The prostate is an important exocrine gland and barrier tissue of the male reproductive system, yet prostate Trm cells remain uncharted. Takehara et al. utilize functional genetics and single-cell and spatial transcriptomics to identify the molecular r…
Infiltration of glioblastoma (GB) cells into the brain parenchyma and colonization of distant regions are associated with disease recurrence and therapy resistance. Using 3-photon intravital microscopy in an autochthonous GB model, Nebeling et al. iden…
Aging profoundly alters memory T cell immunity, reshaping diversity, differentiation, and function. Adamo et al. review how intrinsic aging programs, antigenic experience, and tissue context shape T cell responses and discuss emerging strategies to rec…
How Foxp3 establishes the epigenetic and transcriptional identity of regulatory T (Treg) cells remains unclear. Murakami et al. demonstrate that Foxp3 cooperates with the AP-1 transcription factor BATF to directly promote chromatin accessibility and ge…
Perinatally acquired persistent viral infections are thought to result in T cell tolerance. Martin et al. show that neonatally LCMV-infected mice mount virus-specific Tfh cell responses that are transcriptionally normal but clonally restricted. These r…
Although long-term dietary effects on the immune system are well established, how short-term high-fat diet (HFD) alters intestinal immunity is less understood. Here, Torrico et al. show that within hours of initiating HFD, microbiota-driven inflammatio…
Stanbery et al. show that ILC2s are largely dispensable, but tuft cells remain essential for helminth clearance during secondary infection. Tuft cells are not required for Th2 priming. Instead, tuft cell effectors directly activate memory Th2 cells in …
During chronic viral infection, CD8+ T cell exhaustion is closely linked to altered migration and tissue residency. Shen et al. identify a reciprocal KLF2-KLF3 transcriptional circuit that controls cellular localization and show that enforcing T cell m…
Variation in antibody genetics, as illustrated in the accompanying paper by Corcoran et al., can present a challenge to the development of population-wide protective vaccines. Fischer, Corcoran, et al. investigate influenza-specific antibodies to obtai…
Transcription factor RORγt is a central regulator of type 3 immunity, essential for host defense and tissue homeostasis. Fukui et al. identify a hierarchical CNS11-CNS9 enhancer cascade that governs RORγt expression across innate lymphocytes and antige…
