While neurons and microglia are known to talk to one another, the signals that regulate their complex, important interactions are not comprehensively defined. Devlin et al. find that the cytokine IL-34 produced by excitatory neurons instructs the devel…
Pancreatic ductal adenocarcinoma is an aggressive cancer characterized by an immunosuppressive tumor microenvironment and limited therapeutic options. Mahat et al. show that a prevalent p53 mutation drives the expression of the chemokine Cxcl1 by bindi…
Clark et al. reveal that tumor-derived cues induce a functional switch in tumor-associated macrophages (TAMs) through decreased expression of NDUFA4, a mitochondrial complex IV subunit. This promotes a shift from pro-tumor Spp1+ TAMs to anti-tumor Cxcl…
The mammalian/mechanistic target of rapamycin (mTOR) signaling pathway integrates critical environmental and metabolic cues to regulate immune cell activation, differentiation, and function. Patel and Powell provide an updated comprehensive review of o…
Parasympathetic neuronal dysfunction is associated with heart failure, yet the underlying mechanism is poorly understood. Here, Li et al. demonstrate that optogenetic activation of the vagus nerve prevents the progression of heart failure by suppressin…
The microbiota’s impact on immune development is well appreciated. Mooser et al. show now that dietary LPS promotes intestinal germinal center reactions and IgA production independently of the microbiota. This work highlights how diet alone can have lo…
DOCK8-deficient patients and mice are prone to food allergy and oral anaphylaxis. Here, Janssen et al. demonstrate that DOCK8 deficiency yields expanded mucosal mast cells and elevated circulating tryptase concentrations. Loss of DOCK8 in T cells impai…
Lack of CD4+ T cell help during acute infections is known to compromise the generation of functional CD8+ T cell memory. van der Heide et al. reveal that this dysfunction is not permanent but rather a transient state of delayed memory maturation. They …
(Immunity 51, 522–534.e1–e7; September 17, 2019)
The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses microglial cGAS-STING-IFN signaling in tauopathy mice. …
