This manuscript reviews the current evidence describing the relationships between surgical trauma, altered intestinal permeability, dysbiosis, inflammasome activation, and postoperative inflammation in the development of AL. Surgical tissue disruption …
IntroductionMedication-overuse headache (MOH) develops when drugs intended for acute pain relief lower the threshold for headache chronification. The biological mechanisms driving this transition remain poorly understood. We aim to synthesize current e…
BackgroundVascularized composite allotransplantation (VCA) joins skin, muscle, bone, nerve, and vessels into a single graft that is both highly immunogenic and mechanically complex. Biopolymers, natural or synthetic, can provide structural scaffolding,…
ObjectiveFerroptosis, an iron-dependent regulated cell death mechanism, has recently gained attention for its crucial role in tumor progression and immune regulation. Gastric cancer (GC), one of the most common and deadly malignancies worldwide, remain…
BackgroundPatients with inflammatory bowel disease (IBD) are at increased risk of colorectal cancer (CRC). Statins exhibit anti-inflammatory and anticancer properties, and although prior meta-analyses have suggested a possible reduction in CRC risk amo…
BackgroundHuman papillomavirus (HPV) vaccination is a cornerstone of global strategies to prevent HPV-associated malignancies; however, uncertainties persist regarding its long-term efficacy, immunogenicity, and safety across populations, vaccine formu…
BackgroundThis study explored whether integrating innovative immunotherapies targeting costimulatory or co-inhibitory pathways beyond standard PD-1, PD-L1, and CTLA-4 treatments affects hepatic adverse events. We further analyzed liver-related side eff…
IntroductionPompe disease, a rare autosomal recessive metabolic myopathy, is primarily treated with enzyme replacement therapy (ERT); however, ERT response depends on several factors, including ERT initiation age, dose, and cross-reactive immunological…
BackgroundMSCs are an important component of the TME and play a key role in tumor progression. Based on existing in vitro studies, this research aims to investigate the role of mesenchymal stem cells in the EMT of HNSCC and its related mechanisms.Metho…
BackgroundThe efficacy of CD38 monoclonal antibody (mAb)-based quadruplet regimens versus triplet regimens in newly diagnosed multiple myeloma (NDMM) patients with high-risk cytogenetics remains controversial. This meta-analysis aims to consolidate evi…
