Assessing the role of vitamin D in the prevention and management of chronic rhinosinusitis: a systematic review and meta-analysis

BackgroundChronic rhinosinusitis (CRS) is a prevalent inflammatory disorder that significantly impairs quality of life. Emerging evidence suggests that vitamin D plays an immunomodulatory role in sinonasal inflammation; however, its clinical significan…

Values and preferences of patients with inborn errors of immunity and their caregivers: a systematic review

Understanding patient values and preferences can provide valuable insight and help improve patient care for patients with inborn errors of immunity (IEIs). Therefore, this review sought to systematically review the values and preferences of patients wi…

Efficacy and safety of mesenchymal stem cell transplantation for progressive multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials with clinical implications for patient stratification and treatment optimization

BackgroundProgressive multiple sclerosis (PMS) is a disabling demyelinating disease characterized by irreversible neurodegeneration. Unlike relapsing-remitting MS, for which many disease-modifying therapies exist, treatment options for PMS are extremel…

Efficacy and safety of immunotherapy combined with chemoradiotherapy in limited-stage small cell lung cancer: a systematic evaluation and meta-analysis of randomized controlled trials

BackgroundConcurrent chemoradiotherapy (cCRT) remains the standard treatment for patients diagnosed with limited-stage small-cell lung cancer (LS-SCLC); however, recurrence rates remain high and prognosis remains poor. This study collected data regardi…

Prognostic significance of tumoral Siglec-15 expression in solid tumors: a systematic review and meta-analysis

BackgroundSiglec-15 has emerged as a novel immune checkpoint molecule and a potential therapeutic target in solid tumors. Previous studies reported inconsistent prognostic significance of tumoral Siglec-15 expression across cancer types. We therefore c…

Immunomodulation for stroke-associated pneumonia: a systematic review of mechanistic insight and emerging therapeutic strategies in animal models

Backgrounds and aimsStroke-associated pneumonia (SAP) is a major infectious complication that increases mortality after stroke. Stroke-induced immunosuppression has been proposed as a key driver of SAP, supporting the rationale for immunomodulation. Th…

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