The cGAS-STING pathway detects intracellular DNA and activates a potent antiviral response. Dvorkin and colleagues summarize recent insights into cGAS-STING biology and its role in host defense, immunopathologies, and anti-tumor immunity.
RIG-I-like receptors (RLRs) are crucial for viral non-self RNA detection and triggering innate immune responses. Fujita et al. review the molecular basis of RNA recognition, regulatory mechanisms, viral antagonistic strategies, and pathologies caused b…
C-type lectin receptors (CLRs) comprise a vast family of proteins, several of which play key roles in the immune system. In this article, Reis e Sousa et al. review the biology of CLRs expressed by myeloid cells and their role in innate immune response…
Innate immunity relies on the NLR family of cytosolic pattern recognition receptors to detect pathogenic and sterile insults. In this issue of Immunity, Kanneganti and colleagues review the evolution and molecular characteristics of NLRs and discuss th…
TLRs play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns. Despite their protective roles, aberrations in TLRs contribute to inflammatory and autoimmune disorders. Akira et al. offer insights into TLR dis…
Stress hormones can contribute to cancer progression, but how immune cells play a role in this process is unclear. In a recent study in Cancer Cell, He et al. showed that glucocorticoids potentiate metastasis by skewing neutrophils toward pro-tumorigen…
Tissue-innervating neurons communicate with local immune and non-immune cells to balance homeostasis and inflammation. Deng, Gillis, Kaplan, and Chiu review some of the most well-defined and compelling pathways by which peripheral neurons regulate auto…
Recent studies revealed the existence of common principles of innate immune mechanisms across kingdoms and between the innate and adaptive branches of immunity in vertebrates. Lemaitre et al. discuss some key concepts of innate immunity that have renew…
Activation of the peripheral immune system contributes to stress-related neuropsychiatric symptoms. Recently in Nature, Cathomas et al. demonstrate that stress-induced social avoidance is mediated by monocyte-derived MMP8 that remodels the extracellula…
IL-23 activates pathogenic Th17 cells to drive inflammatory disease at barrier surfaces. Kim et al. now identify oral epithelial cells as the critical producers of IL-23 in human and mouse periodontitis, linking microbial dysbiosis to non-hematopoietic…
