Tumor-infiltrating NK cells are often dysfunctional. Ji et al. show that the solid tumor microenvironment metabolome drives proteostasis imbalance and dysfunction in tumor-infiltrating NK cells and demonstrate that deletion of Fli1, a transcriptional r…
While dendritic cells (DCs) are central to adaptive immunity against pathogens, their specific role in maintaining peripheral self-tolerance in humans remains poorly defined. Lu et al. uncover a distinct homeostatic maturation state in human cDC2s (ter…
The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 promotes the formation of positively curved membrane r…
Feedback from circulating antibodies can shape initiating immune responses. Yan et al. examine ongoing germinal center (GC) responses upon immunization with an mRNA-LNP-encoded membrane-bound immunogen displaying three conserved HIV-1 envelope epitopes…
Tissue inflammation introduces unique, and often harsh, environments for immune cells. During allergic airway inflammation, pathogenic ILC2s proliferate robustly and drive pathology, but how do they overcome the nutrient-depleted environment? In this i…
Microglia display remarkable plasticity, with their cellular states evolving in response to developmental stage, regional context, and environmental or pathological stimuli. In this issue of Immunity, Hamagami et al. demonstrate that adaptive reconfigu…
Powerful interferon (IFN)-I-producing capacity distinguishes plasmacytoid dendritic cells (pDCs) from related innate cells. Adams et al. find that, during pDC development, the locus encoding IFN-I genes acquires a unique intranuclear localization and c…
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zhang et al. p…
Defining the antigen specificity of T cell receptors (TCRs) remains a significant barrier to understanding adaptive immunity in various pathologies. In this issue of Immunity, Gaglione et al. report the development of TCRAFT, a novel platform that enab…
Immunotherapeutic approaches to brain aging remain largely preclinical and in early translational stages, and they have focused mostly on modulating innate immunity. In this issue of Immunity, Negredo et al. identify T cells bearing exhaustion-like sig…
