Stanbery et al. show that ILC2s are largely dispensable, but tuft cells remain essential for helminth clearance during secondary infection. Tuft cells are not required for Th2 priming. Instead, tuft cell effectors directly activate memory Th2 cells in …
During chronic viral infection, CD8+ T cell exhaustion is closely linked to altered migration and tissue residency. Shen et al. identify a reciprocal KLF2-KLF3 transcriptional circuit that controls cellular localization and show that enforcing T cell m…
Cellular senescence is traditionally linked to aging and tissue dysfunction, yet whether beneficial p16High cells can protect against acute lethal stress remains unknown. Triana-Martinez et al. demonstrate that the BNT162b2 mRNA vaccine exerts strong p…
Variation in antibody genetics, as illustrated in the accompanying paper by Corcoran et al., can present a challenge to the development of population-wide protective vaccines. Fischer, Corcoran, et al. investigate influenza-specific antibodies to obtai…
Transcription factor RORγt is a central regulator of type 3 immunity, essential for host defense and tissue homeostasis. Fukui et al. identify a hierarchical CNS11-CNS9 enhancer cascade that governs RORγt expression across innate lymphocytes and antige…
To identify factors that can mediate post-ART HIV control, Ma et al. performed “omics” on PBMCs from PWH from 4 analytical treatment interruption cohorts. NK and T cell features were identified, and the top two genes in CD4+ T cells predicting delayed …
The genes that encode our antibodies display extensive variation between individuals. Corcoran et al. developed a high-throughput sequence-based method for identifying variations in antibody genes (ImmuneDiscover). This enabled the sequencing of 2,486 …
Sick animals often show reduced social engagement, a form of adaptive behavioral distancing thought to limit pathogen transmission beyond the infected individual. In a recent issue of Cell, Yang et al. identified a defined molecular and anatomical path…
The human antibody repertoire is broadly reactive with carbohydrate antigens represented in the host/self as well as the commensal microbiota. New et al. find that B cells reactive with the glycan constituent N-acetyl-glucosamine arise early in life an…
Vaccines targeting bacterial glycans can elicit inconsistent and/or poor protection in the young. Fryer, Pitt, et al. show that mucosal S. pyogenes infection triggers a glycan-specific B cell response that evolves with age and includes antibody class s…
