Regulatory T (Treg) cells suppress immune responses and are considered a major barrier to productive anti-tumor immunity. In this issue of Immunity, Huang et al. report that interleukin (IL)-10-producing Treg cells restrain tumor growth by suppressing …
Immune cells from the skull marrow reach the meninges through bone channels. In this issue of Immunity, Eme-Scolan and colleagues show that these channels form neonatally and can be remodeled to alter immune access to the brain’s borders. Their work su…
A long-standing debate in the field asks whether resident tissue macrophages are terminally differentiated or remain capable of changing their fate and function during inflammation. In this issue of Immunity, Verwaerde et al. uncover an IRF4-driven cir…
Ontogeny is a crucial determinant of macrophage function, but it remains unclear how a shared set of transcription factors generate distinct transcriptional programs across macrophage lineages. In this issue of Immunity, Chen et al. discover a transcri…
The water you touch in a river is the last of that which has passed and the first of that which is coming. Thus it is with time present.—Leonardo da Vinci
Microglia adopt diverse states throughout life. Whether these represent fixed lineages or reversible plasticity remains unclear. Hamagami and Kapadia et al. show that reactive microglia switch states through reprogramming of histone modifications at st…
Contemporary immunology research commonly utilizes detailed analyses of immunoglobulin sequences; however, IG immunogenetics remain understudied in rhesus macaques (RMs). Peres et al. combine IG genomic and repertoire sequencing of >100 RMs to provide …
Lucas et al. evaluate the interferon-gamma (IFN-γ) signature against toxicity and efficacy in four neoadjuvant melanoma immunotherapy regimens. IFN-γ-high scores associated with overall favorable efficacy but increased toxicity when anti-CTLA-4 was add…
Mandl and colleagues describe an important gap in our understanding of how antiviral immune mechanisms in individual hosts alter the evolutionary trajectories of viruses as they spread through populations. They propose that bold new experimental system…
Skull marrow communicates with the meninges through bone channels, yet their formation and regulation remain poorly understood. Eme-Scolan et al. show that these channels undergo active remodeling during the neonatal period and can be reshaped by modul…
