Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer
(Immunity 58, 2524–2540.e1–e5; October 14, 2025)
Immunity
A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria
Understanding immunity against Plasmodium vivax, a leading cause of malaria, will accelerate development of vaccines, which are currently lagging. Opi et al. identify important mechanisms and target antigens of protective P. vivax immunity in children,…
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes
Using a dual-recombinase fate-mapping system to trace late-entry invader B cells in germinal centers, Zhou et al. show that across vaccination and influenza infection, invaders preferentially generate memory B cells, whose antibodies target subdominant…
HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice
Broadly neutralizing antibodies are promising therapeutics for ending the HIV pandemic; however, their clinical efficacy is undermined by viral escape. Galvez, Nitido, et al. could drive the therapeutic outcomes of vectored immunotherapy in humanized m…
Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection
Neuroimmune interactions shape host responses to infection, but the molecular role of sensory neurons during viral infection remains unclear. Roger et al. show that HSV-1-activated sensory neurons produce substance P and TAFA4, which act in a tissue-sp…
Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection
γδIELs are essential for intestinal homeostasis, but how their differentiation and cytotoxic function are regulated remains unclear. Xie et al. demonstrate two functionally distinct γδIEL subsets, CD160+TCF1+BCL6+ stem-like and GZMB+BLIMP1+ effector-li…
Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis
Microplastics pose a substantial threat to human health, but their effect on phagocytosis is unknown. Codo et al. find that polystyrene microplastics accumulate in different types of tissue-resident phagocytes, disrupting homeostatic clearance of apopt…
Antibody-mediated feedback modulates interclonal competition in the germinal center
Antibodies generated by prior immune responses regulate B cell responses upon recall immunization. Barbulescu et al. examine whether antibodies produced by an ongoing immune response influence the outcomes of contemporaneous germinal centers (GCs) and …
Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells
Vaccine-induced long-lived plasma cells protect the host by secreting neutralizing antibodies, yet the mechanism regulating their lifespan remains unclear. Here, Zhu et al. reveal that fasting depletes long-lived plasma cells and thus impairs humoral i…
Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis
Emotional stress worsens atopic dermatitis and its overall burden, yet the underlying mechanisms remain unclear. Xie et al. reveal that anxiety amplifies atopic dermatitis through sympathetic nervous system activation. Sympathetic release of norepineph…