To identify factors that can mediate post-ART HIV control, Ma et al. performed “omics” on PBMCs from PWH from 4 analytical treatment interruption cohorts. NK and T cell features were identified, and the top two genes in CD4+ T cells predicting delayed …
The genes that encode our antibodies display extensive variation between individuals. Corcoran et al. developed a high-throughput sequence-based method for identifying variations in antibody genes (ImmuneDiscover). This enabled the sequencing of 2,486 …
Sick animals often show reduced social engagement, a form of adaptive behavioral distancing thought to limit pathogen transmission beyond the infected individual. In a recent issue of Cell, Yang et al. identified a defined molecular and anatomical path…
The human antibody repertoire is broadly reactive with carbohydrate antigens represented in the host/self as well as the commensal microbiota. New et al. find that B cells reactive with the glycan constituent N-acetyl-glucosamine arise early in life an…
Vaccines targeting bacterial glycans can elicit inconsistent and/or poor protection in the young. Fryer, Pitt, et al. show that mucosal S. pyogenes infection triggers a glycan-specific B cell response that evolves with age and includes antibody class s…
Pre-existing antibodies restrict naive B cell entry into germinal centers, but how antibody feedback shapes ongoing reactions is unclear. In this issue of Immunity, Barbulescu et al. and Yan et al. show that antigen binding by locally produced high-aff…
Natural killer (NK) cells hold promise for cancer immunotherapy but show limited persistence in solid tumors. In this issue of Immunity, Ji et al. reveal that nutrient stress induces FLI1-mediated repression of pro-survival unfolded protein response pr…
Immune responses are energetically costly and must adapt to systemic nutrient availability. How immunity is reorganized to preserve host glucose during caloric restriction remains unclear. In this issue of Immunity, Menezes-Silva et al. show that dieta…
Microplastics are detectable in diverse human tissues, yet their biological impact remains unclear. In this issue of Immunity, Codo et al. dissect the mechanisms involved and find that polystyrene microplastics inhibit tissue-resident phagocyte clearan…
Intraocular pressure (IOP) is dysregulated in glaucoma, a leading cause of blindness. Immune contributions to IOP maintenance are poorly understood. Liu et al. reveal that long-lived resident tissue macrophages have a specialized role in IOP homeostasi…
