BackgroundImmune checkpoint inhibitors (ICIs) combined with chemotherapy have become an important area of clinical investigation in the gastric cancer (GC) and gastroesophageal junction cancer (GEJC). In recent years, bispecific antibody therapies have…

Structural and temporal dynamics of nano-based therapies in ulcerative colitis: history, hotspots, and emerging trends

BackgroundNanomaterial-based therapies have emerged as a promising approach for ulcerative colitis (UC). To systematically map the field, we performed a bibliometric analysis of research over the past 25 years, aiming to reveal knowledge evolution, cor…

Dual role of rVSV vectors in prophylactic and therapeutic innovation: a comprehensive bibliometric and clinical trial perspective

BackgroundRecombinant Vesicular Stomatitis Virus (rVSV) vector vaccines have become essential in combating emerging viral diseases and have shown promise in immunotherapy, particularly in the discipline of cancer treatment. Although extensive research …

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