IntroductionAccessible biomarkers that reflect immune-inflammatory activity may support the diagnosis and monitoring of patients with rheumatic diseases (RDs). We conducted a systematic review and meta-analysis to investigate the systemic immune-inflam…
BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized cancer treatment; however, durable clinical benefit is limited to a subset of patients. Long non-coding RNAs (lncRNAs) have emerged as important regulators of tumor biology and immune re…
ObjectiveThis study aims to summarize and appraise the credibility of existing epidemiological evidence on the association between periodontal diseases (PDs) and the risk of site-specific cancers.MethodsPubMed, Embase, and Cochrane Library were searche…
Immune checkpoint inhibitor (ICI) therapy for colorectal cancer (CRC) can be accompanied by endocrine adverse events, yet the comparative risk across commonly used regimens remains unclear. We therefore conducted a network meta-analysis of randomized c…
BackgroundDespite the proven efficacy of KRAS G12C inhibitors (KRAS G12Ci) in solid tumors, evidence from direct comparisons with standard of care is scarce, and no analysis has investigated the potential immunological basis for differential responses….
Glymphatic transport, meningeal lymphatic drainage, and meningeal immunity have been implicated in metabolic waste clearance, cerebral edema formation, and the regulation of neuroinflammation after stroke. However, the available evidence remains fragme…
Myocardial infarction (MI) remains a leading cause of cardiovascular mortality worldwide. Despite significant advances in reperfusion strategies and pharmacotherapy, persistent inflammation and adverse ventricular remodeling continue to underlie poor l…
IntroductionType 1 diabetes is characterized by autoimmune destruction of pancreatic β‑cells, whereas type 2 diabetes involves chronic low‑grade systemic inflammation. Stem cell therapy, through both direct cell replacement and immunomodulation, holds …
BackgroundEosinophilic esophagitis (EoE) is a chronic, immune-mediated esophageal disease defined by the combination of clinical symptoms of esophageal dysfunction and histological evidence of eosinophilic infiltration (≥15 eosinophils per high-power f…
BackgroundBleeding is the predominant clinical manifestation and one of the leading causes of death of Wiskott-Aldrich syndrome (WAS). However, significant discrepancies in reported bleeding phenotypes persist.ObjectiveThis systematic review and meta-a…
