Specialized fibroblastic reticular cell (FRC) subsets in lymph nodes orchestrate the compartmentalization that guides immune cell migration, interaction, and function. Alouche et al. examine the signals governing FRC differentiation and identify a Notc…
MAIT cells acquire effector-memory and tissue-residency programs in the thymus. Paiva et al. demonstrate that MAIT cells can be selected by epithelial cells and egress the thymus at several developmental stages with subset-specific tissue tropisms and …
Loss of B cell tolerance, autoantibody production, and immune complex deposition are hallmarks of systemic lupus erythematosus. Al Souz et al. find that kidney-infiltrating CD8+ T cells differentiate from stem-like precursors in renal lymph nodes and c…
Intestinal microbiota can have both local and systemic effects on immunity and inflammation. Here, Yu et al. find that intestinal dysbiosis exacerbates atopic dermatitis pathology. Shifts in microbial abundances lead to elevated systemic levels of micr…
Using scRNA-seq of skin-innervating neurons, Voisin et al. show that skin-projecting nociceptor subpopulations differentially integrate the inflammatory response during allergic contact dermatitis. Although peptidergic TRPV1+ neurons control neutrophil…
Innate immune cell death is critical for host defense but drives inflammatory disease when dysregulated. In this issue of Immunity, Huang et al. report that the complement protein C1q activates macrophage mitochondrial SARM1 to deplete NAD+ and produce…
A lethal feature of glioblastoma is its ability to spread within the brain. In this issue of Immunity, Nebeling et al. use longitudinal three-photon imaging in an immunocompetent glioblastoma model to show that microglial responses at the far infiltrat…
RORγt is a key transcriptional regulator across diverse immune subsets. In this issue of Immunity, Fukui et al. show how Runx controls RORγt expression during early development and link progenitor specification to the diversification of RORγt+ innate i…
Immune experience can durably shape innate lymphocytes and their environments. Gasteiger and colleagues discuss how training, memory-like features, and dynamic niche interactions reprogram NK cells and ILCs to adapt their functions and tissue specializ…
In this review, Barreiro and colleagues synthesize molecular and cellular mechanisms of trained immunity across monocytes, tissue-resident macrophages, and HSPCs. They propose a unifying framework linking transcription factor activity, metabolic remode…
