No specific prophylaxis or treatment exists for West Nile virus (WNV) or related orthoflavivirus infections. Cervantes Rincón et al. characterize human antibody responses to WNV and identify protective epitopes on the virus envelope protein. A potent m…
Neutrophils have the capacity to both support and block tumor growth depending on their polarization state. Here, Pei et al. find that IFN-γ produced during immunotherapy induces PD-L1 expression by neutrophils with an aged phenotype that drives therap…
The mechanisms by which anti-RIPR antibodies inhibit parasite invasion are poorly understood. Williams et al. analyze monoclonal antibodies against the Plasmodium falciparum blood-stage protein RIPR and reveal that combinations of non-neutralizing anti…
How IL-23 drives an inflammatory Th17 cell state is poorly understood. Yang et al. identify two coordinated mechanisms specific to IL-23R signaling: the recruitment of CHD1 to stabilize RORγt expression and function and the blockade of glucocorticoid r…
Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glucocorticoid circuit and the underlying gene network …
Borden et al. examine primary, treatment-naive squamous cell carcinoma (SCC) tumors to determine the impact of immunoediting. Comparison of SCC tumors from immunocompetent and immunosuppressed patients demonstrates immune-mediated sculpting of the tumo…
Altered astrocyte-microglia interactions have been implicated in the pathogenesis of Alzheimer’s disease, but the underpinning mechanisms remain unclear. Zhang and colleagues show that astrocytic PAD2-mediated citrullination of vimentin activates micro…
The presence of tertiary lymphoid structures (TLSs) associates with improved anti-tumor immunity, and as such, understanding why some tumors develop TLSs is of prime interest. In the current issue of Cancer Cell, Kirschstein et al. demonstrate that TGF…
Cholesterol metabolism is an essential component of all immune cells. Xu and colleagues review the immunological functions of cholesterol metabolites and proteins and discuss how distinct cholesterol metabolic programs fulfil the metabolic and signalin…
Fibroblasts are highly attuned for immune crosstalk within lymphoid tissues. In this issue of Immunity, Alouche et al. provide insight into how fibroblast immunoregulatory phenotypes are acquired and maintained, revealing that Ccl19hi fibroblastic reti…
