BackgroundSevere lupus nephritis (LN) remains difficult to manage despite standard immunosuppressive therapy. Immunoadsorption (IA) has been increasingly used as an adjunctive treatment. However, comparative evidence across different IA columns is limi…
High-resolution, high-throughput single-cell omics has transformed our understanding of autoimmune disease pathogenesis. We synthesise recent single-cell omics advances across six autoimmune diseases—systemic sclerosis, systemic lupus erythematosus, Sj…
BackgroundInfluenza imposes a heavy global public health burden, with current therapies limited by drug resistance and side effects. Natural products have antiviral potential, and intranasal delivery targets the respiratory tract. However, preclinical …
As an immune checkpoint molecule, Tim-3 is expressed on T cells and other immune cells, and is crucial for maintaining immune homeostasis and preventing excessive inflammation. This article reviews the changes in expression, mechanism of action, and cl…
BackgroundThe neuroimmune axis plays a crucial role in maintaining pulmonary homeostasis and influencing disease outcomes. Although significant progress has been made in this interdisciplinary field, the research remains scattered, and a unified unders…
BackgroundPrimary Antiphospholipid Syndrome (PAPS) is a systemic autoimmune disorder characterized by arterial and/or venous thrombosis and obstetric morbidity. Arterial thrombosis, although less frequent than venous events, is associated with substant…
ObjectiveImmune checkpoint inhibitor-induced bullous pemphigoid (ICI-BP) is a rare and complex cutaneous immune-related adverse event (cirAE) that often impacts the continuation of ICI therapy. Currently, there are no prospective clinical studies addre…
BackgroundMetastatic castration-resistant prostate cancer (mCRPC) remains a clinically aggressive and lethal disease. Circulating tumor DNA (ctDNA), as a minimally invasive biomarker, has shown prognostic utility in several solid tumors. However, its c…
AimIn proficient mismatch repair (pMMR) non metastatic rectal cancer, standard neoadjuvant chemoradiotherapy (nCRT) yields low pathological and clinical complete response rates. Early randomized trials suggest adding PD 1 inhibitors may increase respon…
ObjectiveAmid acknowledged sex-based disparities in immune system response, the effect of patients’ sex on the efficacy of immune checkpoint inhibitors (ICIs) treatment remains inconsistent across cancers, and even inconclusive in esophageal squamous-c…
